Adam Naples, PhD
Assistant Professor in the Child Study CenterCards
About
Research
Publications
2026
A longitudinal investigation of aggression and social skills in autistic youth
Rea H, Lindley A, Howard W, Neuhaus E, Faja S, Bernier R, Chawarska K, Dawson G, Dziura J, Jeste S, Kleinhans N, Naples A, Nelson C, Sabatos-Devito M, Seow H, Shic F, Sugar C, McPartland J, Webb S, Trials T. A longitudinal investigation of aggression and social skills in autistic youth. Research In Autism Spectrum Disorders 2026, 130: 202767. DOI: 10.1016/j.reia.2025.202767.Peer-Reviewed Original ResearchSelf-injurious behaviorSocial skillsConfirmatory factor analysisParallel-process growth modelAutistic childrenSchool-aged autistic childrenLongitudinal investigationMeasures of aggressionLevel of social skillsCo-occurring featuresAutistic individualsAutistic youthInvestigation of aggressionSocial functioningConclusions InterventionsAggressionFactor analysisInitial scoreSkillsChildrenAutismTime pointsBehaviorYouthScores
2025
Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism.
Naples A, Yang Y, Gravel P, Toyonaga T, Sadabad F, Koohsari S, Pittman B, Gallezot J, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Rodden I, Hillmer A, Esterlis I, Ropchan J, Nabulsi N, Huang Y, Wolf J, Carson R, McPartland J, Matuskey D. Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism. American Journal Of Psychiatry 2025, appiajp20241084. PMID: 41366835, DOI: 10.1176/appi.ajp.20241084.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Glutamate receptor 5Positron emission tomographyAutistic groupGroup differencesPositron emission tomography outcomes measurementsExcitatory neurotransmissionNeurotypical control participantsAutism spectrum disorderReceptor 5Receptor availabilityAutism phenotypeAutistic adultsBrain areasBrain regionsExcitatory neural activitySpectrum disorderControl participantsSensory sensitivityMGlu5Neural activityVenous input functionsReceptor densityAutismEEG power spectraReduced Social Prioritization: An Underlying Mechanism Driving Slower Latency to Look at Faces in Autism
Griffin J, Willis H, Dommer K, Naples A, Dawson G, Jeste S, Faja S, Bernier R, Kleinhans N, Levin A, Hellemann G, Senturk D, Dziura J, Sugar C, Webb S, McPartland J, Shic F. Reduced Social Prioritization: An Underlying Mechanism Driving Slower Latency to Look at Faces in Autism. Journal Of Psychopathology And Clinical Science 2025 PMID: 41100279, PMCID: PMC12616544, DOI: 10.1037/abn0001026.Peer-Reviewed Original ResearchNumber of alpha peaks in the electroencephalogram is associated with clinical phenotype and copy number variation in youths with autism
Arutiunian V, Opdahl M, Sullivan C, Santhosh M, Neuhaus E, Borland H, Bernier R, Bookheimer S, Dapretto M, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S, Gupta A. Number of alpha peaks in the electroencephalogram is associated with clinical phenotype and copy number variation in youths with autism. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 41101705, DOI: 10.1016/j.bpsc.2025.10.001.Peer-Reviewed Original ResearchCopy number variationsClinical phenotypeAlpha-band activityGenome-wide CNV analysisAssociated with clinical phenotypesNumber variationsResting-state EEGCNV analysisAutism spectrum disorderGenetic burdenBehavioral phenotypesPhenotypeAlphaNeural activityEEGAlpha peakCopyHigher presencePresence of autistic traitsSpectrum disorderFace perception, attention, and memory as predictors of social change in autistic children
Webb S, Kwan B, Bernier R, Charwarska K, Dawson G, Dziura J, Faja S, Hellmann G, Jeste S, Kleinhans N, Levin A, Naples A, Sabatos-DeVito M, Şentürk D, Shic F, Sugar C, McPartland J. Face perception, attention, and memory as predictors of social change in autistic children. Journal Of Neurodevelopmental Disorders 2025, 17: 54. PMID: 40885894, PMCID: PMC12398159, DOI: 10.1186/s11689-025-09646-0.Peer-Reviewed Original ResearchFace memoryN170 latencyFace memory taskEye trackingAutistic social behavioursNon-autistic childrenSocial behavior scoresMemory taskSocial cognitionUpright facesFace perceptionNaturalistic studySocial abilitiesSocial attentionChild behaviorSocial perceptionSocial behaviorAutistic childrenPredictive relationsBaseline performanceVisual attentionBehavior 4Social approachParent interviewsBehavior scoresLongitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials
Gerber A, Naples A, Chawarska K, Dawson G, Kleinhans N, Jeste S, Faja S, Dziura J, Webb S, Sugar C, Shic F, Levin A, McPartland J, Trials F. Longitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials. Psychological Medicine 2025, 55: e104. PMID: 40170613, PMCID: PMC12094631, DOI: 10.1017/s0033291725000650.Peer-Reviewed Original ResearchConceptsSocial anhedoniaSocial anxietyInternalizing symptomsAutistic childrenAutism severityCASI-5Parent-reported social anxietyAssociated with increased internalizing symptomsAutism Diagnostic Observation ScheduleCross-lagged panel modelBidirectional relationshipAttention-deficit/hyperactivity disorderBidirectional longitudinal associationsCross-lagged modelsAnhedonia subscaleAttention-deficit/hyperactivityAnhedoniaFifth editionReduced pleasureObservation ScheduleAutistic youthConcurrent relationshipsAutismLongitudinal relationshipDevelopmental model
2024
Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth
Franke C, Griffin J, Naples A, Wolf J, McPartland J. Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-13. PMID: 39556296, DOI: 10.1007/s10803-024-06636-4.Peer-Reviewed Original ResearchNon-autistic participantsSocial attentionSocial anxietyEye contactAutistic youthEyes of emotional facesSA characteristicsEye trackingReduced eye contactSelf-reported SAReduced visual attentionNon-autistic childrenEmotional facesAutistic participantsPsychiatric characteristicsNon-autistic youthAutistic individualsEmotional expressionVisual attentionEye regionBehavioral featuresSocial interactionAutismParticipantsCo-occurrence11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 30: 1610-1616. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutismClinician–caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children
Azu M, Han G, Wolf J, Naples A, Chawarska K, Dawson G, Bernier R, Jeste S, Dziura J, Webb S, Sugar C, Shic F, McPartland J. Clinician–caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children. Autism 2024, 29: 614-626. PMID: 39344965, PMCID: PMC11906266, DOI: 10.1177/13623613241279999.Peer-Reviewed Original ResearchAutism-related behaviorsAutism featuresClinician ratingsParent ratingsInformant discrepanciesCaregiver ratingsCaregiver reportsAutism diagnosisAutistic childrenChild sexAutismCaregiver perceptionsIntervention useClinicians' perceptionsAssociated with sexCaregiversChildrenDiagnosis ageCliniciansOlder ageInterventionPerceptionGirlsSexAgeCentral and peripheral physiological responses to decision making in hoarding disorder
Levy H, Naples A, Collett S, McPartland J, Tolin D. Central and peripheral physiological responses to decision making in hoarding disorder. International Journal Of Psychophysiology 2024, 205: 112437. PMID: 39265723, PMCID: PMC11502253, DOI: 10.1016/j.ijpsycho.2024.112437.Peer-Reviewed Original ResearchError-related negativityHoarding DisorderControl participantsAlpha asymmetryPsychophysiological responsesIncreased frontal negativityGo/No-Go taskHealthy control participantsDecision-making taskPeripheral nervous system activityResponse to decisionsAnxiety disordersFrontal negativityNeurobiological modelsGo taskNeutral taskPsychiatric diagnosisExcessive clutterPsychophysiological measuresPersonal possessionsExaggerated activationDisordersNull resultsNervous system activityTask
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