Junyeop Daniel Roh
Associate Research ScientistCards
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Associate Research Scientist
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Neuroscience
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2026
Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids
Roh J, Bae M, Oh Y, Yang Y, Lee S, Hwang W, Yang E, Kim H, Jang H, Choi H, Kim H, Kim J, Kim E. Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids. Nature Communications 2026 PMID: 42215483, DOI: 10.1038/s41467-026-73881-9.Peer-Reviewed Original Research
2024
Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice
Roh J, Bae M, Kim H, Yang Y, Lee Y, Cho Y, Lee S, Li Y, Yang E, Jang H, Kim H, Kim H, Kang H, Ellegood J, Lerch J, Bae Y, Kim J, Kim E. Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice. Molecular Psychiatry 2024, 30: 2584-2596. PMID: 39633007, PMCID: PMC12092274, DOI: 10.1038/s41380-024-02865-2.Peer-Reviewed Original ResearchAutism spectrum disorderIntellectual disabilityLithium treatmentChronic lithium treatmentASD-related phenotypesCognitive deficitsBehavioral phenotypesSpectrum disorderASD-relatedBrain volumeSynaptic deficitsDYRK1A mutationsNeurodevelopmental disordersDendritic shrinkageHaploinsufficiency of DYRK1ASynaptic proteinsNewborn mutant miceMultiple signaling pathwaysDeficitsDisordersMutant miceDevelopmental delayPatient mutationsK miceSevere microcephalyAuthor Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae M, Roh J, Kim Y, Kim S, Han H, Yang E, Kang H, Lee S, Kim J, Kang R, Jung H, Yoo T, Kim H, Kim D, Oh H, Han S, Kim D, Han J, Bae Y, Kim H, Ahn S, Chan A, Lee D, Kim J, Kim E. Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Molecular Medicine 2024, 16: 2653-2653. PMID: 39242973, PMCID: PMC11473947, DOI: 10.1038/s44321-024-00125-y.Commentaries, Editorials and Letters
2022
Author Correction: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
Kim S, Lee S, Kim Y, Park J, Woo D, Kim D, Li Y, Shin W, Kang H, Yook C, Lee M, Kim K, Roh J, Ryu J, Jung H, Um S, Yang E, Kim H, Han J, Heo W, Kim E. Author Correction: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Nature Communications 2022, 13: 6544. PMID: 36319630, PMCID: PMC9626573, DOI: 10.1038/s41467-022-33972-9.Commentaries, Editorials and LettersEarly postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming
Kim H, Kim D, Cho Y, Kim K, Roh J, Kim Y, Yang E, Kim S, Ahn S, Kim H, Kang H, Bae Y, Kim E. Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming. Nature Communications 2022, 13: 5051. PMID: 36030255, PMCID: PMC9420115, DOI: 10.1038/s41467-022-32748-5.Peer-Reviewed Original ResearchConceptsBehavioral deficitsSelective serotonin reuptake inhibitorsExcitatory synaptic densitySerotonin reuptake inhibitorsAutistic-like behaviorsAutism spectrum disorderChronic treatmentSerotonergic receptorsChronic modulationPreventive effectSynaptic densityPostnatal symptomsSpectrum disorderSynaptic proteinsPersistent decreaseNeurodevelopmental disordersMiceDisordersDeficitsAdultsTranscriptomic changesFMRP targetsPreventsFluoxetineSymptomsSlc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes
Kim J, Roh J, Kim S, Kang H, Bae M, Kim E. Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. Frontiers In Molecular Neuroscience 2022, 15: 857820. PMID: 35321029, PMCID: PMC8936588, DOI: 10.3389/fnmol.2022.857820.Peer-Reviewed Original Research
2021
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
Kim S, Lee S, Kim Y, Park J, Woo D, Kim D, Li Y, Shin W, Kang H, Yook C, Lee M, Kim K, Roh J, Ryu J, Jung H, Um S, Yang E, Kim H, Han J, Heo W, Kim E. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Nature Communications 2021, 12: 2695. PMID: 33976205, PMCID: PMC8113471, DOI: 10.1038/s41467-021-22908-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCells, CulturedHEK293 CellsHumansImmunosuppressive AgentsLearning DisabilitiesMaze LearningMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Memory DisordersMice, Inbred C57BLMice, KnockoutNeuronal PlasticityNeuronsProteinsSignal TransductionSirolimusTOR Serine-Threonine KinasesConceptsHuman neural progenitor cellsNeural progenitor cellsActing antidepressantsInhibition balanceBehavioral deficitsHuman neuronsPsychiatric implicationsBrain disordersMouse brainMTORC1/2 inhibitorsNeuronsProgenitor cellsMTORNeural developmentNeurodevelopmentMiceTANC2MTORC1/2Embryonic lethalityMTORC2 complexRegulated inhibitionAdaptor/AntidepressantsKetamineHyperactivitySLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae M, Roh J, Kim Y, Kim S, Han H, Yang E, Kang H, Lee S, Kim J, Kang R, Jung H, Yoo T, Kim H, Kim D, Oh H, Han S, Kim D, Han J, Bae Y, Kim H, Ahn S, Chan A, Lee D, Kim J, Kim E. SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Molecular Medicine 2021, 13: emmm202012632. PMID: 33428810, PMCID: PMC7863395, DOI: 10.15252/emmm.202012632.Peer-Reviewed Original ResearchConceptsAmino acid transportersNMDAR functionGlycine levelsNMDAR currentsAcid transportersMutant PTEN proteinGlycine homeostasisNMDA receptorsBrain disordersBrain glycine levelsExtracellular glycine levelsNovel regulatorC-terminusPTEN proteinBrain glycineNMDAR hypofunctionInhibitory neurotransmitterÎ’-cateninProlineHuman neuronsNormal rangeExtracellular levelsGlycine transporterMouse brainProtein levels
2018
Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice
Jung H, Park H, Choi Y, Kang H, Lee E, Kweon H, Roh J, Ellegood J, Choi W, Kang J, Rhim I, Choi S, Bae M, Kim S, Lee J, Chung C, Yoo T, Park H, Kim Y, Ha S, Um S, Mo S, Kwon Y, Mah W, Bae Y, Kim H, Lerch J, Paik S, Kim E. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nature Neuroscience 2018, 21: 1218-1228. PMID: 30104731, DOI: 10.1038/s41593-018-0208-z.Peer-Reviewed Original ResearchConceptsDimorphic changesSynaptic transmissionNeuronal activityInhibitory synaptic transmissionMale mutant miceAutism spectrum disorderFemale miceNeuronal excitationNeuronal firingCHD8 mutationsMutant miceHeterozygous mutationsMiceDimorphic behaviorsUnderlying mechanismExtracellular vesiclesUltrasonic vocalizationsExpression of genesTranscriptomic profilesSpectrum disorderFemale counterpartsGene expressionASD risk genesExtracellular matrixExpressionNGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation
Um S, Ha S, Lee H, Kim J, Kim K, Shin W, Cho Y, Roh J, Kang J, Yoo T, Noh Y, Choi Y, Bae Y, Kim E. NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation. Cell Reports 2018, 23: 3839-3851. PMID: 29949768, DOI: 10.1016/j.celrep.2018.05.087.Peer-Reviewed Original Research
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