Stephanie Thorn, MSc, PhD
Assistant Professor of Medicine (Cardiovascular Medicine)DownloadHi-Res Photo
Cards
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
About
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Titles
Assistant Professor of Medicine (Cardiovascular Medicine)
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Biography
Dr Stephanie L. Thorn, MSc, PhD is an Assistant Professor in the Section of Cardiovascular Medicine, Department of Internal Medicine. Dr Thorn received her PhD at the University of Ottawa Heart Institute in Cellular and Molecular Medicine. She is currently the Associate Director of the Yale Translational Research Imaging Center (YTRIC). Her research interests are centered on cardiovascular imaging, using PET, SPECT and CT to develop new approaches in the interrogation of molecular pathways, quantification of blood flow and alterations in myocardial function. Dr Thorn specifically pursues translational research in ischemia-reperfusion remodeling, myocardial infarction and right ventricular heart failure.
Last Updated on February 11, 2025.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryComparative Medicine
Research ScientistSecondary
Other Departments & Organizations
Education & Training
- PhD
- University of Ottawa, Cellular and Molecular Medicine (2013)
- MSc
- University of Guelph, Human Biology and Nutritional Sciences (2003)
- BSc (Hon)
- University of Guelph, Human Kinetics (2001)
Research
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Overview
Medical Research Interests
Computed Tomography Angiography; Diseases; Heart Failure; Heart Failure, Diastolic; Hypertrophy, Right Ventricular; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Single Photon Emission Computed Tomography Computed Tomography
ORCID
0000-0003-0020-0814- View Lab Website
YTRIC
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie Thorn's published research.
Publications Timeline
A big-picture view of Stephanie Thorn's research output by year.
Research Interests
Research topics Stephanie Thorn is interested in exploring.
Albert Sinusas, MD
Chi Liu, PhD
James Duncan, PhD
Edward J Miller, MD, PhD
Yi-Hwa Liu, PhD
Alaa Alashi, MD, MHS
88Publications
1,669Citations
Myocardial Infarction
Single Photon Emission Computed Tomography Computed Tomography
Radionuclide Imaging
Positron Emission Tomography Computed Tomography
Heart Failure
Myocardial Reperfusion Injury
Publications
2025
Corrigendum to “Applying dual energy computed tomography to postmortem coronary computed tomographic angiography” [J Cardiovasc Comput Tomogr (in press)]
Solomon N, Hoerner M, Vermillion B, Jang S, Sanchez H, Gosangi B, Staib L, Thorn S, Liu C, Sinusas A. Corrigendum to “Applying dual energy computed tomography to postmortem coronary computed tomographic angiography” [J Cardiovasc Comput Tomogr (in press)]. Journal Of Cardiovascular Computed Tomography 2025 PMID: 41309332, DOI: 10.1016/j.jcct.2025.11.003.Peer-Reviewed Original ResearchApplying dual energy computed tomography to postmortem coronary computed tomographic angiography
Solomon N, Hoerner M, Vermillion B, Jang S, Sanchez H, Gosangi B, Staib L, Thorn S, Liu C, Sinusas A. Applying dual energy computed tomography to postmortem coronary computed tomographic angiography. Journal Of Cardiovascular Computed Tomography 2025 PMID: 41176442, PMCID: PMC12712555, DOI: 10.1016/j.jcct.2025.10.016.Peer-Reviewed Original ResearchConceptsDual-energy CTCoronary computed tomographic angiographyTomographic angiographyDual-energy computed tomographySimultaneous characterizationCoronary artery patencyContrast agentsIodinated contrastGadolinium contrastArtery patencyComputed tomographyMyocardial perfusionEpicardial vesselsPostmortem computed tomographyTissue perfusionGadolinium agentsVascular patencyVessel obstructionMyocardial tissuePostmortem settingAngiographyIntramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction
Melvinsdottir I, Midgett D, Lee S, Thorn S, Uman S, Avendaño R, Lysyy T, Zohora F, Chen K, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction. Circulation Cardiovascular Imaging 2025, 18: e018357. PMID: 41017463, DOI: 10.1161/circimaging.125.018357.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLeft ventricular remodelingVentricular remodelingPost-MIEjection fractionMyocardial infarctionHydrogel deliveryIntramyocardial deliveryIntramyocardial injectionMyocardial segmentsLeft ventricular ejection fractionRemote myocardial segmentsVentricular ejection fractionEnd-diastolic volumeFactor VIII expressionCine computed tomographyDays post-MIControl saline injectionsIntramyocardial injection of hydrogelGamma well countingAlpha v beta 3Scar burdenBalloon occlusionRegional inflammationSaline injectionMyocardial angiogenesisComparative Study of Bone-Avid SPECT Tracers: In Search of a Diagnostic Target of Cardiac Amyloidosis
Zohora F, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Liu C, Miller E, Thorn S, Sinusas A. Comparative Study of Bone-Avid SPECT Tracers: In Search of a Diagnostic Target of Cardiac Amyloidosis. Journal Of Nuclear Cardiology 2025, 50: 102377. DOI: 10.1016/j.nuclcard.2025.102377.Peer-Reviewed Original ResearchA generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging
Xie H, Gan W, Ji W, Chen X, Alashi A, Thorn S, Zhou B, Liu Q, Xia M, Guo X, Liu Y, An H, Kamilov U, Wang G, Sinusas A, Liu C. A generalizable diffusion framework for 3D low-dose and few-view cardiac SPECT imaging. Medical Image Analysis 2025, 106: 103729. PMID: 40752375, PMCID: PMC12360895, DOI: 10.1016/j.media.2025.103729.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsImage qualityNetwork re-trainingDeep learning methodsCardiac SPECT imagingLow-doseSPECT imagesContextual informationDiffusion frameworkLearning methodsConsistency strategyRe-trainingAcquisition settingsLow count levelsFine-tuningSpatial informationVariation constraintCardiac catheterization resultsImage dataMyocardial perfusion imagingCoronary artery diseaseProjection dataCatheterization resultsImage volumesScanner geometryProjective measurementsMultidetector CT And Fluoroscopy Guided Epicardial Delivery Of Therapuetic Hydrogels To Myocardium Early Post Myocardial Infarction Results In Improved Global Function
Sinusas A, Jang S, Vermillion B, Ahn S, Burns R, Zohora F, Guerrera N, Rickmann A, Maduka C, Duncan J, Burdick J, Thorn S. Multidetector CT And Fluoroscopy Guided Epicardial Delivery Of Therapuetic Hydrogels To Myocardium Early Post Myocardial Infarction Results In Improved Global Function. Journal Of Cardiovascular Computed Tomography 2025, 19: s75. DOI: 10.1016/j.jcct.2025.05.177.Peer-Reviewed Original ResearchEarly detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies?
Cho S, Jang S, Heerdt P, Thorn S, Sinusas A. Early detection of lung injury and matrix metalloproteinase activation in ARDS could improve diagnostic and therapeutic strategies? Expert Review Of Respiratory Medicine 2025, 19: 899-901. PMID: 40462542, PMCID: PMC12354204, DOI: 10.1080/17476348.2025.2515993.Peer-Reviewed Original ResearchUsing Foundation Models as Pseudo-label Generators for Pre-clinical 4D Cardiac CT Segmentation
Rickmann A, Thorn S, Ahn S, Lee S, Uman S, Lysyy T, Burns R, Guerrera N, Spinale F, Burdick J, Sinusas A, Duncan J. Using Foundation Models as Pseudo-label Generators for Pre-clinical 4D Cardiac CT Segmentation. Lecture Notes In Computer Science 2025, 15673: 253-265. DOI: 10.1007/978-3-031-94562-5_23.Peer-Reviewed Original ResearchConceptsImage segmentationRobust Medical Image SegmentationAccurate pseudo labelsPseudo-label generationSelf-training strategySelf-training approachMedical image segmentationEnhance segmentation accuracyCardiac image segmentationImprove segmentation qualitySelf-training processPseudo-labelsDomain shiftConsecutive framesCardiac image analysisDeep learningSegmentation qualitySegmentation accuracyModeling tasksIterative updateTemporal inconsistencyMotion trackingCT segmentationHuman datasetsImage analysisRIGHT AND LEFT VENTRICULAR MYOCARDIAL BLOOD FLOW PREDICTS INCIDENT HEART FAILURE AND DEATH IN PERSONS WITH SLEEP DISTURBED BREATHING
Aneni E, Emokpae M, Kapadia S, deKemp R, Beanlands R, Klein R, Yaggi H, Miller E, Veledar E, Thorn S, Sinusas A. RIGHT AND LEFT VENTRICULAR MYOCARDIAL BLOOD FLOW PREDICTS INCIDENT HEART FAILURE AND DEATH IN PERSONS WITH SLEEP DISTURBED BREATHING. Journal Of The American College Of Cardiology 2025, 85: 1479. DOI: 10.1016/s0735-1097(25)01963-1.Peer-Reviewed Original ResearchIncreasing angular sampling for dedicated cardiac single photon emission computed tomography scanner: Implementation with deep learning and validation with human data
Xie H, Alashi A, Thorn S, Chen X, Zhou B, Sinusas A, Liu C. Increasing angular sampling for dedicated cardiac single photon emission computed tomography scanner: Implementation with deep learning and validation with human data. Journal Of Nuclear Cardiology 2025, 49: 102168. PMID: 39986346, PMCID: PMC12227299, DOI: 10.1016/j.nuclcard.2025.102168.Peer-Reviewed Original ResearchCitations
Academic Achievements & Community Involvement
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Activities
activity Hotspot Imaging in Cardiovascular Disease: Methodology of Image Acquisition and Tracer Quantification
06/27/2023 - 06/27/2023Oral PresentationSociety of Nuclear Medicine and Molecular Imaging Annual MeetingDetailsChicago, IL, United States
News & Links
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- Contrast CT images of a normal myocardium and one with right ventricle heart failure.
- Using non-invasive SPECT/CT hybrid imaging, the reduced perfusion area can be quantified. At 3-days post-ischemia, the same area shows an increase in the radiotracer uptake of the matrix metalloproteinase agent, Tc-99m RP805. This tracer is an index of cardiac remodeling.
News
- November 12, 2025
Inaugural Cardiovascular Medicine Translational Research Award Announces First Recipients
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- March 18, 2024
Meet Yale Internal Medicine: Stephanie Thorn, MSc, PhD
- January 16, 2024
Yale's Cardiac Imaging Center Revolutionizes Translational Research
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Academic Office Number
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Mailing Address
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States