Charalampia Koutsioumpa, MD, PhD
Hospital ResidentCards
About
Research
Publications
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Bhagchandani SH, Ehrenzeller S, Pires IS, Chaudhary N, Booth CJ, Kwon DI, Koutsioumpa C, Baker CA, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper WB, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Sci Immunol 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.Medication Usage in Motor Neuron Disease and Spinal Muscular Atrophy: Insights from the Muscular Dystrophy Association Neuromuscular Observational Research Data Hub
Joo D, Koutsioumpa C, McLaren N, Habib A, Roy B. Medication Usage in Motor Neuron Disease and Spinal Muscular Atrophy: Insights from the Muscular Dystrophy Association Neuromuscular Observational Research Data Hub. Journal Of Clinical Neuromuscular Disease 2026, 27: 175-176. PMID: 42226228, DOI: 10.1097/cnd.0000000000000566.Peer-Reviewed Original Research
2023
Dural arteriovenous fistula of the craniocervical junction
Koutsioumpa C, Ho D, Siegel C, Patel N, Smirnakis S, Babikian V. Dural arteriovenous fistula of the craniocervical junction. Practical Neurology 2023, 24: 148-151. PMID: 37949659, DOI: 10.1136/pn-2023-003912.Peer-Reviewed Original ResearchConceptsdural AV fistulasAV fistulacraniocervical junctionMR scansdural arteriovenous fistulaprogressive myelopathyretrosigmoid craniotomyarterial feedersarteriovenous fistulacervical spineradiographic evolutiondiagnostic angiogrammeningohypophyseal arteryspinal imagingfistulawork-uplesion characteristicsnon-revealingangiographyangiogrammeningohypophysealmyelopathycraniotomyarterylesionsSkin-type-dependent development of murine mechanosensory neurons
Koutsioumpa C, Santiago C, Jacobs K, Lehnert B, Barrera V, Hutchinson J, Schmelyun D, Lehoczky J, Paul D, Ginty D. Skin-type-dependent development of murine mechanosensory neurons. Developmental Cell 2023, 58: 2032-2047.e6. PMID: 37607547, PMCID: PMC10615785, DOI: 10.1016/j.devcel.2023.07.020.Peer-Reviewed Original ResearchConceptsmechanosensory neuronstype I bone morphogenetic proteinlanceolate endingsglabrous skinmouse mutantslongitudinal lanceolate endingsmorphogenetic proteinsMeissner corpusclesmolecular profilingend organsskin maturationskin typetarget tissuespost-natallyskin targetinghair folliclesneuronsearly developmenthairy skinskinmutants
2021
Mechanoreceptor synapses in the brainstem shape the central representation of touch
Lehnert B, Santiago C, Huey E, Emanuel A, Renauld S, Africawala N, Alkislar I, Zheng Y, Bai L, Koutsioumpa C, Hong J, Magee A, Harvey C, Ginty D. Mechanoreceptor synapses in the brainstem shape the central representation of touch. Cell 2021, 184: 5608-5621.e18. PMID: 34637701, PMCID: PMC8556359, DOI: 10.1016/j.cell.2021.09.023.Peer-Reviewed Original ResearchConceptsMechanoreceptor synapseshighest density of mechanoreceptorsskin regionsrepresentation of touchsense gentle touchglabrous skindevelopmental refinementdensity of mechanoreceptorscentral representationtouchpostnatal developmentrepresentationsynaptic connectionscentral synapsesbrainstemperipheral mechanoreceptorsskin sensationgentle touchsynapsesskincortical mapsmechanoreceptors
2020
Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies
Markozannes G, Koutsioumpa C, Cividini S, Monori G, Tsilidis K, Kretsavos N, Theodoratou E, Gill D, Ioannidis J, Tzoulaki I. Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies. European Journal Of Epidemiology 2020, 36: 11-36. PMID: 32978716, PMCID: PMC7847446, DOI: 10.1007/s10654-020-00681-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsmeta-analyses of observational studiesumbrella reviewmeta-analysessystematic reviewMendelian randomizationhealth outcomesobservational studyumbrella review of systematic reviewsreview of systematic reviewsCochrane Database of Systematic ReviewsCochrane DatabaseDatabase of Systematic ReviewsMendelian randomization studieshealth-related outcomeschronic health outcomesstudy meta-analysessmall-study effectsevidence of associationvalidity of associationsreview of evidenceglobal assessmentMR analysisMR studiesexcess significanceC-reactive protein
2019
A scalable platform for the development of cell-type-specific viral drivers
Hrvatin S, Tzeng C, Nagy M, Stroud H, Koutsioumpa C, Wilcox O, Assad E, Green J, Harvey C, Griffith E, Greenberg M. A scalable platform for the development of cell-type-specific viral drivers. ELife 2019, 8: e48089. PMID: 31545165, PMCID: PMC6776442, DOI: 10.7554/elife.48089.Peer-Reviewed Original ResearchConceptscell type-specificcell type specificity of gene expressioncell type-specific enhancersgene expressionperturbation of gene functionspecificity of gene expressionheterologous gene expressionDNA regulatory elementscell type-specific mannerfunction of enhancerscell typesmammalian cell typesregulatory elementsviral reagentsgene functiongenetic accessibilityindividual enhancersmammalian cerebral cortexexpressioncellscortical interneuronscerebral cortexATAC
2017
Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy
Simon C, Dai Y, Van Alstyne M, Koutsioumpa C, Pagiazitis J, Chalif J, Wang X, Rabinowitz J, Henderson C, Pellizzoni L, Mentis G. Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy. Cell Reports 2017, 21: 3767-3780. PMID: 29281826, PMCID: PMC5747328, DOI: 10.1016/j.celrep.2017.12.003.Peer-Reviewed Original ResearchConceptsresistant motor neuronsamino-terminal phosphorylationpost-translational modificationscell-autonomous activityspinal muscular atrophypost-translational modifications of p53nuclear accumulationmotor neuronsinduction of p53 signalinggenetic inhibitionmodification of p53phosphorylation of p53activation of p53inhibition of p53accumulation of p53nuclear accumulation of p53genetic inhibition of p53muscular atrophyselective deathserine 18spinal motor neuronsmotor neuron deathmotor neuron degenerationp53 signalinglate disease stages
2015
Interleukin-6 and risk of colorectal cancer: results from the CLUE II cohort and a meta-analysis of prospective studies
Kakourou A, Koutsioumpa C, Lopez D, Hoffman-Bolton J, Bradwin G, Rifai N, Helzlsouer K, Platz E, Tsilidis K. Interleukin-6 and risk of colorectal cancer: results from the CLUE II cohort and a meta-analysis of prospective studies. Cancer Causes & Control 2015, 26: 1449-1460. PMID: 26220152, PMCID: PMC4763881, DOI: 10.1007/s10552-015-0641-1.Peer-Reviewed Original ResearchConceptsCLUE II cohortrisk of colorectal cancermeta-analysis of prospective studiesrectal cancer riskcancer riskmeta-analysisrisk of colon cancerconditional logistic regression modelsconfidence intervalscolorectal cancercolon cancer riskNested Case-Control Studysmall-study effectsmatched odds ratiosprospective studylogistic regression modelscase-control studystatistically significant riskcolon cancerinverse associationcancer casesodds ratioPurposeThe associationmodifiable variablesmultivariable adjustment