Jorge Sepulcre, MD, PhD
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentSpatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueicheku E, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3783.Peer-Reviewed Original ResearchTau accumulationCognitive changesPositron emission tomographyEarly cognitive changesLongitudinal positron emission tomographyAmyloid-betaCortical patternsAlzheimer's diseaseTauAging BrainCognitive scoresPreclinical ADOlder adultsSpatiotemporal levelsEmission tomographyBrainComplex roleAccumulationImaging markersAmyloidDifferential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks
Qureshi A, Nielsen J, Sepulcre J. Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks. Cerebral Cortex 2025, 35: bhae474. PMID: 40007052, PMCID: PMC11859958, DOI: 10.1093/cercor/bhae474.Peer-Reviewed Original ResearchConceptsInferior parietal lobuleSuperior temporal gyrusLarge-scale networksDeletion carriersHeteromodal association areasDifferential linksHypo-connectivitySocial impairmentTemporal gyrusParietal lobulePosterior insulaAssociated with greater communicationAberrant connectivityAssociation areasCingulate sulcusBehavioral changesGlobal coherenceEntangled connectionsSulcusGreater communicationInsulaCingulateGyrusCopy number variationsImpairmentMapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
Saiz-Masvidal C, De la Peña-Arteaga V, Bertolín S, Diez I, Juaneda-Seguí A, Martínez-Zalacaín I, Chavarría-Elizondo P, Subirà M, Menchón J, Sepulcre J, Fullana M, Soriano-Mas C. Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain. Brain Structure And Function 2025, 230: 137. PMID: 40828212, PMCID: PMC12364969, DOI: 10.1007/s00429-025-02996-4.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusVentral tegmental areaSubstantia nigra pars compactaFunctional connectivityMonoaminergic systemsRs-FCLocus coeruleusMedial frontal cortexResting-state functional MRIDorsal raphe nucleus projectsRs-fMRI analysisPrefrontal cortexTegmental areaFrontal cortexNeurotransmitter systemsRaphe nucleusDopaminergic pathwaysNeuropsychiatric conditionsInsular cortexNeurotransmitter networksBehavioral flexibilityMonoaminergic nucleiSubcortical regionsFunctional MRIBrain activity
2024
Stepwise pathways from the olfactory cortex to central hub regions in the human brain
Menelaou G, Diez I, Zelano C, Zhou G, Persson J, Sepulcre J, Olofsson J. Stepwise pathways from the olfactory cortex to central hub regions in the human brain. Human Brain Mapping 2024, 45: e26760. PMID: 39688149, PMCID: PMC11651219, DOI: 10.1002/hbm.26760.Peer-Reviewed Original ResearchConceptsDefault-mode networkCortical hubsHuman brainDefault-mode network regionsAnterior olfactory nucleusFunctional connectivity researchProcessing rewardOrbitofrontal cortexAnterior insulaOlfactory tubercleFrontal sulcusPiriform cortexOlfactory cortexCortical subregionsOlfactory nucleusAssociation cortexLanguage acquisitionParietal operculumNeural activityTemporal regionsCortical networksSynchronous neural activityOlfactory pathwaySensory cortexOlfactory systemDecoding cortical chronotopy—Comparing the influence of different cortical organizational schemes
Mecklenbrauck F, Sepulcre J, Fehring J, Schubotz R. Decoding cortical chronotopy—Comparing the influence of different cortical organizational schemes. NeuroImage 2024, 303: 120914. PMID: 39491762, DOI: 10.1016/j.neuroimage.2024.120914.Peer-Reviewed Original ResearchConceptsRich-clubInter-subject correlationStructural rich clubNetwork module structureLevels of cognitive controlInter-subject correlation analysisGraph-theoretic measures of centralityResting-state fMRIHigher cortical areasOrganizational schemeMode of processingIntrinsic timescalesBayesian model comparisonCognitive controlTask fMRIDiffusion-weighted imaging dataCortical regionsModulated structureTimescalesCortical areasNetwork hubsDigital sequencesCytoarchitectural differencesMeasures of centralityModel comparisonReorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsMultimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption
d’Oleire Uquillas F, Sefik E, Li B, Trotter M, Steele K, Seidlitz J, Gesue R, Latif M, Fasulo T, Zhang V, Kislin M, Verpeut J, Cohen J, Sepulcre J, Wang S, Gomez J. Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption. Molecular Psychiatry 2024, 30: 1558-1572. PMID: 39390225, DOI: 10.1038/s41380-024-02769-1.Peer-Reviewed Original ResearchAutism spectrum disorderNeurotypical childrenFunctional connectivityMultimodal evidenceFunctional connectivity analysisModel of autismCerebro-cerebellar pathwayAtypical connectivitySpectrum disorderConnectivity analysisEarly adolescenceASD childrenCerebellar influenceBehavioral developmentNeurodevelopmental disordersFunctional-structural relationshipsCerebellar structuresAutismYoung childhoodLiving brainCerebellumFunctional synchronizationThalamusSignificant lateralizationCerebral cortexChanges in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first‐episode psychosis
He R, Alonso‐Sánchez M, Sepulcre J, Palaniyappan L, Hinzen W. Changes in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first‐episode psychosis. Human Brain Mapping 2024, 45: e70030. PMID: 39301700, PMCID: PMC11413563, DOI: 10.1002/hbm.70030.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisSpontaneous speechCortical hierarchyHierarchical brain organizationHigher-order association corticesPicture descriptionMode networkBrain organizationAssociation cortexPsychosisCognitive functionMental dysfunctionPrimary sensorimotorSpeech patternsSyntactic associationsCortical organizationSemantic networkSensorimotorSituational languageSpeechLanguageHierarchical organizationHierarchical distanceNeurocognitionFMRICortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brain