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INFORMATION FOR

Guido J. Falcone, ScD, MPH

Associate Professor of Neurology
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Additional Titles

Academic Chief, Division of Neurocritical Care, Neurology

Director of Clinical Research in Neurocritical Care, Neurology

Training Director, Yale/AHA Bugher Center for Intracerebral Hemorrhage Research, Neurology

Staff Neurointensivist, Neurology

About

Titles

Associate Professor of Neurology

Academic Chief, Division of Neurocritical Care, Neurology; Director of Clinical Research in Neurocritical Care, Neurology; Training Director, Yale/AHA Bugher Center for Intracerebral Hemorrhage Research, Neurology; Staff Neurointensivist, Neurology

Biography

I am a Neurologist with subspecialty training in Neurocritical Care and Stroke, and an Epidemiologist with expertise in Population Genetics and Big Data. While on clinical duties, I treat critically ill patients that have sustained a significant neurological injury due to ischemic stroke, subarachnoid hemorrhage, intraparenchymal hemorrhage, traumatic brain injury, seizures, recent neurosurgery, decompensated neuromuscular diseases, and several others.

My research lies at the interphase of clinical neurology, neuroimaging, population genetics and genomic medicine. I am interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, I work in close collaboration with numerous investigators interested in stroke genomics from around the world.

Last Updated on April 07, 2025.

Appointments

  • Neurology

    Associate Professor on Term
    Primary
    Neurology

Other Departments & Organizations

Education & Training

Neurocritical Care Fellowship
Harvard Medical School / Massachusetts General Hospital / Brigham and Women's Hospital
ScD
Harvard School of Public Health, Department of Epidemiology
MPH
Harvard School of Public Health, Quantitative Methods
Neurology Residency
F.L.E.N.I.
MD
University of Buenos Aires

Research

Research at a Glance

Yale Co-Authors

Frequent collaborators of Guido J. Falcone's published research.

Publications

2026

See All Publications

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

Honors

  • honor

    Yale Office for Postdoctoral Affairs’ Annual Mentorship Award

    06/06/2024Yale University AwardYale Postdoctoral Association
  • honor

    Paul Dudley White International Scholar Award (last author) - Highest ranking abstract from the United States submitted to the 2022 International Stroke Conference

    02/13/2022International AwardAmerican Heart Association
  • honor

    Michael S. Pessin Stroke Leadership Prize

    04/19/2021National AwardAmerican Academy of Neurology
  • honor

    Get With The Guidelines (Stroke) Early Career Investigator Award

    12/01/2020International AwardAmerican Heart Association
  • honor

    American Society of Clinical Investigation Young Physician-Scientist Award

    02/21/2020National AwardAmerican Society of Clinical Investigation
View full list of honors

Clinical Care

Overview

Guido Falcone, MD, ScD, MPH, is a critical care neurologist who treats patients with severe brain injuries from trauma, strokes, hemorrhages, and seizures, among other conditions. “I usually meet patients with these injuries immediately after they come to the hospital,” Dr. Falcone says. He also sees patients suffering from symptoms caused by neuromuscular diseases or complications from brain surgery.

“One important characteristic of our specialty is that many important decisions need to be made in those initial few minutes to hours,” Dr. Falcone says. “We also need to factor in the patient’s wishes, but often they are unconscious and cannot communicate.”

In those cases, Dr. Falcone relies on the patient’s family for guidance. “This can cause a tremendous amount of stress as they carry the huge responsibility of representing their loved ones,” he says.

Dr. Falcone keeps this additional stress in mind when he’s talking with the patient’s family about a diagnosis and what to expect next. “It’s very important for us to be honest and explain to them what we know and don’t know so that this uncertainty can be taken into consideration when we’re making a clinical decision,” he says. Dr. Falcone says he and his colleagues in the Neuroscience Intensive Care Unit (Neuro ICU) frequently update families on the status of a patient’s condition and progress.

“Something I came to realize after a few years in the field is that we help patients and families all the time. Sometimes, we help them get better,” Dr. Falcone says. “But another important part of our job is to give the very best end-of-life care, with the same approach we use when curing a disease or saving lives, if that is necessary.”

In his research, Dr. Falcone specializes in population genetics and genomic medicine, two related fields that involve analyzing large amounts of data and searching for different variants of genes that might influence human disease. He works with a team that uses information from across disciplines, such as neuroimaging data, for example, to conduct studies. “We want to use data to understand not just what causes disease, but also who is at high risk of developing it,” Dr. Falcone says. “Genes are such a powerful tool in patient care because our genetic information is constant from birth.”

Clinical Specialties

Neurocritical Care; Neurology; Stroke; Brain Injury; Neuroradiology

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Locations

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