Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVittorio Gallo, PhD
About
Research
Publications
2025
Transformation of radial glia into postnatal neural stem cells depends on birth
Takemura S, Kawase K, Wolbeck L, Nakamura Y, Matsumoto M, Jinnou H, Tahara A, Sawada M, Kubota Y, Herranz-Pérez V, García-Verdugo J, Ishibashi N, Gallo V, Ohno N, Khodosevich K, Sawamoto K. Transformation of radial glia into postnatal neural stem cells depends on birth. Cell Reports 2025, 44: 116029. PMID: 40713958, DOI: 10.1016/j.celrep.2025.116029.Peer-Reviewed Original ResearchConceptsNeural stem cellsPostnatal neural stem cellsVentricular-subventricular zoneAdult neural stem cellsStem cellsRadial gliaNeural stem cell propertiesPostnatal stem cellsBlood vesselsTransformation of radial gliaPreterm birthFiber transectionCell interactionsBirthBirth processGliaBloodCellsBirth timingThree-dimensionalPretermThe shifting landscape of the preterm brain
Kratimenos P, Sanidas G, Simonti G, Byrd C, Gallo V. The shifting landscape of the preterm brain. Neuron 2025, 113: 2042-2064. PMID: 40239653, PMCID: PMC12245580, DOI: 10.1016/j.neuron.2025.03.024.Peer-Reviewed Original ResearchPreterm infantsGestational ageLong-term outcomes of preterm infantsLong-term neurodevelopmental consequencesOutcomes of preterm infantsPreterm brain injuryLong-term outcomesPreterm birth complicationsInvestigate therapeutic strategiesPreterm brainPreterm birthHypoxia-ischemiaIntracranial hemorrhageNeonatal careImpaired brain functionGlobal health concernPretermBirth complicationsOligodendrocyte injuryNon-pharmacological approachesUtero developmentTherapeutic strategiesSurvival rateInfantsBirth persistThe Science of Neurohabilitation and Neurodevelopmental Care for Infants with High-Risk Neonatal Illnesses
Erdei C, Gallo V, Maitre N, Spittle A, Inder T. The Science of Neurohabilitation and Neurodevelopmental Care for Infants with High-Risk Neonatal Illnesses. The Journal Of Pediatrics 2025, 282: 114582. PMID: 40221018, DOI: 10.1016/j.jpeds.2025.114582.Peer-Reviewed Original ResearchOuter radial glia promotes white matter regeneration after neonatal brain injury
Jinnou H, Rosko L, Yamashita S, Henmi S, Prasad J, Lam V, Agaronyan A, Tu T, Imamura Y, Kuboyama K, Sawamoto K, Hashimoto-Torii K, Ishibashi N, Gallo V. Outer radial glia promotes white matter regeneration after neonatal brain injury. Cell Reports Medicine 2025, 6: 101986. PMID: 40023165, PMCID: PMC11970391, DOI: 10.1016/j.xcrm.2025.101986.Peer-Reviewed Original ResearchConceptsOuter radial gliaActivating transcription factor 5Oligodendrocyte precursor cellsTreating white matter injuryNeonatal brain injuryWhite matter injuryPeriventricular white matterWhite matter regenerationImprove functional recoveryPopulation of neural stem cellsNeural stem cellsBrain injuryOuter subventricular zoneSubventricular zoneProliferative capacityPostnatal developmentVentricular zoneFunctional recoveryPrecursor cellsStem cellsWhite matterRadial gliaTherapeutic targetNeonatal pigletsInjurySignificance of birth in the maintenance of quiescent neural stem cells
Kawase K, Nakamura Y, Wolbeck L, Takemura S, Zaitsu K, Ando T, Jinnou H, Sawada M, Nakajima C, Rydbirk R, Gokenya S, Ito A, Fujiyama H, Saito A, Iguchi A, Kratimenos P, Ishibashi N, Gallo V, Iwata O, Saitoh S, Khodosevich K, Sawamoto K. Significance of birth in the maintenance of quiescent neural stem cells. Science Advances 2025, 11: eadn6377. PMID: 39841848, PMCID: PMC11753423, DOI: 10.1126/sciadv.adn6377.Peer-Reviewed Original ResearchConceptsNeural stem cellsQuiescent neural stem cellsStem cellsRadial gliaNeural stem cell poolAcquisition of quiescenceEmbryonic neural stem cellsPreterm birthPostnatal neural stem cellsCellular processesPostnatal neurogenesisGlutamine metabolismPostnatal brainLong-term maintenanceDevelopmental processesBirthNeurogenesisPretermCells
2024
Cerebellar Purkinje Cell Activity Regulates White Matter Response and Locomotor Function after Neonatal Hypoxia
Kundu S, Ghaemmaghami J, Sanidas G, Wolff N, Vij A, Byrd C, Simonti G, Triantafyllou M, Jablonska B, Dean T, Koutroulis I, Gallo V, Kratimenos P. Cerebellar Purkinje Cell Activity Regulates White Matter Response and Locomotor Function after Neonatal Hypoxia. Journal Of Neuroscience 2024, 45: e0899242024. PMID: 39472064, PMCID: PMC11694407, DOI: 10.1523/jneurosci.0899-24.2024.Peer-Reviewed Original ResearchWhite matter injuryNeonatal hypoxiaLocomotor deficitsPurkinje cellsWM injuryOligodendrocyte maturationCerebellar Purkinje cell activityNeuronal activitySurvivors of prematurityPC activityWhite matterTrimester of pregnancyCerebellar Purkinje cellsPurkinje cell activityRestoring neuronal activityLocomotor dysfunctionMultielectrode array recordingsHx miceOligodendrocyte precursor cellsPreterm neonatesPotential therapeutic interventionsNeonatal injuryGABAergic interneuronsCerebellar WMEffect of HXMesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy
Koutroulis I, Kratimenos P, Hoptay C, O’Brien W, Sanidas G, Byrd C, Triantafyllou M, Goldstein E, Jablonska B, Bharadwaj M, Gallo V, Freishtat R. Mesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy. IScience 2024, 27: 110573. PMID: 39165840, PMCID: PMC11334791, DOI: 10.1016/j.isci.2024.110573.Peer-Reviewed Original ResearchCentral nervous systemSeptic encephalopathyStem cell (MSC)-derived small extracellular vesiclesSmall extracellular vesiclesDysregulated host response to infectionRestored aerobic metabolismLife-threatening organ dysfunctionLong-term sequelaeHost response to infectionExtracellular vesiclesMesenchymal stem cell-derived small extracellular vesiclesPro-inflammatory cytokinesCell-derived small extracellular vesiclesResponse to infectionStem cell-derived small extracellular vesiclesImmune dysregulationOrgan dysfunctionSusceptible to injurySeptic miceClinical symptomsClinical severityImmunometabolic dysfunctionIntravenous administrationDisease outcomeInfectious processEach scar whispers a story
Gallo V, Kratimenos P. Each scar whispers a story. Nature Neuroscience 2024, 27: 1215-1216. PMID: 38849522, DOI: 10.1038/s41593-024-01665-9.Peer-Reviewed Original ResearchHypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets
Fritz K, Sanidas G, Cardenas R, Ghaemmaghami J, Byrd C, Simonti G, Valenzuela A, Valencia I, Delivoria-Papadopoulos M, Gallo V, Koutroulis I, Dean T, Kratimenos P. Hypercapnia Causes Injury of the Cerebral Cortex and Cognitive Deficits in Newborn Piglets. ENeuro 2024, 11: eneuro.0268-23.2023. PMID: 38233145, PMCID: PMC10913040, DOI: 10.1523/eneuro.0268-23.2023.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitCare unitCortical neuronsCerebral cortexCritically Ill NewbornsEnergy failureSevere lung injuryCortical neuronal injuryLong-term suppressionImpaired neurobehaviorExposure to hypercapniaNeurodevelopmental outcomesIll newbornsLung injuryLipid peroxidationElectroencephalogram frequencyNeuronal injuryPersistent dysregulationDeoxyribonucleic acid fragmentationAssociated with changesNewbornsEffect of HCHypercapniaProapoptotic signaling