Marc Schneeberger Pane, PhD
Assistant Professor in Cellular and Molecular PhysiologyCards
Appointments
Contact Info
Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States
About
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Titles
Assistant Professor in Cellular and Molecular Physiology
Biography
Marc Schneeberger Pané received his B.S. in Pharmacy from Barcelona University, Catalonia in 2010. Next, he received his M.S. in Biomedicine from Barcelona University, Catalonia in 2011. He then studied how the powerhouse of the cell (mitochondria) is responsible for controlling whole body energy balance and metabolism in the canonical site for energy balance control (hypothalamus) with Marc Claret, PhD and earned his Ph.D. in Biomedicine at the Barcelona University, Catalonia in 2015. He then became a KAVLI postdoctoral fellow and a Pathway to Independence fellow in Prof. Jeffrey M.Friedman laboratory at The Rockefeller University. There he conducted whole mount activity maps in energy states to decipher the role of two novel subsets of neurons in the Dorsal Raphe Nucleus of the brainstem in energy balance control. He joined the Department of Cellular and Molecular Physiology at Yale University School of Medicine as an Assistant Professor in July 2022.
The Schneeberger Pané laboratory employs state-of-the-art technologies in neuroscience combining unbiased whole mount imaging of circuits, activity and vasculature; molecular profiling single-cell gene expression technologies, neuoromodulation (optogenetics, and chemogenetics) to understand the fundamental principles in the brain governing homeostasis. The overarching goal of the laboratory is to advance in the understanding of how neuronal, immune and vascular networks coordinately control homeostasis, with a focus on energy homeostasis.
Appointments
Cellular & Molecular Physiology
Assistant ProfessorPrimary
Other Departments & Organizations
- Cancer Signaling Networks
- Cellular & Molecular Physiology
- Interdepartmental Neuroscience Program
- Janeway Society
- Molecular Medicine, Pharmacology, and Physiology
- Neural Disorders
- Neuroscience Track
- Wu Tsai Institute
- Yale Cancer Center
- Yale Center for Molecular and Systems Metabolism (YMSM)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- NIH Pathway to Independence K99 Fellow
- The Rockefeller University (2022)
- Instructor
- Yale University (2022)
- KAVLI Postdoctoral Fellow
- The Rockefeller University (2019)
- JPB Postdoctoral Fellow
- The Rockefeller University (2017)
- PhD
- Barcelona University, Medicine (2015)
- MS
- Barcelona University, Biomedicine (2011)
- BS
- Barcelona University, Pharmacy (2010)
Research
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Overview
Medical Research Interests
ORCID
0000-0001-7369-104X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
David Meseguer Garcia
Tamas Horvath, DVM, PhD
María José Ortuño Romero, PhD
Jean-Leon Thomas, PhD
Jose G Grajales-Reyes, MD, PhD
Matthias Tschoep, MD
Nervous System Diseases
Publications
2026
Glycogen drives the sensory activation of POMC neurons
Gómez-Valadés A, Meseguer D, Varela L, Lienhard G, Fernández U, Vidal-Itriago A, Toledo M, Eyre E, Laudo B, Díaz-Castro F, Pozo M, Boutagouga Boudjadja M, Fos-Domènech J, García-Ramón P, Ferreira M, Altirriba J, Beiroa D, Chen B, Rodríguez-Díaz A, Milà-Guasch M, Chivite I, Obri A, Ramírez S, Haddad-Tóvolli R, Tahiri I, Gentry M, D’Agostino G, Nogueiras R, Renier N, Horvath T, Guinovart J, Duran J, Schneeberger M, Claret M. Glycogen drives the sensory activation of POMC neurons. Nature Metabolism 2026, 8: 1305-1329. PMID: 42204369, DOI: 10.1038/s42255-026-01535-7.Peer-Reviewed Original ResearchAltmetricA causal link between autoantibodies and neurological symptoms in long COVID
de Sá K, Silva J, Bayarri-Olmos R, Baker C, Lu Z, Gipson W, Na D, Chen B, Wenxue L, Khosroabadi D, Brinda R, Constable R, Omene B, Colom Díaz P, Kwon D, Rodrigues G, Heidecke H, Schulze-Forster K, Gross A, Shneer T, Clarke A, Linnekin T, Brate A, Brown L, Buda H, Jatiani S, Moise L, Greene K, Bhagchandani S, Bhattacharjee B, Gehlhausen J, Wood J, Tabacof L, Scheibenbogen C, Liu Y, Guan L, Schneeberger Pane M, Putrino D, Horvath T, Iwasaki A. A causal link between autoantibodies and neurological symptoms in long COVID. Cell 2026, 189: 3214-3235.e37. PMID: 42208499, DOI: 10.1016/j.cell.2026.04.042.Peer-Reviewed Original ResearchCitationsAltmetricObesity as a catalyst for neurodegeneration
Chen B, Rodríguez-Díaz A, Schneeberger M, Topol E. Obesity as a catalyst for neurodegeneration. Nature Metabolism 2026, 8: 546-558. PMID: 41760887, DOI: 10.1038/s42255-026-01477-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricIdentification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked J, Page K, Barrows D, Carroll T, Grajales-Reyes J, Na D, Rodriguez-Diaz A, Furtado J, Isaza J, Schiffer H, Chen Y, Sun H, Kaushal N, Monenschein H, Barker D, Ortuño M, Renier N, Cohen P, Carlton M, Heintz N, Brice N, Friedman J, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nature Communications 2026, 17: 1295. PMID: 41530127, PMCID: PMC12868712, DOI: 10.1038/s41467-025-68056-x.Peer-Reviewed Original ResearchCitationsNovel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice
Hunt J, Lund C, Chen B, Diaz A, Dmytriyeva O, Marcotorchino J, Löbner K, Mörl K, Andersen N, Ogueboule Z, Frank E, Stöhr J, Meseguer D, Panajotova V, Roux J, Clemmensen C, Sylow L, Schneeberger M, Beck‐Sickinger A, Pedersen S, Fosgerau K. Novel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice. Journal Of Cachexia Sarcopenia And Muscle 2026, 17: e70318. PMID: 42223236, PMCID: PMC13240157, DOI: 10.1002/jcsm.70318.Peer-Reviewed Original ResearchAltmetric
2025
Neurovascular plasticity as a modulator of hypothalamic function
Chen B, Furtado J, Schneeberger M. Neurovascular plasticity as a modulator of hypothalamic function. Reviews In Endocrine And Metabolic Disorders 2025, 27: 493-503. PMID: 40542999, DOI: 10.1007/s11154-025-09982-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchCitationsAltmetricGLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation
Na D, Schneeberger Pané M. GLP-1R agonists protect against Alzheimer’s disease by rewiring energy regulation. Nature Aging 2025, 5: 960-961. PMID: 40394226, DOI: 10.1038/s43587-025-00881-7.Peer-Reviewed Original ResearchCitationsAltmetricPrader Willi syndrome; advances in genetics
Hingar S, Schneeberger Pané M, Romero M. Prader Willi syndrome; advances in genetics. Advances In Genetics 2025, 113: 29-52. PMID: 40409799, DOI: 10.1016/bs.adgen.2025.03.001.ChaptersCitationsNeuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia
Ouro A, Rodríguez-Díaz A, López-González T, Romaus-Sanjurjo D, Estévez-Salguero Á, Iglesias-Rey R, Rodríguez-Arrizabalaga M, Fernández-Sanmartín P, Castro-Mosquera M, Debasa-Mouce M, Custodia A, Aramburu-Núñez M, Muñoz-González M, Aguiar P, González-García I, Schneeberger M, Nogueiras R, Diéguez C, Castillo J, Sobrino T, López M. Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia. Metabolism 2025, 167: 156160. PMID: 39961478, PMCID: PMC12005051, DOI: 10.1016/j.metabol.2025.156160.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity Swiss National Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Israel Science Foundation
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Spanish National Evaluation and Foresight Agency
2019 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity ANR:AAP French National Agency
2020 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity Argentinian Ministry of Science and Technology
2020 - PresentPeer Review Groups and Grant Study SectionsReviewer
Honors
honor Heidi Diabetes Award
09/24/2025International AwardHelmholtz ZenteumDetailsGermanyhonor Alzheimer Disease Research Center Scholar
05/01/2024Yale School of Medicine AwardNeurology DepartmentDetailsUnited Stateshonor Diabetes Research Center Scholar
05/01/2024Yale School of Medicine AwardEndocrinology DepartmentDetailsUnited Stateshonor Matilda Ziegler Foundation Scholar
01/01/2024National AwardMatilda E. Ziegler FoundationDetailsUnited Stateshonor Yale SenNet Scholar
01/01/2024Yale School of Medicine AwardYale Aging CenterDetailsUnited States
Teaching & Mentoring
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Mentoring
Amanda Rodriguez Diaz
Graduate student2023 - Present
Willing and Available to Mentor
- Students
- Residents
- Clinical Fellows
- Postdoctoral Researchers
News & Links
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Media
News
- June 30, 2026
Women’s Health Research at Yale and SWHR’s Symposium Highlights the Power of Collaboration to Advance Women’s Health Research
- June 02, 2026
New Discovery Explains How the Brain Prepares the Body for Food
- May 28, 2026Source: Yale News
Yale Study Links Some Long COVID Patients to Autoimmune Responses
Get In Touch
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Contacts
Cellular & Molecular Physiology
333 Cedar Street, B-Wing, E Level
New Haven, Connecticut 06510
United States
Events
Yale Only Ken Huaijin Loh, PhD, BSc - Tamas Horvath, DVM, PhD - Juan Uribe Isaza - Maryann Platt - Jane Rebecca Taylor, PhD - Marc Claret - Marcela Carmona - Nicolas Renier - Priya Rajasaetupathy - Sho Aoki - Paul Muller - Anoj IlangesZoom link available for those who cannot attend in person.