Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsEuripedes C. Miguel, MD, PhD
Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of MedicineAbout
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Titles
Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of Medicine
Biography
Dr. Miguel is currently Professor & Chair of Child and Adolescent Psychiatry, Department of Psychiatry, University of São Paulo School of Medicine (USP). Through a network of professional associations established in the last decades, Eurípedes Miguel set up productive partnerships with the major university centers in the world, recently being appointed Adjunct Associate Professor of the Department of Psychiatry and Behavioral Sciences of the Duke University Medical Center, Adjunct Associate Professor of the Yale Child Study Center, Yale University School of Medicine and Consultant in Research at the Massachusetts General Hospital, Harvard Medical School. He was the founder and coordinator of the Obsessive-Compulsive Spectrum Disorders Program of the Institute of Psychiatry at USP (1994-2009) and is now the Coordinator of the National Institute for Developmental Psychiatry (www.inpd.org.br) focused on preventive measures for Children and Adolescents.
Appointments
Child Study Center
Associate Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- Harvard Medical School, Massachusetts General Hospital (1994)
- PhD
- University of São Paulo, Psychiatry Department (1992)
- MD
- University of Sao Paulo Medical School (1982)
Research
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Overview
- Comorbidities Trajectory in Obsessive-Compulsive Disorder
- Neural Circuits and Biological Markers Involved in Obsessive-Compulsive Behavior by Paradigms of Fear and Anxiety
- National Institute of Science and Technology Developmental Psychiatry for Children and adolescents
- A Multicenter Sequential Multiple Assignment Randomized Trial (SMART) for children with OCD
- Scholar High risk cohort study for the development of psychopathology and resilience – PREVENTION Study
- Butantã (SP) Birth Cohort
- Pregnant Women Cohort Study
Medical Research Interests
Public Health Interests
ORCID
0000-0002-9393-3103
Research at a Glance
Yale Co-Authors
Publications Timeline
James Leckman, MD, PhD
Thomas Fernandez, MD
Michael Bloch, MD, MS
Luis Farhat, MD, PhD
Christopher Pittenger, MD, PhD
Catherine Panter-Brick
Publications
2025
Attentional bias modification treatment for obsessive-compulsive disorder: a randomized clinical trial
Zanini Hendges N, Batistuzzo M, da Conceição Costa D, Bar-Haim Y, Abend R, Morais I, Salum G, Miguel E, Shavitt R, de Mathis M. Attentional bias modification treatment for obsessive-compulsive disorder: a randomized clinical trial. Journal Of Psychiatric Research 2025, 193: 431-440. PMID: 41385913, DOI: 10.1016/j.jpsychires.2025.12.013.Peer-Reviewed Original ResearchConceptsAttention Bias Modification TreatmentObsessive-compulsive disorderObsessive-compulsive disorder severityDouble-blind trialSeverity of obsessive-compulsive disorderThreat-related attentionAttentional bias scoresBaseline attentional biasesAttentional biasComputer-based interventionsNeuropsychiatric disordersBias scoresInconsistent findingsSham conditionModification treatmentRandomized clinical trialsDisordersSignificant changesIntra-group analysisPost-treatmentNo significant changesStatistically significant changesStimuliClinical scoresClinical trialsPredictive Validity of the Obsessive-Compulsive Inventory-4 and Florida Obsessive-Compulsive Inventory-II Severity Scale
Storch E, McCarty R, Zehavi M, Ahmad M, Cruz V, Berrones D, Muñoz J, Obando D, Barajas S, Frederick R, Anderberg J, Moore H, Ochoa-Panaifo M, Mallen M, Onyeka O, Wiese A, Sagarnaga M, McGuire J, Ferrão Y, Goodman W, Crowley J, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, Anciburo M, Anderberg J, Antich A, Aponte D, Londoño J, Espinosa A, Arellano-Ramírez L, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Avila-Vazquez A, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Boyle N, Muñoz D, Browning L, Burton C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Catano-Cedillo M, Cervin M, Chang A, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Costa C, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Prado P, del Río D, Dev A, Diaz S, Estrada F, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Giusti-Rodriguez P, González A, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Hernandez D, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Pedraza S, Jagannathan N, Jensen M, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Marques A, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McCarty R, McGuire J, McKay D, McOmber C, de Borja N, Minaya C, Miño T, Mithani S, Zambrana M, Moore H, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz J, Zabaleta M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Pavlinusich I, Paz y Miño M, de Leon E, Orellana J, Pereira S, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Qiao T, Quiroz-Padilla M, Correa M, Heros A, Valencia D, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Stewart S, Storch E, Tames-Bravo M, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Jardón C, Valentine K, Vallejo-Silva A, van Roessel P, Medrano J, Vásquez-Suyo M, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wagner K, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Albuquerque N, Alexandria R, Alves G, Alves-Pereira R, Artiga L, Azevedo J, Barbosa I, Bortoncello C, Cappi C, Carneiro B, Cervone F, Christo R, Costa D, Cupertino F, de Mathis M, de Menezes G, Dib L, do Rosário M, Dreher C, Félix-da-Silva C, Ferrão Y, Ferreira G, Ferreira L, Fontenelle L, Frota G, Gil M, Guarinon I, Hoexter M, Hounie A, Lima M, Martinho A, Mendes T, Merces J, Miguel E, Muniz A, Oliveira B, Passinho J, Quarantini L, Quarantini-Alvim Y, Ramos V, Sampaio A, Saraiva L, Sater P, Shavitt R, Silva O, Soares M, Souza V, Stumpf B, Tavares B. Predictive Validity of the Obsessive-Compulsive Inventory-4 and Florida Obsessive-Compulsive Inventory-II Severity Scale. Journal Of Psychiatric Research 2025 DOI: 10.1016/j.jpsychires.2025.12.011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSeverity ScaleObsessive-compulsive symptomatologySelf-report assessmentsDiagnostic InterviewPredictive validityScreening measuresAmerican adultsTreatment outcomesTransnational sampleAccurate screening toolEarly identificationResearch contextScreening toolSymptomatologyScaleDisordersComparative benefitsParticipantsAdultsScoresIndividualsSeverityRole of maternal immune response and placental exosomes in infant cognitive outcome at 12 months of age.
Gouveia G, Camilo C, Simões S, da Silva Braga C, Martinez R, Camoezi F, Moreira L, Euclydes V, Vilela L, Pereira J, Miguel E, Polanczyk G, Martins D, Brentani H. Role of maternal immune response and placental exosomes in infant cognitive outcome at 12 months of age. Journal Of Reproductive Immunology 2025, 173: 104806. PMID: 41308548, DOI: 10.1016/j.jri.2025.104806.Peer-Reviewed Original ResearchConceptsBayley Scales of Infant and Toddler Development-IIIPlacental exosomesNeurodevelopmental outcomesInfant sexMaternal cytokinesMaternal circulationIFN-gBayley ScalesIL-10IL-1BIL-6Maternal inflammatory stateMaternal immune responseMaternal-fetal crosstalkInfant neurodevelopmental outcomesMaternal cytokine levelsCytokines IFN-gCytokine IL-10Months of ageEffects of infant sexInfant cognitive outcomesLuminex technologyCytokine levelsInflammatory statePregnant adolescentsConnectivity Analysis of Brain Circuits Modulated by Electrical Stimulation of the Ventral Capsule and Ventral Striatum in Patients with Obsessive-Compulsive Disorder
Laube K, Iglesio R, Ricci Arantes P, Miguel E, Hoexter M, Junior Gilberto C, Carlos A, Carlos L, Godinho F. Connectivity Analysis of Brain Circuits Modulated by Electrical Stimulation of the Ventral Capsule and Ventral Striatum in Patients with Obsessive-Compulsive Disorder. NeuroTarget 2025, 19: 30. DOI: 10.47924/neurotarget2025508.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMedial orbitofrontal cortexYale-Brown Obsessive-Compulsive ScaleTreatment-resistant obsessive-compulsive disorderDeep brain stimulationDiffusion tensor imagingOccipital cortexConnectivity analysisPathophysiology of obsessive-compulsive disorderNeural circuitsObsessive-Compulsive ScaleVentral capsule/ventral striatumMiddle occipital cortexModulation of neural circuitsAnterior thalamic nucleiOrbitofrontal cortexSalience processingVentral striatumPostoperative CT scansBrain circuitsSymptom severityVentral capsuleCortical regionsAnterior thalamusAnterior limbModerating effects of childhood deprivation and threat on the relationship between polygenic score and internalizing symptoms: A longitudinal analysis
Oliveira A, Carvalho C, Ota V, Hoffmann M, Schafer J, Gomes Bugiga A, Pan P, Rohde L, Bressan R, Miguel E, Santoro M, Salum G, Belangero S. Moderating effects of childhood deprivation and threat on the relationship between polygenic score and internalizing symptoms: A longitudinal analysis. Psychiatry Research 2025, 355: 116825. PMID: 41240760, DOI: 10.1016/j.psychres.2025.116825.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPolygenic scoresGenetic riskIndividual’s polygenic scoreImpact of adverse childhood experiencesChildhood deprivationExpression of genetic riskStrengths and Difficulties QuestionnaireHigher polygenic scoreAdverse childhood experiencesInternalizing symptomsWell-Being AssessmentHigh deprivationMental healthDifficulties QuestionnairePRS-CSPsychiatric disorders in adulthoodChildhood experiencesGeneralized mixed modelsAged 9Well-beingLongitudinal analysisGenetic susceptibilityDisorders in adulthoodSex-specific interactionsAdverse eventsCohort Profile: Brazilian High-Risk Cohort for Mental Health Conditions (BHRC)
Salum G, de Giusti C, Souza L, Juk J, Costa R, Sugaya L, Caye A, Simioni A, Rocha P, Manfro G, Ito L, Da Silva F, Duarte I, Esper N, Anés M, Damiano R, Satterthwaite T, Carvalho C, Bado P, Hoffmann M, Schafer J, Casella C, Evans-Lacko S, Ziebold C, Rocha R, Zugman A, Jackowski A, Gadelha A, Hoexter M, Madruga C, Grassi-Oliveira R, Cattaneo A, Tyrka A, Paus T, Pine D, Leibenluft E, Stringaris A, Merikangas K, Milham M, Franco A, Santoro M, Sato J, Ota V, Polanczyk G, Mari J, Bressan R, Miguel E, Rohde L, Belangero S, Pan P. Cohort Profile: Brazilian High-Risk Cohort for Mental Health Conditions (BHRC). International Journal Of Epidemiology 2025, 54: dyaf192. PMID: 41241815, PMCID: PMC12619906, DOI: 10.1093/ije/dyaf192.Peer-Reviewed Original ResearchPatterns of substance use and initiation among LGBTQIAPN+ youth in Brazil: Evidence from a population-based cohort
Figueiredo C, Bezerra H, Miguel E, Rohde L, Salum G, Pan P, Caye A. Patterns of substance use and initiation among LGBTQIAPN+ youth in Brazil: Evidence from a population-based cohort. International Review Of Psychiatry 2025, 37: 639-650. PMID: 41104620, DOI: 10.1080/09540261.2025.2573758.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHigher lifetime prevalenceSubstance usePrevalence of tobaccoLifetime useMental health conditionsUnique psychosocial stressorsBrazilian High-Risk Cohort StudyHigh Risk Cohort StudyPopulation-based cohortCommunity-based studyMiddle-income countriesLifetime use of alcoholParticipants aged 9Onset of substance useUse of alcoholCisgender heterosexual peersGender minority youthPatterns of substance useCocaine useHealth conditionsCohort studyPsychosocial stressorsPrevention strategiesLifetime prevalenceElevated substance useT92. EXPLORING THE COMMON GENETIC BASE OF PSYCHIATRIC DISORDERS IN A BRAZILIAN COHORT OF RELATED INDIVIDUALS
Almodobar L, Mauer J, Torres-Loureiro S, Martins A, Rodrigues M, Oshiro C, Bressan R, Rohde L, Miguel E, Pan P, Salum G, Santoro M, Ota V, Carvalho C, Belangero S. T92. EXPLORING THE COMMON GENETIC BASE OF PSYCHIATRIC DISORDERS IN A BRAZILIAN COHORT OF RELATED INDIVIDUALS. European Neuropsychopharmacology 2025, 99: 206. DOI: 10.1016/j.euroneuro.2025.08.583.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle nucleotide variantsPolygenic scoresPolygenic score analysesOdds ratioPsychiatric disordersGenome-wide significant lociCross-disorder genome-wide association studyNature of psychiatric disordersBrazilian cohortGenome-wide correctionComplex nature of psychiatric disordersAssociated with psychiatric disordersOR increasePRS-CSTop SNPNominal significancePolygenic burdenAdmixed ancestrySignificant lociPD riskNucleotide variantsAssociation studiesEffect sizeNo significant results1. INTERACTION BETWEEN SUBSTANCE USE AND SNVS IN THE EMERGENCE OF PSYCHIATRIC DISORDERS
Destro P, Ito L, Ota V, Miguel E, Pan P, Bressan R, Salum G, Belangero S, Muniz C, Santoro M. 1. INTERACTION BETWEEN SUBSTANCE USE AND SNVS IN THE EMERGENCE OF PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2025, 99: 52. DOI: 10.1016/j.euroneuro.2025.08.106.Peer-Reviewed Original ResearchConceptsBrazilian High-Risk Cohort StudyDevelopment of psychiatric disordersPsychiatric disordersPsychotic experiencesLysergic acid diethylamideSubstance useAssociated with reduced riskCommunity Assessment of Psychic ExperiencesDSM-IV diagnostic criteriaAssociated with psychiatric disordersRates of cannabis useSusceptibility to psychiatric conditionsEffect sizeSubclinical psychotic symptomsClinical psychiatric disordersHigh Risk Cohort StudyCommunity assessmentDrug useRisk of ADHDPsychotic symptomsDSM-IVCannabis usersGenetic variantsPsychosis riskCannabis useM53. IMPACT OF COGNITION-RELATED COPY NUMBER VARIATIONS ON INTELLIGENCE QUOTIENT POLYGENIC SCORES IN A HIGHLY ADMIXED POPULATION
Arendt J, Ortunes D, Cuóco C, Ito L, Ota V, Miguel E, Pan P, Bressan R, Salum G, Belangero S, Santoro M. M53. IMPACT OF COGNITION-RELATED COPY NUMBER VARIATIONS ON INTELLIGENCE QUOTIENT POLYGENIC SCORES IN A HIGHLY ADMIXED POPULATION. European Neuropsychopharmacology 2025, 99: 135. DOI: 10.1016/j.euroneuro.2025.08.249.Peer-Reviewed Original ResearchConceptsProbability of loss-of-function intolerancePolygenic score predictionIntelligence quotientPolygenic scoresBrazilian High-Risk CohortCognitive ability measuresPrediction of IQPolygenic score associationsStandardized composite scoreLoss-of-function intolerant genesPathogenic CNVsLoss-of-function intoleranceCritical genesCognitive testsCognitive functionAbility measuresCognitive impairmentPolygenic score performanceComposite scoreDuplication carriersMental conditionValues of genesGene annotationIntolerant genesCNV burden
Academic Achievements & Community Involvement
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Activities
activity São Paulo University
12/01/2009 - PresentPublic ServiceChairpersonDetailsChairman on Department of Psychiatry of Medical School in São Paulo University.activity São Paulo University
2009 - PresentPublic ServiceProfessorDetailsProfessor of Psychiatry, Department of Psychiatry, University of São Paulo Medical Schoolactivity Developmental Psychiatry National Institute for Children and Adolescent
01/12/2009 - PresentProfessional OrganizationsPresidentDetailsPresident National Institute for Developmental Psychiatryactivity Institute of Psychiatry
2009 - PresentCommitteesMemberDetailsMember, Executive Committee of Institute of Psychiatry, University of São Pauloactivity São Paulo University
2009 - PresentPublic ServiceProfessorDetailsProfessor of Psychiatry
Honors
honor IPq Award
12/01/2007Yale University AwardThe best research in the Department & Institute of PsychiatryDetailsUnited Stateshonor Prof. Ulysses Vianna Filho’s Award
12/01/2006National AwardBrazilian Association of PsychiatryDetailsUnited Stateshonor V Psychiatry Week Award
12/01/2006National Award"Revista Psiquiatria ClínicaDetailsUnited Stateshonor Prof. Ulysses Vianna Filho’s Award
12/01/2005National AwardAssociação Brasileira de PsiquiatriaDetailsUnited Stateshonor OCDi AWARD
12/01/1996International AwardWorld Congress of PsychiatryDetailsUnited States
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