Jennefer Par-Young
Associate Research ScientistAbout
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Associate Research Scientist
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Yale Co-Authors
Frequent collaborators of Jennefer Par-Young's published research.
Publications Timeline
A big-picture view of Jennefer Par-Young's research output by year.
Richard Bucala, MD, PhD
Junghee Jenny Shin, MD, PhD
Insoo Kang, MD
Min Shin, PhD
Hong-Jai Park
Lais Osmani, MD, MHS
13Publications
110Citations
Publications
2026
Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis
Doherty E, Osmani L, Bilsborrow J, Par-Young J, Choi S, Tilstam P, Shin M, Piecychna M, Cai H, Leng L, Kim W, Kang I, Bucala R. Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2509156123. PMID: 41505516, PMCID: PMC12799170, DOI: 10.1073/pnas.2509156123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorT cell-dependent modelCollagen-induced arthritisT cellsImpact of gene deletionPathogenic roleMIF's roleCollagen-induced arthritis developmentEffector memory phenotypeRheumatoid arthritisMacrophage migration inhibitory factor inhibitionExperimental models of arthritisModel of collagen-induced arthritisT cell subpopulationsArthritogenic T cellsT cell activationExperimental modelHigh-expression alleleT lineage cellsAutoimmune inflammatory diseaseJoint synoviumMigration inhibitory factorModels of arthritisExpressed alleleMemory phenotype
2025
Corrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Corrigendum: “Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome” EBioMedicine, 2025, Feb:112:105578. EBioMedicine 2025, 123: 106095. PMID: 41447758, PMCID: PMC12799761, DOI: 10.1016/j.ebiom.2025.106095.Commentaries, Editorials and LettersInvestigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus
Lee S, Shin M, Lee Y, Osmani L, Seong W, Cai H, Par-Young J, Ahn J, Park H, Kim M, Unlu S, Kim H, Han M, Dong X, You S, Lee E, Kang I. Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus. EBioMedicine 2025, 119: 105898. PMID: 40857939, PMCID: PMC12398881, DOI: 10.1016/j.ebiom.2025.105898.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCD8+ T cellsCD8+ T cell subsetsT cell subsetsT cellsPeripheral bloodNeutrophil extracellular trapsEffector memoryGene signatureLupus pathogenesisImaging Mass CytometryEffector memory CD8+ T cellsCD8+ T cell accumulationCD8+ T cell infiltrationKidney tissueMemory CD8+ T cellsType I IFN gene signatureCD8+ T cellsEM CD8+ T cellsAnalysis of immune cellsCytotoxic molecule expressionT cell infiltrationT cell accumulationAssociated with treatment outcomeKidney tissues of patientsT cell heterogeneityDecreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome
Shin J, Shin H, Gutierrez A, Yoo N, Par-Young J, Osmani L, Shin M, Sanchez-Lara P, Bucala R, Soffer G, Kang I. Decreased T helper 1 cell function underlies recurrent sinopulmonary infections in the 17q12 deletion syndrome. EBioMedicine 2025, 112: 105578. PMID: 39891996, PMCID: PMC11840234, DOI: 10.1016/j.ebiom.2025.105578.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCD4+ T cellsRecurrent sinopulmonary infectionsT cell functionRNA-seq analysisT cellsHealthy controlsSinopulmonary infectionsRNA-seqT-betIFN-gFrequency of CD4+ T cellsCD4+ T cell functionTh1 transcription factor T-betDeletion syndromeFlow cytometryCompared to age-matched healthy controlsTranscription factor T-betDecreased T-betUrinary tract abnormalitiesAge-matched healthy controlsMultiplex assayDownstream effector cytokinesEffector cytokinesRecurrent infectionsTh17 cytokines
2024
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCD4+ T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4+ T cell responsesT cell responsesPrimary antibody deficiencyCD4+ T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4+ T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4+ T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal persons
2022
Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome
Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R. Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome. Clinical Rheumatology 2022, 42: 643-643. PMID: 36565380, PMCID: PMC9873696, DOI: 10.1007/s10067-022-06488-2.Commentaries, Editorials and LettersClinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome
Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R. Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome. Clinical Rheumatology 2022, 42: 443-451. PMID: 36401063, PMCID: PMC9873757, DOI: 10.1007/s10067-022-06448-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCentral nervous system involvementNervous system involvementPotential risk factorsPrimary Sjögren's syndrome patientsHigh-dose glucocorticoidsSjögren's syndrome patientsCNS involvementSystem involvementHigh-risk indicatorsImmunosuppressive therapyLung involvementSyndrome patientsC3 levelsRisk factorsPulmonary involvementPS patientsHigh-dose glucocorticoid administrationMultivariate logistic regression analysisAnti-SSA positivityHigh titer ANAAnti-SSA antibodiesLow C3 levelsPrimary Sjögren's syndromeComplement 4 levelsLogistic regression analysisEffect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients
Ünlü S, Shin J, Par-Young J, Simonov M, Vinetz J, Petrylak D, Kang I, Kim J. Effect of Androgen–Androgen Receptor Directed Therapy on COVID-19 Outcome in Prostate Cancer Patients. Cancer Investigation 2022, 41: 77-83. PMID: 36373994, DOI: 10.1080/07357907.2022.2139839.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProstate cancer patientsCOVID-19 outcomesCancer patientsPoor COVID-19 outcomesAndrogen-androgen receptorExpression of TMPRSS2COVID-19 infectionSARS-CoV-2Directed therapyMean hospitalizationPCa patientsHospitalization ratesPCa casesRetrospective analysisOutcome differencesPatientsDefinitive conclusionsStatistical significanceData generate hypothesesHospitalizationTherapyTMPRSS2Cellular entryOutcomesARDTMIF is a common genetic determinant of COVID-19 symptomatic infection and severity
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity. QJM 2022, 116: 205-212. PMID: 36222594, PMCID: PMC9620729, DOI: 10.1093/qjmed/hcac234.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMacrophage migration inhibitory factorLow-expression MIF alleleCOVID-19 infectionMIF allelesCATT7 alleleHealthy controlsCOVID-19Serum macrophage migration inhibitory factorSymptomatic SARS-CoV-2 infectionHigh-expression MIF allelesHigher serum MIF levelsRetrospective case-control studySARS-CoV-2 infectionFunctional polymorphismsAvailable clinical characteristicsMultinational retrospective studySerum MIF levelsUninfected healthy controlsSymptomatic COVID-19Tertiary medical centerHealthy control subjectsCase-control studyMigration inhibitory factorCoronavirus disease 2019Common functional polymorphisms
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