Stephanie O'Malley, PhD
Elizabeth Mears and House Jameson Professor of PsychiatryDownloadHi-Res Photo
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Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
Appointments
Psychiatry
Primary
Additional Titles
Deputy Chair, Clinical Research
Contact Info
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States
About
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Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Deputy Chair, Clinical Research
Appointments
Psychiatry
ProfessorPrimary
Other Departments & Organizations
- ADVANCE Study
- Cancer Prevention and Control
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Center for the Translational Neuroscience of Alcohol
- Connecticut Mental Health Center
- Division of Addictions
- Division of Substance Abuse
- Division of Women's Behavioral Health Research
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Psychology Section
- Psychotherapy Development Center
- Smoking Cessation and Alcohol Treatment Research Clinic
- Stress & Addiction Clinical Research Program
- Substance Abuse Research
- Tobacco Research in Youth (TRY)
- Yale Cancer Center
- Yale Medicine
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
Education & Training
- PhD
- Vanderbilt University (1983)
- BS
- Vanderbilt University (1976)
Research
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Overview
Yale Tobacco Center for Regulatory Science
Clinical trials of varenicline for the treatment of alcohol dependence among smokers and of naltrexone for young adult heavy drinkers
Laboratory studies to evaluate medications for substance use disorders
Validation of biomarkers for monitoring drinking in clinical trials
Secondary analyses to identify moderators and predictors of response to treatments for alcohol dependence using tree based and trajectory analyses
Training of clinician and transdisciplinary scientists
Medical Research Interests
Alcoholism; Psychiatry; Psychiatry and Psychology; Risk Reduction Behavior; Smoking; Substance-Related Disorders
ORCID
0000-0002-1976-2369
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie O'Malley's published research.
Publications Timeline
A big-picture view of Stephanie O'Malley's research output by year.
Research Interests
Research topics Stephanie O'Malley is interested in exploring.
Suchitra Krishnan-Sarin, PhD
Krysten Bold, PhD
Lisa Fucito, PhD
Meghan Morean, PhD
Ralitza Gueorguieva, PhD
Kelly S. DeMartini, PhD
33Publications
279Citations
Publications
2026
From cool to non-cool: California’s ‘non-menthol’ cigarettes in 2025
Jabba S, Erythropel H, Anastas P, O’Malley S, Krishnan-Sarin S, Zimmerman J, Jordt S. From cool to non-cool: California’s ‘non-menthol’ cigarettes in 2025. Tobacco Prevention & Cessation 2026, 12: 1-5. PMID: 42211562, PMCID: PMC13215131, DOI: 10.18332/tpc/217322.Peer-Reviewed Original ResearchAltmetricConceptsWater addition to e-liquids to reduce flavour aldehyde acetal formation: chemistry and user sensory experience and appeal
Davis D, Green B, Krishnan-Sarin S, Martin T, Wu R, Gueorguieva R, Anastas P, Zimmerman J, O’Malley S, Allen W, Erythropel H. Water addition to e-liquids to reduce flavour aldehyde acetal formation: chemistry and user sensory experience and appeal. Tobacco Control 2026, tc-2025-060013. PMID: 42161504, PMCID: PMC13330406, DOI: 10.1136/tc-2025-060013.Peer-Reviewed Original ResearchAltmetric
2025
Oura Ring Behavioral Feedback Intervention for Alcohol Reduction in Young Adults: User Experience Evaluation of a Pilot Randomized Trial
Griffith F, Ellison O, Kunchay S, Augustine M, DeMartini K, Fatigate M, Latimer L, O'Malley S, Redeker N, Ash G, Fucito L. Oura Ring Behavioral Feedback Intervention for Alcohol Reduction in Young Adults: User Experience Evaluation of a Pilot Randomized Trial. Journal Of Medical Internet Research 2025, 27: e78613. PMID: 41343856, PMCID: PMC12677873, DOI: 10.2196/78613.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNatural language processingUser baseLanguage processingUser experience evaluationFeedback reportsSmartphone diariesGroup participantsOura ringYoung adult alcohol useFitness wearablesFace-to-face exit interviewFeedback interventionYoung adultsExperience evaluationPilot randomized controlled trialAlcohol reductionMobile appsMultiple intervention componentsSMS text messagesPilot Randomized TrialAppsConvergent mixed methodsBehavioral dataUsersRandomized Controlled TrialsReductions in World Health Organization Risk Drinking Levels as a Primary Efficacy End Point for Alcohol Clinical Trials
Witkiewitz K, Anton R, O’Malley S, Hasin D, Silverman B, Aldridge A, Mann K, Kranzler H, Aubin H, Hoffman M, Wong C, Meulien D, Zarkin G. Reductions in World Health Organization Risk Drinking Levels as a Primary Efficacy End Point for Alcohol Clinical Trials. JAMA Psychiatry 2025, 82: 1246-1254. PMID: 40960803, PMCID: PMC12739655, DOI: 10.1001/jamapsychiatry.2025.2508.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAlcohol use disorderWorld Health Organization risk drinking levelsAlcohol clinical trialsRisk drinking levelsDrinking reductionUse disorderDrinking levelsAlcohol use disorder treatmentAssociated with improvementsFood and Drug AdministrationRisk of substance use disordersGoal of abstinenceAlcohol-related consequencesSubstance use disordersOptimal outcome of treatmentClinical trialsPharmacotherapy trialsCommunity samplePsychiatric disordersActive medicationPsychiatric diseasesEnd pointsAlcohol fieldMedication developmentEffect sizeNew Reduced Drinking Goals in Alcohol Pharmacotherapy Trials—A Novel Public-Private Effort and FDA Approval Process
Anton R, O’Malley S, Mann K, Silverman B. New Reduced Drinking Goals in Alcohol Pharmacotherapy Trials—A Novel Public-Private Effort and FDA Approval Process. JAMA Psychiatry 2025, 82: 1159-1160. PMID: 40960805, DOI: 10.1001/jamapsychiatry.2025.2515.Peer-Reviewed Original ResearchCitationsAltmetricFeasibility and efficacy of a real-time smoking intervention using wearable technology
Bold K, Mestre L, Garrison K, Gueorguieva R, O'Malley S, Fucito L. Feasibility and efficacy of a real-time smoking intervention using wearable technology. PLOS Digital Health 2025, 4: e0001086. PMID: 41212887, PMCID: PMC12599971, DOI: 10.1371/journal.pdig.0001086.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTobacco treatmentOutpatient hospital settingSmoking behaviorHospital settingMeasures of smoking behaviorPoint prevalence abstinenceCessation outcomesExperimental groupSmoking interventionsQuit smokingControl groupSmoking cigarettesWearable technologyPreliminary efficacySmokingReal-time feedbackDays of treatmentCigaretteParticipantsAdultsLarge-scale clinical trialsAbstinenceSmartbandBehaviorTrends in Newly Filled GLP-1 Receptor Agonist Prescriptions for U.S. Patients With Versus Without Comorbid Alcohol Use Disorder, 2016 to 2024
Wallach J, O’Malley S, Lipska K, Ross J, Jeffery M, Savitz S. Trends in Newly Filled GLP-1 Receptor Agonist Prescriptions for U.S. Patients With Versus Without Comorbid Alcohol Use Disorder, 2016 to 2024. Journal Of Addiction Medicine 2025, 10.1097/adm.0000000000001575. PMID: 41036780, PMCID: PMC12636227, DOI: 10.1097/adm.0000000000001575.Peer-Reviewed Original ResearchCitationsConceptsComorbid alcohol use disorderAlcohol use disorderGLP-1RAClinical characteristicsGLP-1Use disorderGLP-1 receptor agonistsOptum Labs Data WarehouseAlcohol use disorder severityEmergency department visitsGLP-1RA prescriptionsNational claims dataType 2 diabetesReceptor agonistsDepartment visitsGLP-1RAsCharacteristics of individualsU.S. adultsUS patientsClinical studiesMA enrolleesClaims dataPharmacy claimsObesityMedical conditionsThe alcohol cue‐exposure paradigm as a screening tool for alcohol use disorder medication development: A critical review
Kirsch D, Grodin E, Leggio L, McKee S, Meredith L, Mereish E, Miranda R, Nieto S, O'Malley S, Schacht J, Ray L. The alcohol cue‐exposure paradigm as a screening tool for alcohol use disorder medication development: A critical review. Alcohol Clinical And Experimental Research 2025, 49: 2412-2426. PMID: 41017297, PMCID: PMC12638288, DOI: 10.1111/acer.70170.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAlcohol cue exposure paradigmCue exposure paradigmAlcohol use disorderMedication developmentCore symptomsBehavioral treatmentPharmacotherapy studiesUse disorderPredictive validityAUD pharmacotherapyScreening toolRegulatory approvalAlcoholParadigmIdentification of risk factorsNovel treatmentOutcome measuresCravingLarge-scale studiesRisk factorsNeurobiologyPharmacotherapyClinical applicationDisordersSymptomsWho is alcohol cue-reactive? A machine learning approach
Kirsch D, McManus K, Grodin E, Nieto S, Miranda R, O’Malley S, Schacht J, Ray L. Who is alcohol cue-reactive? A machine learning approach. Alcohol And Alcoholism 2025, 60: agaf052. PMID: 40838757, PMCID: PMC12368849, DOI: 10.1093/alcalc/agaf052.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAlcohol cue-reactivityAlcohol use disorderAlcohol cue exposure paradigmCue exposure paradigmCue-reactivityAlcohol urgesTonic cravingCue exposureCompulsive aspectsAlcohol cue exposureAlcohol Urge QuestionnaireBiological sexAlcohol cravingPre-cueUse disorderCravingSociodemographic predictorsUrgeCigarette useCigarette smoking statusAlcoholSociodemographic measuresPhenotypic overlapSmoking statusCigarette smokingA Randomized Trial of Alcohol Telemedicine in Primary Care: Pharmacotherapy and Referral Outcomes
Sterling S, Leibowitz A, Satre D, Cocohoba J, Kline-Simon A, Weisner C, Metz V, Ghadiali M, Corriveau C, O’Malley S, Awsare S, Morris M, Parthasarathy S. A Randomized Trial of Alcohol Telemedicine in Primary Care: Pharmacotherapy and Referral Outcomes. Journal Of General Internal Medicine 2025, 41: 6-15. PMID: 40634649, PMCID: PMC12855671, DOI: 10.1007/s11606-025-09708-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsReferral to specialty treatmentUnhealthy alcohol usePrimary care physiciansPrimary careAlcohol use disorderSpecialty treatmentUsual careAlcohol usePharmacist-delivered servicesPrimary care-basedAlcohol use disorder medicationsCluster randomized trialYear 2Alcohol use disorder diagnosisRandomized trialsCare-basedCare providersAlcohol use problemsImplementation outcomesIntervention armProvider characteristicsCare physiciansReferral outcomesTelemedicine consultationsReferral facilitation
Clinical Trials
Current Trials
Brief training for 18-26 year olds: Regulation of alcohol craving
IRB ID2000029394RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18 years - 26 years
Academic Achievements & Community Involvement
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Activities
activity Alcoholism:Clinical and Experimental Research
2011 - PresentProfessional OrganizationsMemberDetailsSenior Advisory Boardactivity American College of Neuropsychopharmacology/American Society of Clinical Psychopharmacology
2008 - PresentProfessional OrganizationsMemberDetailsWorking group on alcohol medication trial designactivity Psychiatry Investigation
2004 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity JAMA Psychiatry
2015 - PresentProfessional OrganizationsMemberDetailsEditorial Boardactivity NIDA
2015 - PresentCommitteesMemberDetailsData Safety Monitoring Board, Clinical Trials Network
Honors
honor Thwarp Award
11/01/2018National AwardFirst Tennessee Bank, Trustee under Will of James H. ThwarpDetailsUnited Stateshonor Distinguished Researcher Award
06/15/2018National AwardResearch Society on AlcoholismDetailsUnited Stateshonor Sidney J. Blatt Award
06/01/2015Yale School of Medicine AwardPsychology Section, Department of PsychiatryDetailsUnited Stateshonor Elected Member
04/01/2014Regional AwardConnecticut Academy of Science and Engineering (CASE)DetailsUnited Stateshonor Presidential Citation for Leadership and Research in the Field of Addictions
04/01/2014National AwardAmerican Psychological AssociationDetailsUnited States
News & Links
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News
- July 18, 2025Source: Yale News
For Young Adults, Improved Sleep Is Incentive to Drink Less
- June 26, 2025Source: Tobacco Control
Effects of Oral Nicotine Pouches on Cigarette Smoking Behavior and Tobacco Harm Exposure: A Randomised Pilot Trial in Adults
- December 03, 2024Source: Nature Digital Medicine
Natural Language Processing in Mixed-Methods Evaluation of a Digital Sleep-Alcohol Intervention For Young Adults
- September 26, 2024
Yale Study: Digital Cognitive Behavioral Therapy Program Found More Effective Than Clinician-Delivered Therapy at Reducing Alcohol Use in a Clinical Trial
Get In Touch
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Contacts
Mailing Address
Psychiatry
Connecticut Mental Health Center - SAC 202, 34 Park Street
New Haven, CT 06508
United States