Luis Farhat, MD, PhD
Associate Research Scientist in the Child Study CenterCards
About
Research
Publications
2025
Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis
Shakeshaft A, Farhat L, Dennison C, Eyre O, Oginni O, O'Donovan M, Stringaris A, Leibenluft E, Polanczyk G, Riglin L, Thapar A. Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. Journal Of Child Psychology And Psychiatry 2025 PMID: 40974183, DOI: 10.1111/jcpp.70040.Peer-Reviewed Original ResearchShort Mood and Feelings QuestionnaireMillennium Cohort StudyStrengths and Difficulties QuestionnaireAvon Longitudinal StudyPolygenic scoresOdd-itemBehavior problemsCore symptomsMood and Feelings QuestionnaireAvon Longitudinal Study of ParentsAdolescent mental health servicesDepression polygenic scoresLongitudinal Study of ParentsCore symptoms of ADHDADHD polygenic scoresMental health servicesICD-11 approachOppositional defiant disorderSymptoms of ADHDStudy of parentsHealth servicesFeelings QuestionnaireADHD phenotypeAdolescent irritabilityMood disordersModerators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder
Farhat L, Sugaya L, Bloch M, Childress A, Cortese S, Fatori D, Salum G, Rohde L, Polanczyk G. Moderators of Response to Stimulants for Preschool Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40975435, DOI: 10.1016/j.jaac.2025.09.012.Peer-Reviewed Original ResearchADHD symptom severityAttention-deficit/hyperactivity disorderPreschool attention-deficit/hyperactivity disorderEfficacy of stimulationSymptom severityPost hoc natureRandomized placebo-controlled trialModerators of responseAttention-deficit/hyperactivitySymptom severity scoresPlacebo-controlled trialPredictor effectsPreschool childrenPreschoolOlder ageLinear mixed-effects modelsRandom-effects meta-analysesPlaceboMixed-effects modelsWhite childrenModeratelyTreatment effectsBlack childrenDisordersIndividual-level participant dataTrichotillomania and risk of alcohol- and drug-related problems
Farhat L, Isomura K, Kuja-Halkola R, Brikell I, Chang Z, D’Onofrio B, Larsson H, Lichtenstein P, de la Cruz L, Sidorchuk A, Mataix-Cols D. Trichotillomania and risk of alcohol- and drug-related problems. Biological Psychiatry Global Open Science 2025, 100605. DOI: 10.1016/j.bpsgos.2025.100605.Peer-Reviewed Original ResearchICD-10 diagnosisSubstance-related problemsRelative riskStratified Cox proportional hazard regressionsHazard ratioRisk of problematic substance useCox proportional hazards regressionDrug-related problemsProportional hazards regressionRisk of alcoholismProblematic substance useSociodemographic covariatesClinic registersICD-10Cohort studyHazards regressionPsychiatric historySubstance useDual diagnosisMatched individualsUnaffected individualsDiagnosis of trichotillomaniaPsychiatric disordersFollow-upPatient groupInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsSelf-reported family historyFamily history of mental health disordersFirst-degreeHistory of mental health disordersFamily historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHigher RatesHealth historyHealth disordersSurvey responsesAged 4Genetic studiesEtiological underpinningsTrichotillomaniaSmall studyAnxietyDepressionIndividualsComparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
Farhat L, Lannes A, Del Giovane C, Parlatini V, Garcia-Argibay M, Ostinelli E, Tomlinson A, Chang Z, Larsson H, Fava C, Montastruc F, Cipriani A, Revet A, Cortese S. Comparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. The Lancet Psychiatry 2025, 12: 355-365. PMID: 40203844, DOI: 10.1016/s2215-0366(25)00062-8.Peer-Reviewed Original ResearchConceptsRandomised controlled trialsSystolic blood pressureDiastolic blood pressureControlled TrialsAttention-deficit hyperactivity disorderNational Institute for Health and Care ResearchNetwork Meta-AnalysisMeta-analysisSystematic reviewEffects of ADHD medicationsWHO International Clinical Trials Registry PlatformBlood pressureCertainty of evidenceUK-based charityHaemodynamic valuesInternational Clinical Trials Registry PlatformClinical Trials Registry PlatformSafety of medicationsCare researchAssociated with decrementsTrials Registry PlatformRandom-effects network meta-analysesComparative cardiovascular safetyCardiovascular safetyDatabase inceptionBrief Internet-Delivered Cognitive-Behavioral Intervention for Children and Adolescents With Emotional Symptoms in Brazil: A Randomized Clinical Trial
Casella C, Farhat L, Labbadia E, Zuccolo P, Fatori D, Argeu A, Salum G, Polanczyk G. Brief Internet-Delivered Cognitive-Behavioral Intervention for Children and Adolescents With Emotional Symptoms in Brazil: A Randomized Clinical Trial. Journal Of Adolescent Health 2025, 77: 472-483. PMID: 40172510, DOI: 10.1016/j.jadohealth.2025.01.021.Peer-Reviewed Original ResearchConceptsCognitive-behavioral interventionsEmotional symptomsRCADS-PAnxiety and Depression ScaleRevised Children's Anxiety and Depression ScaleMental health careInternet-delivered interventionsStepped-care modelBaseline to post-treatmentPublic health contextPost-treatmentMiddle-income countriesFollow-up assessmentYouth aged 8Randomized Controlled TrialsDepression ScaleIntervention groupFollow-upHealth careDepression scoresDepressive symptomsHealth contextChild reportsPsychoeducational groupsAnxiety scoresMapping the Relationships between Dimensions of Child Anxiety, Parental Anxiety, and Family Accommodation: A Network Analysis
Macul Ferreira de Barros P, Farhat L, Polga N, Leckman J, Miguel E, Lebowitz E. Mapping the Relationships between Dimensions of Child Anxiety, Parental Anxiety, and Family Accommodation: A Network Analysis. Child Psychiatry & Human Development 2025, 1-8. PMID: 40146497, DOI: 10.1007/s10578-025-01831-5.Peer-Reviewed Original ResearchFamily accommodationAnxiety dimensionsSeparation anxietyParental anxietyMaintenance of child anxietyAssociated with separation anxietyPrimary anxiety disorderAnxiety disordersSocial anxietyChild anxietyAnxietyParental factorsClinical samplesChildrenDisordersAge groupsNetwork comparisonNetwork analysisRelationshipDimensionsCluster analysisParentsFamilyAccommodationSociodemographic and clinical characteristics of 1,234 individuals diagnosed with trichotillomania in the Swedish National Patient Register
Farhat L, Isomura K, Fernández de la Cruz L, Sidorchuk A, Kuja-Halkola R, Brikell I, Chang Z, D’Onofrio B, Larsson H, Lichtenstein P, Mataix-Cols D. Sociodemographic and clinical characteristics of 1,234 individuals diagnosed with trichotillomania in the Swedish National Patient Register. Scientific Reports 2025, 15: 10396. PMID: 40140525, PMCID: PMC11947438, DOI: 10.1038/s41598-025-95416-w.Peer-Reviewed Original ResearchConceptsSwedish National Patient RegisterICD-10 diagnosisDiagnosis of trichotillomaniaNational Patient RegisterPsychiatric disordersSpecialist servicesPatient RegisterDifficult-to-treat psychiatric disordersSwedish cohortAnxiety-related disordersComorbid psychiatric disordersClinical characteristicsRegister-based researchDepressive disorderCohort of individualsPsychotropic medicationsCharacteristics of individualsDispensed medicationsTrichotillomaniaTrichotillomania diagnosisICD-10Neurodevelopmental disordersDisordersDecember 31stStudy periodComparative efficacy and acceptability of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults: a systematic review and component network meta-analysis
Ostinelli E, Schulze M, Zangani C, Farhat L, Tomlinson A, Del Giovane C, Chamberlain S, Philipsen A, Young S, Cowen P, Bilbow A, Cipriani A, Cortese S. Comparative efficacy and acceptability of pharmacological, psychological, and neurostimulatory interventions for ADHD in adults: a systematic review and component network meta-analysis. The Lancet Psychiatry 2025, 12: 32-43. PMID: 39701638, DOI: 10.1016/s2215-0366(24)00360-2.Peer-Reviewed Original ResearchConceptsADHD core symptomsCore symptomsComponent network meta-analysisRandomised controlled trialsPsychological therapiesSelf-ReportCognitive behavioral therapyStandardised mean differenceDiagnosis of ADHDClinician-reported measuresTherapeutic componentsMental health conditionsNetwork Meta-AnalysisRandom-effects pairwiseTranscranial direct current stimulationCognitive remediationBehavioral therapyNational Institute for Health and Care ResearchCognitive trainingDirect current stimulationMeta-analysisOdds ratioADHDAtomoxetineRelevant lived experience
2024
Editorial: From adolescence into young adulthood – the importance of a longitudinal perspective across development in child and adolescent mental health
Koenig J, Farhat L, Bloch M. Editorial: From adolescence into young adulthood – the importance of a longitudinal perspective across development in child and adolescent mental health. Journal Of Child Psychology And Psychiatry 2024, 66: 1-3. PMID: 39690123, DOI: 10.1111/jcpp.14094.Peer-Reviewed Original ResearchConceptsDevelopmental trajectoriesYoung adulthoodJournal of Child PsychologyYoung adultsAdolescent mental healthRomantic partnersPsychiatric disordersChild psychologyIndividual well-beingDevelopmental periodMental healthEnvironmental demandsSocial interactionAdolescentsAdulthoodWell-beingLongitudinal perspectiveMaturational changesPersonsAdultsBiological changesPersonal lifePsychologyPsychiatryDisorders
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