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George Goshua, MD, MSc, FACP

Assistant Professor of Medicine (Hematology)
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Appointments

Hematology
Primary

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About

Titles

Assistant Professor of Medicine (Hematology)

Biography

George Goshua, MD, MSc, FACP is an Assistant Professor of Medicine (Hematology-Oncology) in the Clinician-Scientist Track. He is a Yale-trained, board-certified internist and hematologist-oncologist, with methodological training in risk and decision science from the Harvard T.H. Chan School of Public Health. Dr. Goshua is the PI of the first quantitative decision analytic modeling laboratory in hematology-oncology in the United States (Goshua Lab), supported by the Yale Cancer Center, the NOMIS Foundation, Frederick A. DeLuca Foundation and the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI). His clinical expertise is in the care of adults with rare hematologic disorders, with a particular focus in immunohematology and thrombosis. His laboratory research employs quantitative decision analytic modeling methods to #1 fill gaps in clinical guidelines, #2 impact health resource allocation and/or #3 inform health policy decisions. This body of original science has been published in journals that include the Annals of Internal Medicine, Blood (inclusive of a #1 globally trending manuscript), The Lancet Haematology (the journal's #1 most cited original research), Med (Cell Press), The Lancet Regional Health, Blood Advances, American Journal of Hematology (2021 AJH Young Investigator Award, 2022 AJH YIA Finalist), Science Immunology, Chest, and Clinical Infectious Diseases. Beyond research recognitions awarded by the leading hematology societies, Dr. Goshua's invited service at the interface of decision science and clinical medicine includes the 1. American Society of Hematology Patient Decision Aid Steering Group, 2. Institute for Clinical and Economic Review's Independent Appraisal Committee, and 3. Editorial Board at the Annals of Internal Medicine, with an expert focus in health economics.

Appointments

  • Hematology

    Assistant Professor
    Primary

Other Departments & Organizations

Education & Training

MSc
Harvard T.H. Chan School of Public Health, Risk and Decision Science (Department of Health Policy & Management) (2022)
Clinical Fellow (Hematology-Oncology)
Yale School of Medicine (2022)
Instructor of Medicine and Chief Medical Resident
Yale School of Medicine (2019)
Resident
Yale School of Medicine (2018)
MD
University of Kentucky College of Medicine (2015)
BSc (Hon)
University of Toronto, Neuroscience & Physiology Double Major, Forest Conservation Minor (2010)

Research

Overview

As in 2017, in 2021 the United States again ranked #11/11 both on overall performance and across several domains of health care system performance in The Commonwealth Fund's reports "Mirror, Mirror 2017"and "Mirror, Mirror 2021". These rankings are despite the known, decades-long breakaway #1 global ranking in healthcare spending as percentage of GDP. Our consistent #11/11 rankings in the domains of Access (i.e., affordability and timeliness), Equity (i.e., difference between low- and high-income individuals), and Healthcare Outcomes (i.e., population health, mortality amenable to health care, disease-specific health outcomes) are particularly amenable to resource allocation optimization. That is, delivering affordable and equitable care at the right time to the right individuals. Decision analytic modeling allows an explicit quantification of effect estimates, precision intervals and uncertainty present in any given medical decision where tradeoffs are present. The United States' clinical hematologic-oncologic space is particularly rife with new, expensive therapeutic offerings, many times with unclear effect on quality-of-life, and this is where our laboratory fuses methodologic and clinical expertise.

For practical impact of, and research accolades for, our lab's work please visit us at www.goshualab.com. Briefly for the former, this has included 1. inpatient formulary approval of rituximab for patients with immune thrombotic thrombocytopenic purpura (iTTP) in the US hospital setting, 2. clinical optimization of tocilizumab in a supply-limited context in Canada, 3. international debate as to the efficacy, safety, and consequent cost-ineffectiveness of caplacizumab in iTTP, 4. gap fill in the American Society of Hematology guidelines for optimal second-line treatment sequencing for patients with chronic immune thrombocytopenia, 5. quantitative accounting of health equity consideration for the first time in hematology oncology (in gene therapy for patients with sickle cell disease). Ongoing and planned work includes research in alloimmunization, gene therapy, maternal-fetal hematology, complement inhibition, iron deficiency, iron chelation, thrombosis, with a particular focus on the quantitative modeling of health equity considerations in all of these diseases within the United States.

Medical Research Interests

Clinical Decision Rules; Clinical Decision-Making; Decision Trees; Health Care Costs; Health Equity; Hematology; Low-Value Care; Markov Chains; Quality of Life; Survival Analysis

Research at a Glance

Yale Co-Authors

Frequent collaborators of George Goshua's published research.

Publications

Featured Publications

Academic Achievements & Community Involvement

  • honor

    Top Reviewer [2023 Calendar Year]

  • honor

    NOMIS & Science Young Explorer Award

  • honor

    Top Reviewer [2022 Calendar Year]

  • honor

    2022 Young Investigator Award [Finalist]

  • honor

    2021 Young Investigator Award

Clinical Care

Overview

George Goshua, MD, MSc, FACP, is a physician-scientist who specializes in hematology, diagnosing and treating various blood disorders, such as thrombosis and anemia.

Dr. Goshua runs the first health decision science laboratory focused on hematology-oncology outcomes in the United States. His research has been repeatedly awarded by the leading hematology societies, the NOMIS Foundation, and Science Magazine.

Dr. Goshua is an assistant professor of medicine at Yale School of Medicine.

Clinical Specialties

Hematology

Board Certifications

  • Hematology (Internal Medicine)

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    2022
  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    2018