Yuan Lu, ScD
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)Cards
Appointments
Additional Titles
Director of Research, Preventive Cardiovascular Health Program
Contact Info
Appointments
Additional Titles
Director of Research, Preventive Cardiovascular Health Program
Contact Info
Appointments
Additional Titles
Director of Research, Preventive Cardiovascular Health Program
Contact Info
About
Titles
Assistant Professor of Medicine (Cardiology) and of Biomedical Informatics and Data Science and of Epidemiology (Chronic Diseases)
Director of Research, Preventive Cardiovascular Health Program
Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, health equity, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care, outcomes, and equity of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 150 peer-reviewed publications, including first author articles in leading journals such as The Lancet, JAMA, BMJ, Circulation, and JACC, and her work has been cited more than 50,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension. She is a Fellow of the American Heart Association and the American College of Cardiology, and currently serves as an Executive Associate Editor at JACC.
Appointments
Cardiovascular Medicine
Assistant ProfessorPrimaryBiomedical Informatics & Data Science
Assistant ProfessorSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Rohan Khera, MD, MS
Mitsuaki Sawano, MD, PhD
Shiwani Mahajan, MBBS, MHS
Jeph Herrin, PhD
Cardiovascular Diseases
Chronic Disease
Publications
2025
JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023)
Yan B, Arun A, Curtis L, Kadakia K, Lin Z, Lu Y, Wadhera R, Krumholz H, Dhruva S. JACC Data Report Cardiovascular Disease Mortality Trends in the United States (1999-2023). Journal Of The American College Of Cardiology 2025, 85: 2495-2498. PMID: 40562514, DOI: 10.1016/j.jacc.2025.05.018.Peer-Reviewed Original ResearchAltmetricDelayed Hypertension Diagnosis and Its Association with Cardiovascular Treatment and Outcomes
Lu Y, Brush JE Jr, Kim C, et al. Delayed hypertension diagnosis and its association with cardiovascular treatment and outcomes. JAMA Network Open. 2025;8(7):e2520498. doi:10.1001/jamanetworkopen.2025.20498Peer-Reviewed Original Research In PressChanges in cardiovascular risk factors and health care expenditure among patients prescribed semaglutide
Lu Y, Liu Y, Totojani T, et al. Changes in cardiovascular risk factors and health care expenditure among patients prescribed semaglutide. JAMA Network Open. 2025. In PressPeer-Reviewed Original Research In PressFrom Innovation to Implementation: Is PREVENT ready for clinical practice?
Lu Y, Nasir K. From Innovation to Implementation: Is PREVENT ready for clinical practice? J Am Coll Cardiol. 2025. In Press.Commentaries, Editorials and LettersDoes intensive blood pressure control affect how patients feel?
Lu Y, Spertus JA. Does intensive blood pressure control affect how patients feel? J Am Coll Cardiol. 2025. In Press.Commentaries, Editorials and LettersCoronary artery disease-based polygenic risk score in early-onset acute myocardial infarction subtypes
Dong W, Lu Y, Li S-X, Sawano M, Caraballo C, Liu Y, Khera A, Philippakis A, Dreyer R, Lichtman J, D'Onofrio G, Spatz ES, Herrington D, Post WS, Rich SS, Rotter JI, Krumholz HM. Coronary artery disease-based polygenic risk score in early-onset acute myocardial infarction subtypes. JACC: Advances. 2025. In Press.Peer-Reviewed Original Research In PressUptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
Kim C, Ross J, Jastreboff A, Meeker D, Freedman H, Krumholz H, Lu Y. Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US. JAMA 2025, 333: 2203-2206. PMID: 40299371, PMCID: PMC12042086, DOI: 10.1001/jama.2025.4735.Peer-Reviewed Original ResearchCitationsAltmetricUpdate to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000–2023
Arun AS, Sawano M, Lu Y, Warner F, Caraballo C, Khera R, Echols MR, Yancy CW, Krumholz HM. Update to the JACC Report Card: Excess Cardiovascular Mortality Among Black Americans, 2000–2023. Journal of the American College of Cardiology. 2025 Jun 19.Commentaries, Editorials and LettersLeveraging Global Data to Illuminate Pediatric Heart Failure Promise, Gaps, and the Path Forward
Lu Y. Leveraging Global Data to Illuminate Pediatric Heart Failure Promise, Gaps, and the Path Forward. JACC Heart Failure 2025, 13: 102500. PMID: 40540985, DOI: 10.1016/j.jchf.2025.04.011.Peer-Reviewed Original ResearchLipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Lipid-Lowering Therapy in the U.S. Adults Before and After the COVID-19 Pandemic. JACC Advances 2025, 4: 101872. PMID: 40513221, PMCID: PMC12205634, DOI: 10.1016/j.jacadv.2025.101872.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Activities
activity National Institutes of Health (NIH)
06/01/2023 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity JACC
02/01/2024 - PresentJournal ServiceAssociate Editoractivity American Heart Association
07/01/2021 - PresentProfessional OrganizationsFellowactivity JACC
07/01/2024 - PresentJournal ServiceAssociate Editoractivity American College of Cardiology
03/01/2025 - PresentProfessional OrganizationsFellow
Honors
honor Fellow
03/01/2025National AwardAmerican College of CardiologyDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence, Finalist
02/23/2024Yale School of Medicine AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence
02/01/2023Yale University AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor The John Laragh Research Award
07/29/2022National AwardAmerican Journal of HypertensionDetailsUnited Stateshonor Batten Fellowship Award
07/01/2022Regional AwardSentara FoundationDetailsUnited States
Teaching & Mentoring
Teaching
Didactic CDE 582 Health Outcomes Research
LecturerLecture SettingDetails02/01/2023 - PresentForGraduate3 Average Instructional Hours Per Year
Mentoring
Chungsoo Kim, PharmD/PhD
Postdoc2024 - PresentIvan Wu
Postgrad associate2024 - PresentAdith Arun
Medical student2024 - PresentXin Xin
Graduate student2023 - 2024
News
News
- June 03, 2025Source: Yale News
Insights & Outcomes: Star Music, Kavli Kudos, and Summertime Heart Risks
- May 05, 2025
Why Aren’t People Who Need Weight Loss Drugs Getting Them?
- April 17, 2025
Lower Blood Pressure May Offer Benefits Even for the Very Elderly
- March 19, 2025Source: HealthDay
Seniors Benefit from Tight Blood Pressure Control
Get In Touch
Contacts
Locations
Yale Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Fl 5th
New Haven, CT 06510