Alfred Lee, MD, PhD
Professor of Medicine (Hematology)Cards
About
Research
Publications
2025
Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome
Butt A, Sharda A, Lee A, Knight J. Analytical Review: Neutrophil Extracellular Traps and Antiphospholipid syndrome. Transfusion Medicine Reviews 2025, 150909. PMID: 40783311, DOI: 10.1016/j.tmrv.2025.150909.Peer-Reviewed Original ResearchNeutrophil extracellular trapsAntiphospholipid syndromeAdenosine A2A receptorNegative regulatorP-selectin glycoprotein ligand-1Anti-NET antibodiesInduction of NETosisTranscription factor KLF2Regulation of NETosisAutoimmune prothrombotic disorderDecondensed chromatinDevelopment of thrombosisElevated NET levelsNeutrophil-mediated mechanismsGranule proteinsComplement system activationActivated Protein CObstetric complicationsAntiphospholipid antibodiesProthrombotic disordersNeutrophil-derived granule proteinsThrombotic eventsThrombotic riskClinical manifestationsAutoimmune disordersImplementation of a Novel Interdisciplinary Pharmacology Curriculum in a Hematology/Oncology Fellowship Program
Kwaramba T, Forman R, Shamilov R, Goldber S, Lee A, Srikumar T. Implementation of a Novel Interdisciplinary Pharmacology Curriculum in a Hematology/Oncology Fellowship Program. EMJ Oncology 2025, 2: 78-79. DOI: 10.33590/oncolamj/tcyd4672.Peer-Reviewed Original ResearchInternational Medical Graduates Representation at International Oncology Conference Meetings: An Analysis of ASCO Annual Meetings.
Roy A, Bakouny Z, Dizman N, Paul M, Ozay Z, Lal B, Nawfal R, Eid M, Chehade R, Machaalani M, Butt A, Aggarwal C, Bekaii-Saab T, Chavez-MacGregor M, Lopes G, Marshall A, Murphy M, Owonikoko T, Xie W, Lee A, Choueiri T. International Medical Graduates Representation at International Oncology Conference Meetings: An Analysis of ASCO Annual Meetings. JCO Oncology Practice 2025, op2500067. PMID: 40577682, DOI: 10.1200/op-25-00067.Peer-Reviewed Original ResearchInternational medical graduatesAmerican medical graduatesASCO Annual MeetingFaculty rolesMedical graduatesInternational oncology meetingsMultivariate analysis assessed factorsOncology workforceOncology meetingsUnited StatesUnder-recognitionInvited facultyPracticing oncologistsFellowship traineesASCOConference meetingsOriginal researchPresentationMeetingAnnual MeetingPresent dataFacultyGraduatesAcademic rankWorkforceImplementation of a novel interdisciplinary pharmacology curriculum in a hematology/oncology fellowship program.
Forman R, Kwaramba T, Shamilov R, Goldberg S, Lee A, Srikumar T. Implementation of a novel interdisciplinary pharmacology curriculum in a hematology/oncology fellowship program. Journal Of Clinical Oncology 2025, 43: 9028-9028. DOI: 10.1200/jco.2025.43.16_suppl.9028.Peer-Reviewed Original ResearchMechanism of actionCase-basedFellowship programsCancer-directed therapyDrug mechanism of actionTreatment decision makingDosing considerationsPharmacology curriculumToxicity managementTreatment optionsPatient counselingInterdisciplinary patient careLearning science principlesCancer therapeuticsPre-post designCase-based formatPost-lecture surveysThematic qualitative analysisActive learningDrug mechanismsCase-based approachDisease typePost-survey respondentsCase-based curriculumCareer transitions and practice patterns among international medical graduates in oncology workforce: A US nationwide analysis.
Xing J, Wang Q, Tang Y, Lu C, Chen F, Roy A, Deng L, Neupane K, Ardeshir Larijani F, Bekaii-Saab T, Aggarwal C, Lee A, Owonikoko T, Chavez Mac Gregor M, Bakouny Z, Gandhi S, Dizman N, Choueiri T, Perimbeti S, Jiang C. Career transitions and practice patterns among international medical graduates in oncology workforce: A US nationwide analysis. Journal Of Clinical Oncology 2025, 43: 9009-9009. DOI: 10.1200/jco.2025.43.16_suppl.9009.Peer-Reviewed Original ResearchInternational medical graduatesRural-Urban Continuum CodesCancer care deliveryOncology workforceMedical graduatesCare deliveryMedical oncologistsUS graduatesNCI-designated Cancer CentersDesignated cancer centersCross-sectional studyNon-metropolitan areasContinuum CodesWorkforce disparitiesUnderserved regionsSystemic barriersCareer stagesChi-square testPrimary specialtyPracticing medical oncologistsNCI centersStratified analysisAcademic affiliationPractice patternsPrimary outcomeBoard certification practices of US hematologists and oncologists.
Wesevich A, Schmitt L, Wesevich M, Lee A. Board certification practices of US hematologists and oncologists. Journal Of Clinical Oncology 2025, 43: 9034-9034. DOI: 10.1200/jco.2025.43.16_suppl.9034.Peer-Reviewed Original ResearchCenters for Medicare & Medicaid ServicesAmerican Board of Internal MedicineMaintenance of CertificationTeaching hospitalCareer pathwaysRural-Urban Commuting Area codesCertification practicesFemale genderMedical school graduatesSchool graduatesNon-teaching hospitalsMedicare Part BPhysician characteristicsArea codeMedicaid ServicesTrained physiciansNon-metropolitanInternal medicineOpen PaymentsCredentialing practicesMedical schoolsOncology boardUnited StatesFellowship programsMedical oncologistsAmerican Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary
Siegal D, Tseng E, Schünemann H, Angchaisuksiri P, Cuker A, Dane K, DeSancho M, Diuguid D, Griffin D, Klok F, Lee A, Neumann I, Pai A, Righini M, Sanfilippo K, Terrell D, Akl E, Al Jabiri R, Al Jabiri Y, Barbara A, Bognanni A, Akl I, Boulos M, Brignardello-Petersen R, Chan M, Charide R, Colunga-Lozano L, Dearness K, Darzi A, Hussein H, Karam S, Kolb P, Mansour R, Morgano G, Morsi R, Muti-Schünemann G, Nadim M, Noori A, Philip B, Piggott T, Qiu Y, Benitez Y, Schünemann F, Stevens A, Solo K, Wiercioch W, Mustafa R, Nieuwlaat R. American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary. Blood Advances 2025, 9: 1247-1260. PMID: 39437797, PMCID: PMC11950770, DOI: 10.1182/bloodadvances.2024014219.Peer-Reviewed Original ResearchConceptsCOVID-19-related critical illnessConditional recommendationAcute illnessHealth care professionalsAmerican Society of HematologyProphylactic-intensity anticoagulationCritical illnessEvidence-based recommendationsVenous thromboembolismRandomized Controlled TrialsCare professionalsPatient representativesRisk of venous thromboembolismGuideline developmentRecommendations AssessmentTherapeutic-intensity anticoagulationExecutive summaryLiving guidelinesMultidisciplinary panelIncreased risk of venous thromboembolismSystematic reviewAssessed certaintyCOVID-19-relatedControlled TrialsMcMaster UniversityInitial management of patients with acquired aplastic anemia in the United States: results from a large national claims database
Stempel J, Wang R, Lee A, Zeidan A, Ma X, Podoltsev N. Initial management of patients with acquired aplastic anemia in the United States: results from a large national claims database. Annals Of Hematology 2025, 104: 2507-2515. PMID: 40102305, PMCID: PMC12052795, DOI: 10.1007/s00277-025-06307-z.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAcquired Aplastic AnemiaCalcineurin inhibitorsParoxysmal nocturnal hemoglobinuriaTransfusion-DependentTriple therapyAA patientsAplastic anemiaAllogeneic hematopoietic stem cell transplantationTreated with calcineurin inhibitorsTreated with antithymocyte globulinFlow cytometryInitial management of patientsSevere AA patientsStem cell transplantationBone marrow failureImmune-mediated disordersTreatment initiation delayRetrospective cohort studyManagement of patientsDiagnosis to treatmentNational claims databaseAntithymocyte globulinSibling donorMarrow failureIntercontinental variations in the presentation and management of venous thromboembolism
Chaar C, Chan S, Lee A, Bikdeli B, Tiberio G, Chopard R, Weinberg I, Yamashita Y, Nikandish R, Monreal M. Intercontinental variations in the presentation and management of venous thromboembolism. JVS-Vascular Insights 2025, 3: 100201. DOI: 10.1016/j.jvsvi.2025.100201.Peer-Reviewed Original ResearchManagement of venous thromboembolismVenous thromboembolismPulmonary embolismLow-risk pulmonary embolismTreatment modalities of patientsOpen pulmonary embolectomyVenous thromboembolism presentationHigh-risk PEIntermediate-risk PELow-molecular-weight heparinLower body mass indexVitamin K antagonistsSystemic thrombolytic therapyProportion of patientsVenous thromboembolism patientsBody mass indexCoronary artery diseaseTreatment of PEPulmonary embolectomyK antagonistsOral anticoagulantsProximal DVTActive cancerOutpatient anticoagulationEndovascular treatment
2024
In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor
Restrepo-Espinosa V, Lee A, Prozora S, Patel P, Nassiri N. In-human clinical experience with direct stick embolization of low-flow vascular malformations using a mammalian target of rapamycin inhibitor. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2024, 13: 101997. PMID: 39515753, PMCID: PMC12014304, DOI: 10.1016/j.jvsv.2024.101997.Peer-Reviewed Original ResearchLow-flow vascular malformationsMTOR inhibitorsClinical successVascular malformationsSide effectsLocalized intravascular coagulopathyOral aphthous ulcersKlippel-Trenaunay syndromeLymphatic malformationsVenous malformationsRe-interventionDelayed complicationsNon-syndromicTechnical successAphthous ulcersIntravascular coagulopathyD-dimerEndovascular treatmentSystemic exposureAdjunctive therapySystemic toxicityFrequent bloodMalformationsSelf-limitingMTOR inhibition
Academic Achievements & Community Involvement
Clinical Care
Overview
Alfred Ian Lee, MD, PhD, is Professor of Medicine (Hematology) and Program Director for the hematology/oncology fellowship program. He received his MD/PhD from the Yale School of Medicine in 2004. Dr. Lee completed residency in internal medicine at Brigham & Women’s Hospital, where he served as Chief Medical Resident, followed by a fellowship in hematology/oncology at Dana-Farber Cancer Institute. His primary academic interests are classical hematology, thrombosis, and medical education.
He has received such honors as the Charles W. Bohmfalk Prize for teaching in the basic sciences, the Leah M. Lowenstein Award for excellence in the promotion of humane and egalitarian medical education, the Yale Cancer Center Award for Mentorship Excellence, and the David J. Lefell Prize for Clinical Excellence.
Clinical Specialties
Hematology; Hematology & Oncology
Fact Sheets
Hereditary Hemorrhagic Telangiectasia (HHT)
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News
- December 01, 2025
Yale Cancer Center Experts to Present Latest Findings at American Society of Hematology’s Annual Meeting
- February 06, 2025Source: Medscape
Compassion Fatigue: How Oncologists Can Recognize the Signs
- June 12, 2024
Yale Medical Oncology-Hematology Fellowship Graduation 2024
- May 28, 2024
Annual Fellows Research Day 2024
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