José Jaime Martínez-Magaña, BSc, MSc, PhD
Postdoctoral AssociateDownloadHi-Res Photo
About
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Titles
Postdoctoral Associate
Departments & Organizations
Education & Training
- PhD
- Universidad Juarez Autonoma de Tabasco, Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas - INMEGEN (2020)
- MSc
- Universidad Nacional Autonoma de Mexico, Laboratorio de Genomica de Enfermedades Psiquiatricas y Neurodegenerativas - INMEGEN (2017)
- BSc
- Universidad Nacional Autonoma de Mexico, Facultad de Estudios Superiores Zaragoza (2012)
Research
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Overview
Public Health Interests
Aging; Bioinformatics; Genetics, Genomics, Epigenetics; Mental Health; Network Analysis; Statistical Computing; Substance Use, Addiction
ORCID
0000-0003-0390-8252- View Lab Website
Montalvo-Ortiz Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of José Jaime Martínez-Magaña's published research.
Publications Timeline
A big-picture view of José Jaime Martínez-Magaña's research output by year.
Janitza Montalvo-Ortiz, PhD
Diana Núñez
Brenda Cabrera-Mendoza, MD, PhD
Joel Gelernter, MD
Hang Zhou, PhD
John Krystal, MD
67Publications
405Citations
Publications
Featured Publications
Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Pérez-Aldana B, Martínez-Magaña J, Mayén-Lobo Y, de Montellano D, Aviña-Cervantes C, Ortega-Vázquez A, Genis-Mendoza A, Sarmiento E, Soto-Reyes E, Juárez-Rojop I, Tovilla-Zarate C, González-Castro T, Nicolini H, López-López M, Monroy-Jaramillo N. Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers In Psychiatry 2022, 13: 870656. PMID: 35664466, PMCID: PMC9157596, DOI: 10.3389/fpsyt.2022.870656.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPathway genesDNA methylomeEpigenetic ageProtein-protein interactionsLong-term treatmentDifferential methylation sitesInfinium MethylationEPIC BeadChipMethylation sitesPsychopharmacological treatmentMethylationEPIC BeadChipContinuous clozapine treatmentDrug-naive patientsGenesMethylomeYears of treatmentLower mortality rateChronological ageCLZ treatmentClozapine treatmentMale patientsDelta agePsychiatric disordersPatientsPsychotic disordersMortality rateCentral and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence
Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence. Biomedicines 2022, 10: 1107. PMID: 35625844, PMCID: PMC9138536, DOI: 10.3390/biomedicines10051107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsPosttraumatic stress disorderPeripheral immune systemImmune systemInflammatory systemTrauma exposureStress disorderPeripheral immune dysregulationToll-like receptorsLifetime trauma exposurePotential novel drug targetsEtiology of PTSDImmune dysregulationInflammatory dysregulationHPA axisNovel drug targetsImmunological responseInflammatory signalingGeneral populationAnimal modelsIntegrative multi-omics approachPTSD treatmentMultifactorial disorderBrain tissueHallmark featureDysregulationGenome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphismThe Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico
Martínez-Magaña JJ, Genis-Mendoza AD, Velázquez J, Camarena B, del Campo Sanchez R, Bautista C, Gamiño M, Reséndiz E, Aguilar A, Medina-Mora ME, Nicolini H. The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico. Frontiers In Pharmacology 2020, 11: 324. PMID: 32390825, PMCID: PMC7188951, DOI: 10.3389/fphar.2020.00324.Peer-Reviewed Original ResearchCitationsAltmetricThe Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort
Medina-Mora M, Genis-Mendoza A, Villatoro Velázquez J, Bustos-Gamiño M, Bautista C, Camarena B, Martínez-Magaña J, Nicolini H. The Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort. International Journal Of Environmental Research And Public Health 2023, 20: 3109. PMID: 36833803, PMCID: PMC9961066, DOI: 10.3390/ijerph20043109.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMental healthPost-traumatic stressDrug use disordersMental health disordersSymptoms of maniaMental health symptomsRepresentative population sampleLittle recent informationIllegal drugsRisk factorsTobacco useUse disordersHealth disordersResponse rateHealth symptomsPrevalenceSymptomsInterviews of individualsComorbiditiesDrugsPopulation sampleNational surveySymptomatologyDisordersFinal sample
2025
Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Li H, Liu Y, Shi Y, Wang J, Nguyen T, Xie Y, Zheng W, Cheng Y, Cruz D, Modliszewski J, Terwilliger R, Sliby A, Martínez-Magaña J, Montalvo-Ortiz J, Roache J, Averill L, Young-McCaughan S, Shiroma P, Huber B, Lewis D, Glausier J, Holtzheimer P, Friedman M, Zhang J, Peterson A, Abdallah C, Valizadeh A, Zhang X, Xu K, Krystal J, Duman R, Zhao H, Corcoran D, Williamson D, Girgenti M. Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain. Biological Psychiatry 2025 PMID: 41192574, DOI: 10.1016/j.biopsych.2025.10.032.Peer-Reviewed Original ResearchAltmetricConceptsFear circuitryDNA methylationPost-traumatic stress disorderNeurobiology of PTSDTraumatic stress exposureDepressive disorder casesGene expressionSevere psychological traumaKetamine trialsPTSD patientsKetamine efficacyUnique biologyStress disorderDNA methylation signaturesCell typesMental disordersStress exposureSubcortical regionsPTSDPsychological traumaDisorder casesRNA-seqEpigenetic variationMethylation dataReference panelWhole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants
Wang L, Nuñez Y, Martínez-Magaña J, Rivera-Hernandez M, Mao Z, Brennand K, Montalvo-Ortiz J, Kranzler H, Gelernter J, Zhou H. Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants. Translational Psychiatry 2025, 15: 380. PMID: 41052974, PMCID: PMC12500996, DOI: 10.1038/s41398-025-03578-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWhole-exome sequencing studiesGenetic architectureRisk variantsGene-based collapsing testCross-ancestry meta-analysisContribution of rare coding variantsGenome-wide association studiesWhole-exome sequencing dataRare Coding VariantsLow-frequency variantsParticipants of European ancestryLoss-of-functionExome variantsCross-ancestrySequence dataOpioid dependenceAssociation studiesMissense variantsTop genesEuropean ancestrySuggestive associationsRare variantsAfrican ancestryFunctional studiesYale-PennDECODING RARE CNVS AND THEIR FUNCTIONAL INSIGHTS IN MAJOR DEPRESSIVE DISORDER FROM LATIN AMERICAN COHORTS
Nunez-Rios D, Nagamatsu S, Martínez-Magaña J, Nicolini H, Delia A, Lattig M, Marquez Y, Ferro E, Martinez K, Guisti P, group L, group P, Fernandez T, Montalvo-Ortiz J. DECODING RARE CNVS AND THEIR FUNCTIONAL INSIGHTS IN MAJOR DEPRESSIVE DISORDER FROM LATIN AMERICAN COHORTS. European Neuropsychopharmacology 2025, 99: 10. DOI: 10.1016/j.euroneuro.2025.08.472.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCopy-number variationsDosage-sensitive genesSingle nucleotide variantsMDD-associated genesDatabase of Genomic VariantsRare copy-number variationsCopy-number variation studyDiscovery of risk variantsComplex admixture patternsGenomes Project dataAdmixed Latin AmericansFunctional relevancePotential functional relevanceAncestry inferenceAdmixture patternsGenetic diversityGenomic variantsNucleotide variantsPopulation stratificationAssociation studiesGene regulationDNA sequencesCoding regionGenetic rearrangementsM11. MULTI-OMICS ANALYSIS OF ADVERSE CHILDHOOD EXPERIENCES (ACE) IN THE ORBITOFRONTAL CORTEX (OFC) OF HUMAN POSTMORTEM BRAIN
Nunez-Rios D, Jimenez L, Luppino J, Nagamatsu S, Martínez-Magaña J, Group T, Montalvo-Ortiz J. M11. MULTI-OMICS ANALYSIS OF ADVERSE CHILDHOOD EXPERIENCES (ACE) IN THE ORBITOFRONTAL CORTEX (OFC) OF HUMAN POSTMORTEM BRAIN. European Neuropsychopharmacology 2025, 99: 114. DOI: 10.1016/j.euroneuro.2025.08.207.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderSubstance use disordersComorbidity of post-traumatic stress disorderAdverse childhood experiencesAssociated with adverse childhood experiencesOrbitofrontal cortexUse disorderExposure to adverse childhood experiencesPostmortem brainsAdverse childhood experience exposureDevelopment of substance use disordersPostmortem brains of individualsAlcohol use disorderHuman postmortem brainBrains of individualsOFC neuronsOpioid use disorderEmotion regulationStress disorderBrain regionsMental disordersFluorescence-activated nuclei sortingPolysubstance useChildhood experiencesCell-type specificity
Academic Achievements & Community Involvement
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Honors
honor National Investigator Level I
10/29/2021International AwardNational Council of Science and TechnologyDetailsMexicohonor SHARP Professional Development scholarship
07/19/2021National AwardColumbia UniversityDetailsUnited Stateshonor Research Assistant Fellowship
06/01/2021International AwardNational Council of Science and TechnologyDetailsMexicohonor Honorific Mention in Doctoral Dissertation
01/15/2021International AwardJuarez Autonomous University of TabascoDetailsMexicohonor Exchange Scholarship
08/01/2019International AwardNational Council of Science and TechnologyDetailsMexico
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VA Connecticut Healthcare Errera Community Care Center - Orange Annex
Academic Office
200 Edison Road
Orange, CT 06477