Nim Tottenham
Associate Professor, Adjunct in the Child Study Center, Yale School of MedicineAbout
Titles
Associate Professor, Adjunct in the Child Study Center, Yale School of Medicine
Biography
Nim Tottenham, Ph.D. uses magnetic resonance imaging and behavioral methods to examine the development of the human amygdala and its neural connections and associated emotional development, including emotional reactivity and management with the aim of identifying sensitive periods for human amygdala-cortical development. She examines limbic-cortical development in both typical groups of children and adolescents and those who have experienced early life adversity. She is a recipient of the American Psychological Association’s Distinguished Scientific Award for Early Career Contribution to Psychology, the National Institute of Mental Health Biobehavioral Research Awards for Innovative New Scientists (BRAINS) Award, and the Developmental Science Early Career Researcher Prize. She received her bachelor’s degree in Psychology from Barnard College of Columbia University and her doctoral degree from the University of Minnesota. She received postdoctoral training from the Sackler Institute for Developmental Psychobiology at Weill Cornell Medical College. More information on her research and laboratory can be found at: http://tottenhamlab.psych.ucla.edu/.
Appointments
Child Study Center
Associate Professor AdjunctPrimary
Other Departments & Organizations
Research
Publications
2024
On the role of familiarity and developmental exposure in music-evoked autobiographical memories
Kathios N, Bloom P, Singh A, Bartlett E, Algharazi S, Siegelman M, Shen F, Beresford L, DiMaggio-Potter M, Bennett S, Natarajan N, Ou Y, Loui P, Aly M, Tottenham N. On the role of familiarity and developmental exposure in music-evoked autobiographical memories. Memory 2024, ahead-of-print: 1-15. PMID: 39495656, DOI: 10.1080/09658211.2024.2420973.Peer-Reviewed Original ResearchMusic-evoked autobiographical memoriesCue autobiographical memoriesAutobiographical memoryPerceptions of familiarityFamiliar musicMusic familiarityMusic listeningMusic clipsMusicSelf-reported familiarityListenersFamiliarity ratingsCognitively healthy older adultsHealthy older adultsFamiliarityOlder adultsParticipating adolescentsMemoryClipsYoung adulthoodParticipantsAffectPerceptionMiddle childhoodYouthChildhood neglect is associated with alterations in neural prediction error signaling and the response to novelty.
Aloi J, Crum K, Blair K, Zhang R, Bashford-Largo J, Bajaj S, Hwang S, Averbeck B, Tottenham N, Dobbertin M, Blair R. Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty. Psychological Medicine 2024, 1-9. PMID: 39445510, DOI: 10.1017/s0033291724002411.Peer-Reviewed Original ResearchReward prediction errorEarly life stressLateral frontal cortexNovelty taskFrontal cortexNovel stimuliNeural prediction error signalsBlood oxygen level-dependent responsesAdolescents exposed to high levelsFunctional magnetic resonance imagingResponse to rewardChildhood Trauma QuestionnairePrediction error signalsLevel-dependent responsesAssociated with impairmentAssociation of abuseLevels of abuseReward responsivenessNeural differencesTrauma QuestionnaireChildhood neglectInstrumental learningLife stressBehavioral impairmentsMonetary rewardsProbing the content of affective semantic memory following caregiving‐related early adversity
Vannucci A, Fields A, Bloom P, Camacho N, Choy T, Durazi A, Hadis S, Harmon C, Heleniak C, VanTieghem M, Dozier M, Milham M, Ghetti S, Tottenham N. Probing the content of affective semantic memory following caregiving‐related early adversity. Developmental Science 2024, 27: e13518. PMID: 38664866, PMCID: PMC11489028, DOI: 10.1111/desc.13518.Peer-Reviewed Original ResearchSemantic memoryAttachment securityParent-child interactionsCaregiving adversityEarly adversityAttachment experiencesCognitive neuroscience frameworkFalse memory taskEarly caregiving adversityInternal working modelsMemory taskAttachment schemasNeuroscience frameworkFalse recognitionPreregistered studyBowlby's notionChild reportsSchema representationPotential malleabilityAdverse exposuresSchema knowledgeCognitive scienceParental-reportMemoryAdversityThe effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study
Abramson L, Callaghan B, Silvers J, Choy T, VanTieghem M, Vannucci A, Fields A, Tottenham N. The effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study. Developmental Science 2024, 27: e13505. PMID: 38549194, PMCID: PMC11436486, DOI: 10.1111/desc.13505.Peer-Reviewed Original ResearchMedial prefrontal cortexMedial prefrontal cortex activationFear conditioning taskFear learningUnconditioned stimulusMPFC activityAmygdala activationConditioning taskUnconditioned responseConditioned threat cueConditioned fear stimuliChildren's stress responsesMultiple comparison correctionThreat cuesFear conditioningPrefrontal cortexSafety cuesAversive stimuliFearful stimuliAversive noiseBehavioral effectsRodent findingsStress responseBOLD activityUS presentationsPreliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial.
Korom M, Valadez E, Tottenham N, Dozier M, Spielberg J. Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial. Development And Psychopathology 2024, 1-9. PMID: 38247369, PMCID: PMC11260902, DOI: 10.1017/s0954579423001669.Peer-Reviewed Original ResearchResting-state functional connectivityMiddle childhoodFunctional connectivityResting-state functional MRI scansChildren's emotion regulationFunctional MRI scansChild protective servicesRs-FC analysisEarly parenting interventionsCPS-involved familiesEmotion regulationRs-FCSeed-based RS FC analysisFoster care programsEvidence-based parenting programsParenting interventionsHigh-risk childrenGroup-level predictorsComparison groupParenting programsGroup of familiesMRI scansChildrenRandomized clinical trialsChildhood
2023
A Brain-Behavior Interaction Analysis for Dyadic Brain Responses during Eye Contact between Parents and Children
Lee R, Friedman J, O'Brien M, Ren Z, Hong L, Sajda P, Tottenham N. A Brain-Behavior Interaction Analysis for Dyadic Brain Responses during Eye Contact between Parents and Children. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/1027.Peer-Reviewed Original ResearchAffective Brain Development in Concert with Caregivers
Tottenham N. Affective Brain Development in Concert with Caregivers. 2023, 00: 1-1. DOI: 10.1109/aciiw59127.2023.10388104.Peer-Reviewed Original ResearchBrain developmentHuman brain developmentChildren's brain developmentDevelopmental sensitive periodsAffecting brain developmentAge-related changesCaregiving environmentAffective behaviorAffective learningEnvironmental influencesSensitive periodParent caregiversProlonged developmentSocial environmentCaregiversNeurocircuitryChildrenLearning