Kaelyn Sumigray, PhD
Assistant Professor of GeneticsDownloadHi-Res Photo
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Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
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Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Contact Info
Appointments
Genetics
Primary
Additional Titles
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
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About
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Assistant Professor of Genetics
Co-Director, Yale Summer Enrichment Research Experience, Yale Center for Clinical Investigation (YCCI)
Biography
Kaelyn Sumigray earned her B.S. from Union College in 2006. She obtained her Ph.D. in 2011 from the Department of Cell Biology at Duke University. She was a postdoctoral fellow first at the University of North Carolina at Chapel Hill, from 2012-2013, where she was awarded an NIH Kirschstein postdoctoral fellowship, followed by a postdoctoral fellow at Duke University with Terry Lechler from 2013-2019, where she was awarded a Dermatology Foundation Research Grant. She joined the Yale faculty in 2019.
Last Updated on April 19, 2025.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral associate
- Duke University (2019)
- Postdoctoral Fellow
- University of North Carolina at Chapel Hill (2013)
- PhD
- Duke University, Cell Biology (2011)
- BS
- Union College, Biology (2006)
Research
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Overview
Medical Research Interests
Actin Cytoskeleton; Cell Adhesion; Cell Polarity; Cell Shape; Cytoskeleton; Intestinal Polyps; Intestine, Small; Morphogenesis; Organogenesis; Stem Cell Niche; Stem Cells
ORCID
0000-0002-1267-7559- View Lab Website
Sumigray lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Kaelyn Sumigray's published research.
Publications Timeline
A big-picture view of Kaelyn Sumigray's research output by year.
Research Interests
Research topics Kaelyn Sumigray is interested in exploring.
Nadia Ameen, MBBS
Zachary Smith, PhD
Bluma Lesch, MD, PhD
Maria Figetakis
Timothy Nottoli, PhD
Andrea Barbieri, MD
42Publications
1,305Citations
Cell Adhesion
Stem Cells
Intestine, Small
Morphogenesis
Cell Polarity
Cell Shape
Publications
2026
HIV-1-encoded circular RNA enhances viral transcription through Tat binding
Obi P, Yan L, Dujsikova A, Yeh Y, Li I, Mueller N, Back H, Yi B, Liu N, Mbadugha F, Yu H, Brown C, St. Denis K, Landry M, Sumigray K, Emu B, Ho Y, Chen Y. HIV-1-encoded circular RNA enhances viral transcription through Tat binding. Nature Microbiology 2026, 1-14. PMID: 41826685, DOI: 10.1038/s41564-026-02271-0.Peer-Reviewed Original ResearchAltmetricPFKM governs metabolic shifts throughout skeletal muscle differentiation
Campos M, Nguyen S, Kong X, Yang Y, Watson R, Gromova A, Livelo C, Franco C, Cabral J, Seabrook L, Dai S, Liu Y, Zhou M, Hanse E, Sumigray K, La Spada A, Seldin M, Plikus M, Nicholas D, McNulty R, Kong M, Yokomori K, Albrecht L. PFKM governs metabolic shifts throughout skeletal muscle differentiation. Nature Metabolism 2026, 8: 489-505. PMID: 41735679, PMCID: PMC12945692, DOI: 10.1038/s42255-026-01457-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPhosphofructokinase 1Glycolytic intermediate 3-phosphoglycerateLysosomal degradationCell fate decisionsProtein arginine methyltransferasesPentose phosphate pathwayDegron motifArginine methyltransferasesPhosphate pathwayFate decisionsCell identitySkeletal muscle differentiationSkeletal muscle lineageCompartmentalized metabolismExpression of PFKMGlycolytic enzymesMetabolic shiftPFKMWnt signalingMuscle lineageMuscle differentiationSpatiotemporal dynamicsMetabolismGlycolysisDifferentiationFertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage
Rainsford S, Tse K, Walters B, Oh J, Sumigray K, Lesch B, Smith Z. Fertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage. Biology Of Reproduction 2026, ioag010. PMID: 41556312, DOI: 10.1093/biolre/ioag010.Peer-Reviewed Original ResearchConceptsWild type spermIntracytoplasmic sperm injectionProtamine 2Early stages of embryogenesisStages of embryogenesisEpididymal maturationKO spermEpididymal spermPaternal genomeInduction of DNA damageProtamine-2Sperm motilityFunctional zygotePaternal genetic materialMaternal meiosisPRM2SpermSperm DNAOocyte's abilityBlastocyst stageSperm injectionPreimplantation developmentSpermatozoan DNAGenetic materialPronucleus development
2025
Shaping the intestine: The role of cell morphology and spatial dynamics in development
Wang Y, Wen Z, Sumigray K. Shaping the intestine: The role of cell morphology and spatial dynamics in development. Current Topics In Developmental Biology 2025, 166: 67-99. PMID: 41856742, DOI: 10.1016/bs.ctdb.2025.10.002.Peer-Reviewed Original ResearchConceptsCell fate specificationCell shape changesExtracellular matrix interactionsActomyosin dynamicsCrypt-villus axisCytoskeletal reorganizationFate specificationLate embryogenesisVillus morphogenesisSpatiotemporal regulationEpithelial-mesenchymal signalingIntestinal morphogenesisMatrix interactionsTube elongationMicrobial threatsCell morphologyNutrient absorptionIn vitro organoid systemsFunctional specializationMorphogenesisEpithelial cellsEmbryogenesisEpithelial turnoverAbsorptive surface areaSpatial dynamicsNkx2-3 defines the splenic vascular patterning in a lineage-and-dose-dependent manner 9187
Balogh P, Balogh P, Váradi K, Berta G, Heidt D, Figetakis M, Sumigray K, Kellermayer Z. Nkx2-3 defines the splenic vascular patterning in a lineage-and-dose-dependent manner 9187. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2624.Peer-Reviewed Original ResearchConceptsLineage-restricted expressionLYVE-1Vascular patternMarginal sinusImpaired humoral immune responseRed pulpGene dosageSplenic vasculatureLymphatic capillariesVE-cadherin-CreMarginal reticular cellsHumoral immune responsePeripheral maintenanceExpression of Nkx2KO miceEctopic inductionLymphocyte differentiationSplenic structureEndothelial venulesImmune responseMAdCAM-1Lymphatic vesselsNKX2Lymphatic circulationMiceEpidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions
He H, Boraas L, Bell J, Gong X, Iannaccone S, Wen Z, Mak M, Carlson M, Sumigray K, Nicoli S. Epidermal stem cells control periderm injury repair via matrix-driven specialization of intercellular junctions. Nature Communications 2025, 16: 8967. PMID: 41073376, PMCID: PMC12514158, DOI: 10.1038/s41467-025-64040-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuperficial epidermal cellsAdherens junctionsEpidermal stem cellsIntegrin-mediated adhesionExtracellular matrixRegulating adhesion moleculesRegions of collagenLaminin deficiencyIn vivoFin foldEpidermal cellsGenetic reductionDesmosome formationStem cellsWound healing capacitySpecialized junctionsCell contactJunctional specializationsIntercellular junctionsSkin-healing propertiesDesmosomesAdhesion moleculesHuman keratinocyte modelCellsLamininCFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease
Dos Reis D, Jin J, Santos A, Dastoor P, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen N. CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and cystic fibrosis disease. American Journal Of Physiology - Cell Physiology 2025, 329: c1411-c1428. PMID: 41005986, DOI: 10.1152/ajpcell.00082.2025.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsMeSH KeywordsAnimalsCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDuodenumEnterocytesGene Knockout TechniquesGuanylate Cyclase-Activating ProteinsHumansHydrogen-Ion ConcentrationIon ChannelsJejunumMaleMyosin Type INatriuretic PeptidesNeuronsOrganoidsRatsRats, Sprague-DawleyReceptors, EnterotoxinSingle-Cell Gene Expression AnalysisConceptsCHE cellsNeuropod cellsGuanylyl cyclase-CApical domainHigh-expressing cellsProximal small intestineRat jejunumScRNA-seq studiesHuman intestineSingle-cell RNA sequencingCystic fibrosisCF rat modelsSmall intestineSubpopulation of epithelial cellsLuminal pH regulationAcid-sensing receptorsWild-type animalsCystic fibrosis diseaseRNA sequencingProtein immunolocalizationIntestinal physiologyRostrocaudal axisRelevant mRNAsWild-typeRat modelPROTAMINE 2 DEFICIENT SPERM CAUSE ABNORMAL EMBRYOGENESIS IN MICE
Rainsford S, Sumigray K, Smith Z, Lesch B. PROTAMINE 2 DEFICIENT SPERM CAUSE ABNORMAL EMBRYOGENESIS IN MICE. Fertility And Sterility 2025, 124: e10. DOI: 10.1016/j.fertnstert.2025.05.012.Peer-Reviewed Original ResearchEvidence of secondary Notch signaling within the rat small intestine.
Zagoren E, Dias N, Santos A, Smith Z, Ameen N, Sumigray K. Evidence of secondary Notch signaling within the rat small intestine. Development 2025, 152 PMID: 40371707, PMCID: PMC12188240, DOI: 10.1242/dev.204277.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSecretory lineageRegulate luminal pHSecretory cellsNotch signalingSecretory cell typesSmall intestinal epithelial cellsRNA sequencing dataIntestinal epithelial cellsIntestinal stem cellsSmall intestineFate in vivoFibrosis pathophysiologyRat small intestineCrypt progenitorsTranscription factorsEpithelial cellsRat jejunumStem cellsPseudotime trajectory analysisRare populationLuminal pHRatsHigher expressionIntestinal functionIn vitroCFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease
dos Reis D, Jin J, Santos A, Nogueira C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, Mc Carron A, Smith Z, Sumigray K, Ameen N. CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease. Physiology 2025, 40: 1127. DOI: 10.1152/physiol.2025.40.s1.1127.Peer-Reviewed Original ResearchConceptsCHE cellsGuanylyl cyclase-CNeuropod cellsApical domainRat jejunumHuman intestineSingle-cell RNA sequencingCystic fibrosisLuminal pH regulationSubpopulation of epithelial cellsLong basal processesScRNA-seqRNA sequencingAcid-sensing receptorsWild-type animalsCystic fibrosis diseaseIncreased abundanceHigh-expressing cellsProtein immunolocalizationIntestinal physiologyMorphological coreWild-typeBasal processesHCO3- secretionCFTR
Academic Achievements & Community Involvement
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Activities
activity American Heart Association
2022 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity eLife
2022 - PresentJournal ServiceRevieweractivity Science
2023 - PresentJournal ServiceRevieweractivity Nature Cell Biology
2021 - PresentJournal ServiceRevieweractivity Journal of Clinical Investigation
2022 - PresentJournal ServiceReviewer
Honors
honor Chen Innovation Award
03/01/2022Yale School of Medicine AwardYale Stem Cell CenterDetailsUnited Stateshonor Basic Research Award
03/03/2014National AwardDermatology Foundation
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SHM I 336
Academic Office
Sterling Hall of Medicine, I-Wing
333 Cedar Street
New Haven, CT 06510
389 NSB
Lab
Nathan Smith Building
315 Cedar Street
New Haven, CT 06510
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May 202621Thursday
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