Chenxi Huang
Associate Research ScientistCards
About
Research
Publications
2025
Changes in Cardiovascular Risk Factors in U.S. Adults Before and After the COVID-19 Pandemic
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Essa M, Malik D, Li Z, Krumholz H, Lu Y. Changes in Cardiovascular Risk Factors in U.S. Adults Before and After the COVID-19 Pandemic. JACC Advances 2025, 4: 102352. PMID: 41240511, PMCID: PMC12664018, DOI: 10.1016/j.jacadv.2025.102352.Peer-Reviewed Original ResearchReply Aspirin for Secondary Prevention: Are Patients Getting Wiser Than Their Physicians?
Murugiah K, See C, Huang C. Reply Aspirin for Secondary Prevention: Are Patients Getting Wiser Than Their Physicians? JACC Advances 2025, 4: 102309. PMID: 41167122, PMCID: PMC12613007, DOI: 10.1016/j.jacadv.2025.102309.Peer-Reviewed Original ResearchMoving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care
Jain S, Mortazavi B, Chan You S, Yao X, Lam C, Elias P, Poterucha T, Avram R, Tison G, Pirruccello J, Huang C, Wiens J, Schwamm L, Ruan X, Dunn J, Luo Y, Spatz E, Krumholz H. Moving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care. Journal Of The American College Of Cardiology 2025, 86: 691-695. PMID: 40903130, DOI: 10.1016/j.jacc.2025.07.040.Peer-Reviewed Original ResearchAssociation Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
Brush J, Kim C, Liu Y, Xin X, Huang C, Lundy I, Asher J, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Krumholz H, Lu Y. Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes. JACC Advances 2025, 4: 101912. PMID: 40627892, PMCID: PMC12272890, DOI: 10.1016/j.jacadv.2025.101912.Peer-Reviewed Original ResearchNeighborhood-level social vulnerabilitySocial Vulnerability IndexAssociated with hypertension prevalenceDiverse cohortSocial Vulnerability Index quartilesElectronic health dataIncident myocardial infarctionBaseline body mass indexDiverse cohort of patientsSocial vulnerabilityBody mass indexPoor BP controlCardiovascular outcomesHypertension prevalenceBlood pressureHypertension outcomesRacial disparitiesHealth dataHypertension managementAssociated with adverse cardiovascular outcomesLongitudinal cohortMass indexWhite raceBlack raceComposite endpointDelayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
Lu Y, Brush J, Kim C, Liu Y, Xin X, Huang C, Sawano M, Young P, McPadden J, Anderson M, Burrows J, Asher J, Krumholz H. Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes. JAMA Network Open 2025, 8: e2520498. PMID: 40658418, PMCID: PMC12261005, DOI: 10.1001/jamanetworkopen.2025.20498.Peer-Reviewed Original ResearchConceptsElectronic health recordsHypertension diagnosisIntegrated health care systemHazard ratioNon-Hispanic black raceAntihypertensive medication prescribingMedication prescription ratesClinical diagnosis of hypertensionHealth care systemCardiovascular outcomesRisk of myocardial infarctionCox proportional hazards regression modelsAssociated with younger ageOutpatient blood pressureBlood pressureCardiovascular riskProportional hazards regression modelsAntihypertensive medication prescriptionsDiagnosis of hypertensionMultivariate Cox proportional hazards regression modelsAssociated with delayHazards regression modelsMedication prescribingHealth recordsNon-HispanicTowards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention
Hurley N, Desai N, Dhruva S, Khera R, Schulz W, Huang C, Curtis J, Masoudi F, Rumsfeld J, Negahban S, Krumholz H, Mortazavi B. Towards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention. PLOS Digital Health 2025, 4: e0000906. PMID: 40560847, PMCID: PMC12193038, DOI: 10.1371/journal.pdig.0000906.Peer-Reviewed Original ResearchNational Cardiovascular Data RegistryPercutaneous coronary interventionPrescription of medicationsRisk predictionArea under the receiver operating characteristic curveRisk prediction modelTreatment decision makingIndividualized carePatient dischargeData registryRisk estimatesRisk modelPrimary outcomeIndex admissionRisk informationModerate riskCoronary interventionPercutaneous coronary intervention proceduresRisk factorsPatient characteristicsIn-hospital bleeding eventsHigh riskLow riskMedical historyRegistryTrends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.Peer-Reviewed Original ResearchConceptsLife's Essential 8 scoreLife's Essential 8Cross-sectional studyWhite differencesEthnic differencesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySleep health scoreNutrition Examination SurveyGroup-specific interventionsPrimary positive factorPhysical activityExamination SurveyHealth scoresBlack adultsWhite adultsMain OutcomesAsian adultsOverall scoreEvaluate trendsNicotine exposureEssential 8Blood lipidsAdultsEthnic groupsInfection Specific Versus General Early Warning Scores for Predicting Sepsis on a Medical-Surgical Ward: A Multicenter Analysis
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Infection Specific Versus General Early Warning Scores for Predicting Sepsis on a Medical-Surgical Ward: A Multicenter Analysis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5678-a5678. DOI: 10.1164/ajrccm.2025.211.abstracts.a5678.Peer-Reviewed Original ResearchRecent Trends in Aspirin Use for Cardiovascular Disease Prevention in the United States, 2015 to 2023
Murugiah K, See C, Huang C. Recent Trends in Aspirin Use for Cardiovascular Disease Prevention in the United States, 2015 to 2023. JACC Advances 2025, 4: 101699. PMID: 40243986, PMCID: PMC12277617, DOI: 10.1016/j.jacadv.2025.101699.Peer-Reviewed Original ResearchBLOOD PRESSURE AND MORTALITY IN THE ADULTS AGED 80 OR OLDER: A COMPREHENSIVE ANALYSIS OF NATIONAL SURVEYS IN THE UNITED STATES
Yang H, Huang C, Sawano M, Herrin J, Li Z, Spatz E, Krumholz H, Lu Y. BLOOD PRESSURE AND MORTALITY IN THE ADULTS AGED 80 OR OLDER: A COMPREHENSIVE ANALYSIS OF NATIONAL SURVEYS IN THE UNITED STATES. Journal Of The American College Of Cardiology 2025, 85: 436. DOI: 10.1016/s0735-1097(25)00920-9.Peer-Reviewed Original Research
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