Jose G Grajales-Reyes, MD, PhD
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Titles
Clinical Fellow
Departments & Organizations
Education & Training
- Regional Anesthesiology and Acute Pain Medicine Fellowship
- Yale - New Haven Hospital (2027)
- Non Degree Program
- Yale School Medicine, Anesthesiology Residency (2026)
- Anesthesiology Residency
- Yale - New Haven Hospital (2026)
- PhD
- Washington University School of Medicine, Neuroscience (2022)
- MD
- Washington University School of Medicine, Neuroscience (2022)
- BS
- University of Puerto Rico - Rio Piedras, Molecular and Cell Biology (2012)
Research
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Overview
Medical Research Interests
Neurobiology; Neurosciences; Pain
ORCID
0000-0002-3861-6842
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jose G Grajales-Reyes's published research.
Publications Timeline
A big-picture view of Jose G Grajales-Reyes's research output by year.
Research Interests
Research topics Jose G Grajales-Reyes is interested in exploring.
David Meseguer Garcia
Marc Schneeberger Pane, PhD
33Publications
2,029Citations
Publications
2026
Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked J, Page K, Barrows D, Carroll T, Grajales-Reyes J, Na D, Rodriguez-Diaz A, Furtado J, Isaza J, Schiffer H, Chen Y, Sun H, Kaushal N, Monenschein H, Barker D, Ortuño M, Renier N, Cohen P, Carlton M, Heintz N, Brice N, Friedman J, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nature Communications 2026, 17: 1295. PMID: 41530127, PMCID: PMC12868712, DOI: 10.1038/s41467-025-68056-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDorsal raphe nucleusRaphe nucleusChronic inhibitionMale miceInhibition of GABAergic neuronsSustained weight lossVentrolateral periaqueductal grayIn situ hybridizationHigh-fat dietGABAergic neuronsCounterregulatory mechanismsBrown adipose tissue thermogenesisAdipose tissue thermogenesisGenetic predispositionPeriaqueductal greyDiet-inducedMolecular profilingHigh-throughput drug screeningMetabolic phenotypeWeight managementInverse agonistsWeight lossHuman brainMiceBody weight
2025
Advances in energy balance & metabolism circuitry
Grajales-Reyes J. Advances in energy balance & metabolism circuitry. Advances In Genetics 2025, 113: 1-28. PMID: 40409794, DOI: 10.1016/bs.adgen.2025.02.003.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCentral nervous systemPeripheral organsMetabolic healthWeight managementMetabolic disordersNervous systemTherapeutic innovationsMetabolic circuitryNeuronal signalingBody weightEnergy expenditureNeural circuitsMetabolic homeostasisNeuromodulation techniquesCellular pathwaysPhysiological processesEnergy balanceMetabolismBrainstem
2024
Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?
Grajales-Reyes J, Chen B, Meseguer D, Schneeberger M. Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? Physiology 2024, 39: 218-230. PMID: 38536114, PMCID: PMC11368520, DOI: 10.1152/physiol.00034.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and Concepts
2023
Cell type-specific dissection of sensory pathways involved in descending modulation
Nguyen E, Grajales-Reyes J, Gereau R, Ross S. Cell type-specific dissection of sensory pathways involved in descending modulation. Trends In Neurosciences 2023, 46: 539-550. PMID: 37164868, PMCID: PMC10836406, DOI: 10.1016/j.tins.2023.04.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRostral ventromedial medullaDescending modulationPeriaqueductal greyResponse to noxious stimulationCell-type-specific manipulationsCell typesNeuronal firing patternsNociceptive behaviorRecordings of neuronal activityResponse to sensory inputVentromedial medullaNeuronal cell typesNoxious stimulationPharmacological manipulationSupraspinal structuresNeuronal activityFiring patternsSensory pathwaysOptogenetic approachIn vivo imagingMouse geneticsElectrical stimulationStimulationCellsTechnical advances
2022
Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors
Yang Y, Wu M, Vázquez-Guardado A, Wegener A, Grajales-Reyes J, Deng Y, Wang T, Avila R, Moreno J, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria A, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson Z, Gereau R, Good C, Xie Z, Huang Y, Kozorovitskiy Y, Rogers J. Author Correction: Wireless multilateral devices for optogenetic studies of individual and social behaviors. Nature Neuroscience 2022, 25: 1394-1394. PMID: 36071281, DOI: 10.1038/s41593-022-01175-6.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala
Samineni V, Grajales-Reyes J, Grajales-Reyes G, Tycksen E, Copits B, Pedersen C, Ankudey E, Sackey J, Sewell S, Bruchas M, Gereau R. Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala. ELife 2021, 10: e68130. PMID: 34032210, PMCID: PMC8172243, DOI: 10.7554/elife.68130.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCeA neuronsModulation of itchCentral amygdalaAnxiety-like behaviorVentral periaqueductal grayTranscriptional frameworkExpressed genesAversive experiencesRNA sequencingAppetitive behaviorSignaling pathwayPeriaqueductal greyNeural circuitsItch sensationViral tracing experimentsUnpleasant sensationsAmygdalaItchingNeuronsCEASurgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice
Grajales-Reyes J, Copits B, Lie F, Yu Y, Avila R, Vogt S, Huang Y, Banks A, Rogers J, Gereau R, Golden J. Surgical implantation of wireless, battery-free optoelectronic epidural implants for optogenetic manipulation of spinal cord circuits in mice. Nature Protocols 2021, 16: 3072-3088. PMID: 34031611, PMCID: PMC9273129, DOI: 10.1038/s41596-021-00532-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEpidural spaceMicroscale light-emitting diodesImplantable optoelectronic devicesOptoelectronic devicesBehavioral effectsOptogenetic manipulationSpinal circuitryIn vivo stimulationSpinal cord circuitrySpinal cord circuitsSurgical implantationOptical manipulationLight-emitting diodesSurgical approachStudy of brain circuitrySpinal afferentsSurgical implantation procedureImplantation procedureEpidural implantationNeuronal activityCircuitOptogenetic approachBrain circuitryNeural circuitryOptical parametersWireless multilateral devices for optogenetic studies of individual and social behaviors
Yang Y, Wu M, Vázquez-Guardado A, Wegener A, Grajales-Reyes J, Deng Y, Wang T, Avila R, Moreno J, Minkowicz S, Dumrongprechachan V, Lee J, Zhang S, Legaria A, Ma Y, Mehta S, Franklin D, Hartman L, Bai W, Han M, Zhao H, Lu W, Yu Y, Sheng X, Banks A, Yu X, Donaldson Z, Gereau R, Good C, Xie Z, Huang Y, Kozorovitskiy Y, Rogers J. Wireless multilateral devices for optogenetic studies of individual and social behaviors. Nature Neuroscience 2021, 24: 1035-1045. PMID: 33972800, PMCID: PMC8694284, DOI: 10.1038/s41593-021-00849-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHead-mountedWireless controlUser programmabilityFiber-optic approachWirelessNeuroscience applicationsNeuronal synchronyThermal propertiesProgrammable controllerMiniaturized devicesDesign considerationsPlatformControlled DeliveryAdvanced technologiesBiological tissuesIllumination profileEngineering studiesDevicesNarrowing optionsOptogenetic platformNeuroscience researchSocial interactionNeuroscienceDesignCapability
2020
A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea
Rengarajan S, Knoop K, Rengarajan A, Chai J, Grajales-Reyes J, Samineni V, Russler-Germain E, Ranganathan P, Fasano A, Sayuk G, Gereau R, Kau A, Knights D, Kashyap P, Ciorba M, Newberry R, Hsieh C. A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea. Cell Reports Medicine 2020, 1: 100124. PMID: 33196055, PMCID: PMC7659537, DOI: 10.1016/j.xcrm.2020.100124.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGut bacteriaInflammatory bowel diseaseIrritable bowel syndromeIBS-DIntestinal microbial communityDiarrhea-predominant irritable bowel syndromeFlares of inflammatory bowel diseaseIrritable Bowel Syndrome with DiarrheaInflammatory bowel disease patientsMicrobial communitiesCommensal bacteriaAntibacterial immunityMicrobial changesMicrobial alterationsFecal dysbiosisFecal bacteriaBacteriaSigns of diarrheaBarrier defectsRestraint stressSomatic symptom severityIgA responsesHealthy controlsBowel diseaseBowel syndrome
2019
Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray
Samineni V, Grajales-Reyes J, Sundaram S, Yoo J, Gereau R. Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray. Nature Communications 2019, 10: 4356. PMID: 31554789, PMCID: PMC6761157, DOI: 10.1038/s41467-019-12316-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeriaqueductal greyGlutamatergic neuronsGABAergic neuronsInhibition of glutamatergic neuronsChloroquine-evoked scratchingAversive componentChronic pruritisItch modulationCell type-specific modulationChronic itchItch processingChemogenetic manipulationItchingBidirectional modulationNeuronal populationsPeripheral basisNeuronsNeural circuitsNeuromodulatory hubAversive sensationsPeriaqueductPruritisMice
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honor Abraham L.Z. Mandel Award for Excellence in Resident Performance
06/13/2026Hospital System AwardYale Anesthesiology DepartmentDetailsUnited States
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