Junghee Jenny Shin, MD, PhD
she/her/hers
Assistant ProfessorCards
About
Research
Publications
2025
Immune dysregulation from a novel CTLA-4 haploinsufficiency variant
Brodsky N, Kennedy A, Glaser D, Jeffries L, Ji W, Natarajan E, Shin J, Sansom D, Lucas C, Lakhani S. Immune dysregulation from a novel CTLA-4 haploinsufficiency variant. Journal Of Human Immunity 2025, 2: e20250112. PMID: 41608053, PMCID: PMC12829747, DOI: 10.70962/jhi.20250112.Peer-Reviewed Original ResearchCTLA-4CTLA-4 haploinsufficiencyImmune dysregulationCTLA4 variantsCytotoxic T-lymphocyte antigen 4T-lymphocyte antigen-4CTLA-4 expressionHeterozygous loss-of-function variantsPatient T cellsImmune checkpoint receptorsT cell activationCTLA-4 functionLoss-of-function variantsHaploinsufficient variantsCheckpoint receptorsAntigen 4Autoimmune manifestationsRecurrent infectionsAutoimmune infiltrationT cellsImmune regulationAffected individualsHaploinsufficiencyLigand uptakeDysregulationCorrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Corrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578. EBioMedicine 2025, 123: 106095. PMID: 41447758, PMCID: PMC12799761, DOI: 10.1016/j.ebiom.2025.106095.Peer-Reviewed Original ResearchThe clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia
Yoo N, Kim S, Kim J, Ahn J, Kang I, Shin J. The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia. Frontiers In Immunology 2025, 16: 1549768. PMID: 40458401, PMCID: PMC12127307, DOI: 10.3389/fimmu.2025.1549768.Peer-Reviewed Original ResearchAssociation of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity
Novotny S, Yoo N, Chen J, Granoth M, Kohli-Pamnani A, Hsu F, Rodenas M, Steele R, Kaman K, Soffer G, Price C, Kuster J, Kang I, Osmani L, Shin J. Association of clinical manifestations and immune alterations with genetic variants of uncertain significance in patients concerned for inborn errors of immunity. Clinical Immunology 2025, 277: 110513. PMID: 40354868, DOI: 10.1016/j.clim.2025.110513.Peer-Reviewed Original ResearchInborn errors of immunityErrors of immunityGenetic variantsInborn errorsAssociation of clinical manifestationsGene clusterGene functionStudy evaluated associationsImmune alterationsDiagnostic challengeClinical manifestationsImmunological profileGenetic testingVUSGenesImmunological characteristicsImmune functionLaboratory dataImmunityVariantsAssociationPatientsDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokines
2024
The next frontier Defining and optimizing treatments for patients with type 2 low asthma
Zidan E, Wilson G, Shin J, Chupp G. The next frontier Defining and optimizing treatments for patients with type 2 low asthma. Annals Of Allergy Asthma & Immunology 2024, 134: 3-4. PMID: 39414022, DOI: 10.1016/j.anai.2024.10.013.Peer-Reviewed Original ResearchIL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4+ T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4+ T cell responsesT cell responsesPrimary antibody deficiencyCD4+ T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4+ T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4+ T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
McDonnell J, Cousins K, Younger M, Lane A, Abolhassani H, Abraham R, Al-Tamemi S, Aldave-Becerra J, Al-Faris E, Alfaro-Murillo A, AlKhater S, Alsaati N, Doss A, Anderson M, Angarola E, Ariue B, Arnold D, Assa’ad A, Aytekin C, Bank M, Bergerson J, Bleesing J, Boesing J, Bouso C, Brodszki N, Cabanillas D, Cady C, Callahan M, Caorsi R, Carbone J, Carrabba M, Castagnoli R, Catanzaro J, Chan S, Chandra S, Chapdelaine H, Chavoshzadeh Z, Chong H, Connors L, Consonni F, Correa-Jimenez O, Cunningham-Rundles C, D’Astous-Gauthier K, Delmonte O, Demirdag Y, Deshpande D, Diaz-Cabrera N, Dimitriades V, El-Owaidy R, ElGhazali G, Al-Hammadi S, Fabio G, Faure A, Feng J, Fernandez J, Fill L, Franco G, Frenck R, Fuleihan R, Giardino G, Galant-Swafford J, Gambineri E, Garabedian E, Geerlinks A, Goudouris E, Grecco O, Pan-Hammarström Q, Khani H, Hammarström L, Hartog N, Heimall J, Hernandez-Molina G, Horner C, Hostoffer R, Hristova N, Hsiao K, Ivankovich-Escoto G, Jaber F, Jalil M, Jamee M, Jean T, Jeong S, Jhaveri D, Jordan M, Joshi A, Kalkat A, Kanarek H, Kellner E, Khojah A, Khoury R, Kokron C, Kumar A, Lecerf K, Lehman H, Leiding J, Lesmana H, Lim X, Lopes J, López A, Tarquini L, Lundgren I, Magnusson J, Marinho A, Marseglia G, Martone G, Mechtler A, Mendonca L, Milner J, Mustillo P, Naderi A, Naviglio S, Nell J, Niebur H, Notarangelo L, Oleastro M, Ortega-López M, Patel N, Petrovic G, Pignata C, Porras O, Prince B, Puck J, Qamar N, Rabusin M, Raje N, Regairaz L, Risma K, Ristagno E, Routes J, Roxo-Junior P, Salemi N, Scalchunes C, Schuval S, Seneviratne S, Shankar A, Sherkat R, Shin J, Siddiqi A, Signa S, Sobh A, Lima F, Stenehjem K, Tam J, Tang M, Barros M, Verbsky J, Vergadi E, Voelker D, Volpi S, Wall L, Wang C, Williams K, Wu E, Wu S, Zhou J, Cook A, Sullivan K, Marsh R. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report. Journal Of Clinical Immunology 2024, 44: 86. PMID: 38578389, PMCID: PMC10997719, DOI: 10.1007/s10875-023-01613-5.Peer-Reviewed Original ResearchConceptsInborn errors of immunityCOVID-19 vaccineICU admissionInborn errors of immunity patientsInborn errorsUS Immunodeficiency NetworkErrors of immunityVaccination prior to infectionLogistic regression analysisVaccine safetyAntibody deficiencyRates of hospitalizationCOVID-19 severitySymptomatic anemiaOdds of hospitalizationCOVID-19 infectionRegistry databaseMRNA-basedCOVID-19 vaccine safetyPatientsOutpatient clinicEmergency room careICU careICUVaccine
2023
Modulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, You S, Racke M, Bucala R, Kang I. Modulating IL-1β and its receptors shapes spike-specific CD4+ T cell responses to mRNA vaccination. The Journal Of Immunology 2023, 210: 159.20-159.20. DOI: 10.4049/jimmunol.210.supp.159.20.Peer-Reviewed Original ResearchCOVID-19 mRNA vaccinesT cellsIL-1βIL-1R2MRNA vaccinesIL-1 receptor 1IL-1R1 expressionIL-1R2 expressionSpike-specific CD4Vaccine-induced CD4T cell immunityT cell responsesSpecific antibody productionMRNA vaccinationCell immunityDurable immunityIL-1R1IL-1BCD4Healthy individualsQuest DiagnosticsAntibody productionCell responsesReceptor 1Receptor system
2022
Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients
Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.Peer-Reviewed Original ResearchConceptsProstate cancer patientsCOVID-19 outcomesCancer patientsPoor COVID-19 outcomesAndrogen-androgen receptorExpression of TMPRSS2COVID-19 infectionSARS-CoV-2Directed therapyMean hospitalizationPCa patientsHospitalization ratesPCa casesRetrospective analysisOutcome differencesPatientsDefinitive conclusionsStatistical significanceData generate hypothesesHospitalizationTherapyTMPRSS2Cellular entryOutcomesARDT
Academic Achievements & Community Involvement
Clinical Care
Overview
Junghee Jenny Shin, MD, PhD, is a board-certified allergy and clinical immunology specialist who provides care for patients with a variety of allergic and immunologic conditions.
She focuses on diagnosing and managing immune deficiencies and immune dysregulation disorders, utilizing comprehensive immune profiling techniques to understand how these disorders develop and manifest.
Dr. Shin completed allergy and clinical immunology fellowship training (2017-2020) at Yale and joined the Section of Rheumatology, Allergy and Immunology in 2020. As an assistant professor of internal medicine and pediatrics at Yale School of Medicine, Dr. Shin studies how certain genetic factors influence the immune system and contribute to immune deficiencies and immune dysregulation disorders using advanced immune profiling.
Clinical Specialties
Internal Medicine; Allergy & Clinical Immunology
Fact Sheets
Penicillin Allergy
Learn More on Yale MedicineAllergic Contact Dermatitis
Learn More on Yale MedicineSeasonal Allergies (Allergic Rhinitis)
Learn More on Yale MedicineColds: How to Prevent Them
Learn More on Yale Medicine
Board Certifications
Allergy & Immunology
- Certification Organization
- AB of Allergy & Immunology
- Original Certification Date
- 2024
Yale Medicine News
News
News
- September 11, 2025
Finding Patterns in Genetic Uncertainty: Clues for Inborn Errors of Immunity
- June 07, 2024
Yale Pediatrics Announces New Section of Pediatric Immunology and Rheumatology and Interim Section Chief, Ian Ferguson, MD
- February 23, 2024
Department of Internal Medicine Promotions and Appointments (February 2024)
- June 13, 2023
Shin Awarded Immune Deficiency Foundation Grant
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Mailing Address
Allergy & Immunology
300 Cedar Street, TAC Building
New Haveng, CT 06520
United States
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