David Meseguer Garcia
he/him/his
Graduate StudentAbout
Research
Publications
2026
Glycogen drives the sensory activation of POMC neurons
Gómez-Valadés A, Meseguer D, Varela L, Lienhard G, Fernández U, Vidal-Itriago A, Toledo M, Eyre E, Laudo B, Díaz-Castro F, Pozo M, Boutagouga Boudjadja M, Fos-Domènech J, García-Ramón P, Ferreira M, Altirriba J, Beiroa D, Chen B, Rodríguez-Díaz A, Milà-Guasch M, Chivite I, Obri A, Ramírez S, Haddad-Tóvolli R, Tahiri I, Gentry M, D’Agostino G, Nogueiras R, Renier N, Horvath T, Guinovart J, Duran J, Schneeberger M, Claret M. Glycogen drives the sensory activation of POMC neurons. Nature Metabolism 2026, 8: 1305-1329. PMID: 42204369, DOI: 10.1038/s42255-026-01535-7.Peer-Reviewed Original ResearchIdentification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked J, Page K, Barrows D, Carroll T, Grajales-Reyes J, Na D, Rodriguez-Diaz A, Furtado J, Isaza J, Schiffer H, Chen Y, Sun H, Kaushal N, Monenschein H, Barker D, Ortuño M, Renier N, Cohen P, Carlton M, Heintz N, Brice N, Friedman J, Schneeberger M. Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice. Nature Communications 2026, 17: 1295. PMID: 41530127, PMCID: PMC12868712, DOI: 10.1038/s41467-025-68056-x.Peer-Reviewed Original ResearchNovel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice
Hunt J, Lund C, Chen B, Diaz A, Dmytriyeva O, Marcotorchino J, Löbner K, Mörl K, Andersen N, Ogueboule Z, Frank E, Stöhr J, Meseguer D, Panajotova V, Roux J, Clemmensen C, Sylow L, Schneeberger M, Beck‐Sickinger A, Pedersen S, Fosgerau K. Novel Long‐Acting Ghrelin Analogue PEP‐064 Restores Energy Balance in C26 and Lewis Lung Carcinoma–Induced cachexia in Mice. Journal Of Cachexia Sarcopenia And Muscle 2026, 17: e70318. PMID: 42223236, PMCID: PMC13240157, DOI: 10.1002/jcsm.70318.Peer-Reviewed Original Research
2024
Rewiring of the glymphatic landscape in metabolic disorders
Chen B, Meseguer D, Lenck S, Thomas J, Schneeberger M. Rewiring of the glymphatic landscape in metabolic disorders. Trends In Endocrinology And Metabolism 2024, 36: 710-720. PMID: 39638721, PMCID: PMC12134147, DOI: 10.1016/j.tem.2024.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice
Qi Q, Zhang H, Jin Z, Wang C, Xia M, Chen B, Lv B, Peres Diaz L, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L, Schneeberger M, Yu X. Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. Nature Metabolism 2024, 6: 1601-1615. PMID: 39030389, DOI: 10.1038/s42255-024-01068-x.Peer-Reviewed Original ResearchBurning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?
Grajales-Reyes J, Chen B, Meseguer D, Schneeberger M. Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation? Physiology 2024, 39: 218-230. PMID: 38536114, PMCID: PMC11368520, DOI: 10.1152/physiol.00034.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain.
Cuitavi J, Andrés-Herrera P, Meseguer D, Campos-Jurado Y, Lorente JD, Caruana H, Hipólito L. Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain. Glia 2023, 71: 1906-1920. PMID: 37017183, DOI: 10.1002/glia.24374.Peer-Reviewed Original ResearchDynamic rewiring of neurovasculature in health and disease
Chen B, Meseguer D, Renier N, Schneeberger M. Dynamic rewiring of neurovasculature in health and disease. Trends In Molecular Medicine 2023, 29: 786-788. PMID: 37487781, PMCID: PMC10528198, DOI: 10.1016/j.molmed.2023.06.011.Peer-Reviewed Original Research
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