Marc David Normandin, PhD
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240.
Xia Y, Dhaynaut M, Chemli Y, Lois C, Hanseeuw B, Thibault E, Groot C, Ossenkoppele R, Johnson K, El Fakhri G, Normandin M, Guehl N. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240. Journal Of Nuclear Medicine 2025, jnumed.125.270165. PMID: 40533354, DOI: 10.2967/jnumed.125.270165.Peer-Reviewed Original Research3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy
Jee K, Bijari F, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kang J, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G. 3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy. Radiotherapy And Oncology 2025, 206: s3543-s3544. DOI: 10.1016/s0167-8140(25)01927-9.Peer-Reviewed Original Research273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation
Dan R, Borchers L, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, Fakhri G, Normandin M, Pizzagalli D. 273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation. Biological Psychiatry 2025, 97: s208. DOI: 10.1016/j.biopsych.2025.02.511.Peer-Reviewed Original ResearchPO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY
Kang J, Bijari F, Jee K, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Fakhri G, Levine R, Lehmann H. PO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY. Heart Rhythm 2025, 22: s484. DOI: 10.1016/j.hrthm.2025.03.1230.Peer-Reviewed Original ResearchPET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction. IEEE Transactions On Biomedical Engineering 2025, 72: 1057-1066. PMID: 39446540, PMCID: PMC11875991, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugsSelective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils
Lee S, Pearson T, Dhaynaut M, MacDonagh A, Wey H, Wilks M, Roth B, Hooker J, Normandin M. Selective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils. Journal Of Medicinal Chemistry 2025, 68: 1632-1644. PMID: 39772615, DOI: 10.1021/acs.jmedchem.4c02287.Peer-Reviewed Original ResearchConceptsMu-opioid receptorsPositron emission tomographyIn vivo PET scansCarbon-11Neurobiological studiesCopper-mediated radiofluorinationMu-opioidReceptor imagingPET scansBrain uptakeFavorable pharmacokineticsImaging evaluationHigh molar activityMass doseEmission tomographyHalf-life of fluorine-18Synthetic opioidsFluorine-18Half-lifeIn vitro binding assaysBinding assaysClinical research useMolar activityCarfentanilResearch use
2024
Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner
Chemli Y, Marin T, Orehar M, Dolenec R, Normandin M, Gascón D, Gola A, Grogg K, Pavón G, Razdevsek G, Pestotnik R, Fakhri G. Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10656225.Peer-Reviewed Original ResearchGaussian mixture modelGaussian process regressionPoint spread functionAccurate image reconstructionMaximum likelihood estimation maximizationShift-variant convolutionsImage reconstructionMixture modelProcess regressionEstimation maximizationTime-of-flight (TOFPanel architectureSpread functionArchitectureParameter interpolationHigh resolution time-of-flight (TOFTOF-PET scannerBrain phantomFitting processPositron emission tomography scannerSimulated point sourcesConvolutionAlgorithmEffective diagnosisSize benefitsDeciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics
Hong J, Bae S, Cavinato L, Seifert R, Ryhiner M, Rominger A, Erlandsson K, Wilks M, Normandin M, El-Fakhri G, Choi H, Shi K. Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics. Theranostics 2024, 14: 7122-7139. PMID: 39629134, PMCID: PMC11610134, DOI: 10.7150/thno.99516.Peer-Reviewed Original ResearchFree‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W, Han P, Marin T, Mounime I, Eslahi S, Djebra Y, Chi D, Bijari F, Normandin M, Fakhri G, Ma C. Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Magnetic Resonance In Medicine 2024, 93: 536-549. PMID: 39402014, PMCID: PMC11606777, DOI: 10.1002/mrm.30284.Peer-Reviewed Original ResearchExtracellular volume mappingContrast agent injectionExtracellular volumeGradient echo readoutECV mapsAgent injectionWhole heartEcho readoutExtracellular volume valuesVoxel-by-voxelInversion recovery sequenceSpatial resolutionScan timeImaging timeIn vivo studiesHealthy volunteersModel-based methodsRecovery sequenceInjectionReadoutNovel multi-modal methodology to investigate placebo response in major depressive disorder
Cusin C, Dillon D, Belleau E, Normandin M, Petibon Y, El-Fakri G, Dhaynaut M, Hooker J, Kaptchuk T, McKee M, Hayden E, Meyer A, Jahan A, Origlio J, Ang Y, Brunner D, Kang M, Long Y, Fava M, Pizzagalli D. Novel multi-modal methodology to investigate placebo response in major depressive disorder. Journal Of Affective Disorders 2024, 368: 1-7. PMID: 39233242, DOI: 10.1016/j.jad.2024.08.226.Peer-Reviewed Original ResearchPlacebo responseDepressive disorderRates of placebo responseMesocorticolimbic dopaminergic pathwayExpectation of rewardAntidepressant responseMesolimbic systemReward circuitryNeurobiological underpinningsNeurobiological mechanismsDopaminergic activityDopaminergic systemPlacebo respondersSymptom reductionDopaminergic pathwaysMulti-modal methodologyPlacebo phenomenonPsychological constructsTreatment developmentMDDPlacebo-controlledClinical trialsDouble-blindRewardDesigning clinical trials
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