Andrew J. Hudak
About
Research
Publications
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Bhagchandani SH, Ehrenzeller S, Pires IS, Chaudhary N, Booth CJ, Kwon DI, Koutsioumpa C, Baker CA, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper WB, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Sci Immunol 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.
2025
Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens
Bachtel N, Cullen J, Liu M, Erickson S, Kutyavin V, El-Naccache D, Florsheim E, Lim J, Sullivan Z, Imaeda R, Hudak A, Zhang C, Medzhitov R. Intestinal mast cell–derived leukotrienes mediate the anaphylactic response to ingested antigens. Science 2025, 389: eadp0246-eadp0246. PMID: 40773543, PMCID: PMC12513082, DOI: 10.1126/science.adp0246.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsIntestinal mast cellsMast cellsIntravenous injectionAntigen-induced responsesFood allergen exposureLeukotriene synthesisCysteinyl leukotriene synthesisOral anaphylaxisTissue mast cellsMucosal exposureConnective tissue mast cellsIntestine of miceEffector functionsAnaphylactic responseReceptor 1Allergen exposureArachidonate 5-lipoxygenaseAnaphylaxisMiceLeukotrieneHeterogeneous populationCellsInjectionAntagonist
2023
Remodeling of colon plasma cell repertoire within ulcerative colitis patients
Scheid J, Eraslan B, Hudak A, Brown E, Sergio D, Delorey T, Phillips D, Lefkovith A, Jess A, Duck L, Elson C, Vlamakis H, Plichta D, Deguine J, Ananthakrishnan A, Graham D, Regev A, Xavier R. Remodeling of colon plasma cell repertoire within ulcerative colitis patients. Journal Of Experimental Medicine 2023, 220: e20220538. PMID: 36752797, PMCID: PMC9949229, DOI: 10.1084/jem.20220538.Peer-Reviewed Original ResearchConceptsUnfolded protein responsePlasma cellsUlcerative colitisPlasma cell repertoireB cell clonesRNA-seqUlcerative colitis patientsAntigen presentation genesProtein responseColonic mucosal cellsTranscriptomic changesBacterial strainsCell repertoireGut plasma cellsB cellsInflammatory infiltrateClonal expansionColitis patientsIgA antibodiesUC pathogenesisBacterial antigensPresentation genesHealthy individualsMucosal cellsClones