Caroline Muiler Barbosa Nogueira

I hold a PhD in Biological Sciences from the Federal University of Rio de Janeiro (2023), a leading institution in Brazil and Latin America. My research focused on the therapeutic potential of extracellular vesicles from mesenchymal stromal cells in sepsis-induced acute kidney injury. I also have a Master’s degree in Biophysics (2017) and a Bachelor’s degree in Biology (2014) from the same university.

My postdoctoral research at the Ameen Lab, Yale School of Medicine, focuses on how acute stress affects kinase signaling and CFTR function in SGK1 knockout mice. Previously, I worked as a postgraduate research visitor at St. Michael’s Hospital, University of Toronto, where I studied the role of TMi-018 in modulating macrophage activation during a cytokine storm.

I have played a key role in numerous collaborative projects at the Federal University of Rio de Janeiro, contributing to studies on the therapeutic effects of nitazoxanide in COVID-19 pneumonia and the benefits of mitochondria isolated from mesenchymal stromal cells in experimental sepsis. At Yale University, I have contributed to research on the effects of Dex alone and Dex+Trikafta on CFTR localization in hdF508 mouse jejunum, as well as on CFTR High Expresser (CHE) Best4+ cells, exploring new implications for intestinal physiology, diarrheal disease, and cystic fibrosis. My extensive research experience spans various domains, including developing animal models of renal, respiratory, and intestinal diseases, molecular biology, and cell culture techniques.

My contributions to the scientific community are evident in my publications and presentations at international conferences, showcasing my commitment to advancing our understanding of complex biological processes and potential therapeutic interventions.