Stephanie Thorn, MSc, PhD
Assistant Professor of Medicine (Cardiovascular Medicine)DownloadHi-Res Photo
Cards
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
Appointments
Cardiovascular Medicine
Primary
Comparative Medicine
Secondary
Additional Titles
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Contact Info
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States
About
Titles
Assistant Professor of Medicine (Cardiovascular Medicine)
Associate Director, Yale Translational Research Imaging Center (Y-TRIC)
Biography
Dr Stephanie L. Thorn, MSc, PhD is a Assistant Professor in the Section of Cardiovascular Medicine, Department of Internal Medicine. Dr Thorn received her PhD at the University of Ottawa Heart Institute in Cellular and Molecular Medicine. She is currently the Associate Director of the Yale Translational Research Imaging Center (YTRIC). Her research interests are centered on cardiovascular imaging, using PET, SPECT and CT to develop new approaches in the interrogation of molecular pathways, quantification of blood flow and alterations myocardial function. Dr Thorn specifically pursues translational research in ischemia-reperfusion remodeling, myocardial infarction and right ventricular heart failure.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryComparative Medicine
Research ScientistSecondary
Other Departments & Organizations
- Cardiovascular Medicine
- Comparative Medicine
- Internal Medicine
- Yale Translational Research Imaging Center (Y-TRIC)
Education & Training
- PhD
- University of Ottawa, Cellular and Molecular Medicine (2013)
- MSc
- University of Guelph, Human Biology and Nutritional Sciences (2003)
- BSc (Hon)
- University of Guelph, Human Kinetics (2001)
Research
Overview
Medical Research Interests
Computed Tomography Angiography; Diseases; Heart Failure; Heart Failure, Diastolic; Hypertrophy, Right Ventricular; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Single Photon Emission Computed Tomography Computed Tomography
- View Lab Website
YTRIC
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie Thorn's published research.
Publications Timeline
A big-picture view of Stephanie Thorn's research output by year.
Research Interests
Research topics Stephanie Thorn is interested in exploring.
Albert Sinusas, MD
Chi Liu, PhD
Edward J Miller, MD, PhD
Santiago Callegari, MD
Yi-Hwa Liu, PhD
Alaa Alashi, MD, MHS
74Publications
1,447Citations
Myocardial Infarction
Single Photon Emission Computed Tomography Computed Tomography
Radionuclide Imaging
Positron Emission Tomography Computed Tomography
Heart Failure
Myocardial Reperfusion Injury
Publications
2024
New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionCoordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, 71: 3312-3323. PMID: 38941195, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchConceptsPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyMolecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease
Jang S, Thorn S, Zohora F, Porcaro O, Burns R, Vermillion B, Callegari S, Guerrera N, DePino A, Liu C, Luna-Gutierrez M, Ferro-Flores G, Sinusas A. Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease. Journal Of Nuclear Cardiology 2024, 38: 101997. DOI: 10.1016/j.nuclcard.2024.101997.Peer-Reviewed Original ResearchHybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner
Thorn S, Burns R, Zohora F, Jang S, Porcaro O, Guerrera N, DePino A, Vermillion B, Liu C, Luna-Gutiérrez M, Ferro-Flores G, Sinusas A. Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner. Journal Of Nuclear Cardiology 2024, 38: 101972. DOI: 10.1016/j.nuclcard.2024.101972.Peer-Reviewed Original ResearchDevelopment Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.Peer-Reviewed Original ResearchNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchEarly Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition
Zohora F, Lee S, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Guerrera N, Thorn S, Sinusas A. Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition. Journal Of Cardiovascular Computed Tomography 2024, 18: s25-s26. DOI: 10.1016/j.jcct.2024.05.058.Peer-Reviewed Original ResearchCitationsComparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchCitationsConceptsPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomographyLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaMulti-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography
Ta K, Ahn S, Thorn S, Stendahl J, Zhang X, Langdon J, Staib L, Sinusas A, Duncan J. Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography. IEEE Transactions On Medical Imaging 2024, 43: 2010-2020. PMID: 38231820, PMCID: PMC11514714, DOI: 10.1109/tmi.2024.3355383.Peer-Reviewed Original ResearchCitationsConceptsMulti-task learning networkCross-stitch unitsComposite loss functionAccurate motion estimationTask-specific networksMotion estimationSegmentation masksLearning networkLoss functionSegmentation stepEchocardiography datasetNetworkMotion displacementMotion analysisMultiple time framesTaskAnalysis pipelineSegmentsStrain measurementsDatasetRepresentation
Academic Achievements & Community Involvement
activity Hotspot Imaging in Cardiovascular Disease: Methodology of Image Acquisition and Tracer Quantification
Oral PresentationSociety of Nuclear Medicine and Molecular Imaging Annual MeetingDetails06/27/2023 - 06/27/2023Chicago, IL, United States
News & Links
Media
- Contrast CT images of a normal myocardium and one with right ventricle heart failure.
- Using non-invasive SPECT/CT hybrid imaging, the reduced perfusion area can be quantified. At 3-days post-ischemia, the same area shows an increase in the radiotracer uptake of the matrix metalloproteinase agent, Tc-99m RP805. This tracer is an index of cardiac remodeling.
News
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
- March 18, 2024
Meet Yale Internal Medicine: Stephanie Thorn, MSc, PhD
- January 16, 2024
Yale's Cardiac Imaging Center Revolutionizes Translational Research
- July 12, 2023
Image-guided Therapy Improves Cardiac Function Post-MI (Discoveries & Impact July 2023)
Get In Touch
Contacts
Academic Office Number
Lab Number
Mailing Address
Yale School of Medicine
PO Box 208017, DANA 3
New Haven, CT 06520-8017
United States