Alexander B. Pine, MD, PhD
Assistant Professor of Medicine (Hematology)DownloadHi-Res Photo
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Assistant Professor of Medicine, Hematology
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Assistant Professor of Medicine, Hematology
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Assistant Professor of Medicine, Hematology
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About
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Titles
Assistant Professor of Medicine (Hematology)
Assistant Professor of Medicine, Hematology
Biography
Last Updated on November 02, 2023.
Appointments
Medical Oncology and Hematology
Assistant ProfessorPrimary
Other Departments & Organizations
- Creed House Affiliates
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
- Yale Cancer Center
- Yale Medicine
Education & Training
- Clinical Fellow (Hematology/Oncology)
- Yale School of Medicine (2020)
- MD
- Case Western Reserve University School of Medicine (2012)
- PhD
- Drexel University (2002)
Research
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Overview
Medical Research Interests
Antiphospholipid Syndrome; Blood Coagulation Disorders; Hematology
ORCID
0000-0002-9463-3022
Research at a Glance
Yale Co-Authors
Frequent collaborators of Alexander B. Pine's published research.
Publications Timeline
A big-picture view of Alexander B. Pine's research output by year.
Research Interests
Research topics Alexander B. Pine is interested in exploring.
Alfred Lee, MD, PhD
Amer Zeidan, MBBS, MD
Ayesha Butt, MBBS
Hanming Zhang, PhD
John Hwa, MD, PhD, FRACP
Christopher Tormey, MD
24Publications
2,225Citations
Blood Coagulation Disorders
Antiphospholipid Syndrome
Publications
2026
Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolaccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. Correction: A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2026, 17: 1807468. DOI: 10.3389/fimmu.2026.1807468.Commentaries, Editorials and Letters
2025
A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry
Pine A, Butt A, Andreoli L, Knight J, Gerosa M, Cecchi I, Branch D, Lopez-Pedrera R, Belmont H, Kello N, Petri M, Cervera R, Pengo V, Meroni P, Cohen H, Willis R, Bertolccini M, Goshua G, Gu S, Hwa J, Lee A, Erkan D, Sharda A. A proteomic map of thromboinflammatory signatures in antiphospholipid syndrome: results from antiphospholipid syndrome alliance for clinical trials and international networking (APS ACTION) registry. Frontiers In Immunology 2025, 16: 1676578. PMID: 41181143, PMCID: PMC12571811, DOI: 10.3389/fimmu.2025.1676578.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntiphospholipid syndromeInflammatory signatureClinical trialsAdaptive immune response pathwaysPersistently aPL-positive patientsPathogenesis of antiphospholipid syndromeClinical antiphospholipid syndromePathophysiology of antiphospholipid syndromeAPL-positive patientsCirculating antiphospholipid antibodiesPresence of aPLAntiphospholipid syndrome classificationAdaptive immune activationActivation of coagulationStatistical significanceAntiPhospholipid Syndrome AllianceMultiple pathophysiological mechanismsObstetric morbidityAntiphospholipid antibodiesImmune response pathwaysImmune cellsImmune activationAutoimmune diseasesProteomic screenClinical severity
2024
Cancer-Associated Venous Thromboembolic Disease, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Streiff M, Holmstrom B, Angelini D, Ashrani A, Buckner T, Diep R, Fertrin K, Fogerty A, Crestani N, Gangaraju R, Rojas-Hernandez C, Goldhaber S, Ibrahim I, Kubal T, Leavitt A, Lim M, Mann J, Mantha S, Morton C, Nester A, O'Brien A, Ortel T, Pine A, Pishko A, Ranade M, Salmasi A, Schaefer J, Williams E, Wool G, Wun T, Montgomery S, Nguyen J, Freedman-Cass D, Sliker B. Cancer-Associated Venous Thromboembolic Disease, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2024, 22: 483-506. PMID: 39236759, DOI: 10.6004/jnccn.2024.0046.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsNCCN Clinical Practice GuidelinesNCCN guidelinesClinical practice guidelinesVenous thromboembolismVenous thromboembolic diseaseNCCN panelCancer-associated venous thromboembolismInternal medicinePractice guidelinesMedical oncologyThromboembolic diseaseTreatment of venous thromboembolismNCCNLife-threatening conditionMultidisciplinary effortRecommended treatment optionGuidelinesOncologyAdult patientsTreatment optionsInterventional radiologyDiverse subtypesCancerPatientsPreventionFactor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease
Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 148: 220-225. PMID: 39004080, PMCID: PMC12106121, DOI: 10.1159/000540239.Peer-Reviewed Original ResearchCitationsConceptsISTH DIC scoreFactor VIII levelsArea under the curveDIC scoreLiver diseaseFactor VIIIRetrospective chart review of patientsChart review of patientsCoagulopathy of liver diseaseReview of patientsRetrospective chart reviewCalculate area under the curveReceiver operating characteristic curveMultiple logistic regressionISTH scoreLaboratory parametersClinical challengeClinical utilityPatientsCharacteristic curveLab variablesLogistic regressionLiverDiseaseDiagnostic tool
2023
Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome
Allen C, Gautam S, Cheng W, Pine A, Podoltsev N, Zeidan A, Lee A, Shallis R. Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome. Acta Haematologica 2023, 146: 287-292. PMID: 37166332, PMCID: PMC12106122, DOI: 10.1159/000530153.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAML/myelodysplastic syndromeAcute myeloid leukemiaInternational normalized ratioAntibacterial prophylaxisMyelodysplastic syndromeProphylactic antibacterialsCoagulation profileAcute myeloid leukemia/myelodysplastic syndromeDiagnosis of AMLHigher international normalized ratioLeukemia/myelodysplastic syndromePartial thromboplastin time prolongationYale-New Haven HospitalYale-New HavenRetrospective cohort studyAbnormal coagulation profileGroup of patientsTime of admissionHigh rateIndividual patient encountersInstitutional review boardAntibacterial exposureRelevant bleedingAdult patientsCohort study
2022
Association of iron infusion reactions with ABO blood type
Butt A, Muradashvili T, Soliman S, Li F, Burns AJ, Brooks A, Browning S, Bar N, Borgman G, Goshua G, Hwa J, Martin K, Rinder H, Tormey C, Pine AB, Bona RD, Lee AI, Neparidze N. Association of iron infusion reactions with ABO blood type. European Journal Of Haematology 2022, 109: 519-525. PMID: 35871468, DOI: 10.1111/ejh.13838.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGreater oddsBlood typeYale Cancer CenterInfusion-related reactionsRetrospective chart reviewLarger patient numbersABO blood typeType AB bloodChart reviewInfusion reactionsMost patientsHematology clinicIron sucroseMultivariable analysisProspective studyCancer CenterPatient numbersIron dextranRisk factorsIron infusionIron repletionPatientsPossible associationAB bloodBlood
2021
Challenges in interpreting cytokine data in COVID-19 affect patient care and management
Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsImmuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2
Chun HJ, Coutavas E, Pine AB, Lee AI, Yu VL, Shallow MK, Giovacchini CX, Mathews AM, Stephenson B, Que LG, Lee PJ, Kraft BD. Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2. JCI Insight 2021, 6: e148476. PMID: 34111030, PMCID: PMC8410030, DOI: 10.1172/jci.insight.148476.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 severityIntensive care unitCOVID-19 illnessRespiratory symptomsLipocalin-2Acute COVID-19 illnessSARS-CoV-2 infectionCOVID-19Acute COVID-19Mild COVID-19Prospective cohort studyPulmonary function testsPost-acute sequelaeAmerican Heart AssociationHost response profileSeparate validation cohortAcademic medical centerSARS-CoV-2Plasma biomarker profilesICU groupLung recoveryCohort studyExpiratory volumeLung impairmentPersistent symptomsLiver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLiver sinusoidal endothelial cellsLiver injuryInterleukin-6Sinusoidal endothelial cellsAlanine aminotransferaseLiver histologyD-dimerCOVID-19Primary human liver sinusoidal endothelial cellsSARS-CoV-2 infectionHuman liver sinusoidal endothelial cellsEndothelial cellsSoluble glycoprotein 130IL-6 levelsSmall-interfering RNA knockdownJAK inhibitor ruxolitinibFactor VIII activityProinflammatory factorsInflammatory signalsLarge cohortInhibitor ruxolitinibVWF antigenEndotheliopathyPatientsInjuryIncreased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Ma L, Sahu S, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish M, Goshua G, Chang C, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo A, Goss C, O’Halloran J, Presti R, Kim A, Gelman A, Dela Cruz C, Lee A, Mudd P, Chun H, Atkinson J, Kulkarni H. Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection. Science Immunology 2021, 6: eabh2259. PMID: 34446527, PMCID: PMC8158979, DOI: 10.1126/sciimmunol.abh2259.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSevere SARS-CoV-2 infectionSARS-CoV-2 infectionIntensive care unitComplement activationRespiratory failureEndothelial injuryCOVID-19Non-COVID cohortPersonalized clinical trialsAcute respiratory failureInvasive mechanical ventilationSevere COVID-19Tertiary care centerAlternative complement pathwayICU admissionCritical illnessCare unitMechanical ventilationRisk prognosticationWashington University SchoolWorse outcomesCare centerClinical trialsHigh riskPatients
Academic Achievements & Community Involvement
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Activities
activity American Society of Hematology
2017 - PresentProfessional OrganizationsMemberactivity National Comprehensive Cancer Network
2022 - PresentProfessional OrganizationsCommittee MemberDetailsDr. Pine is a member of NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease Panelactivity Proteomics of Antiphospholipid Syndromes
11/17/2023 - 11/17/2023Oral PresentationAntiphospholipid syndrome Alliance for Clinical Trials and International Networking (APS ACTION) 14th Annual Virtual SummitDetailsHeld virtuallyactivity Plasma Proteomic Profiling in Antiphospholipid Antibody-positive Patients with Different Clinical Phenotypes: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry
11/13/2023 - 11/13/2023Oral Presentation American College of RheumatologyDetailsSan Diego, CA, United StatesCollaboratorsactivity COVID-19 and Antiphospholipid Syndrome
05/10/2023 - 05/10/2023LectureYale Rheumatology Grand RoundsDetailsNew Haven, CT, United States
Honors
honor Hematology and Medical Oncology Fellowship Program Annual Research Award
06/30/2020Yale School of Medicine AwardYale Cancer CenterDetailsUnited States
Teaching & Mentoring
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Mentoring
Valentina Restrepo-Espinosa, MD
Postdoc2023 - PresentTariq Kewan, MD
hematology oncology fellow2023 - PresentCecily Allen, MD
Internal medical resident2021 - 2023Daria Madeeva, MD
Internal medicine resident2020 - 2022
Clinical Care
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Overview
Alexander B. Pine, MD, PhD, is a hematologist specializing in blood clotting disorders and antiphospholipid syndrome, an autoimmune disorder where the body produces antibodies that make the blood more likely to clot, leading to an increased risk of blood clots, miscarriages, and other complications. He provides comprehensive care to patients with these conditions, using various approaches to manage and treat blood-related health issues.
As an assistant professor of medicine at Yale School of Medicine, Dr. Pine is involved in research focused on understanding blood coagulation disorders and their impact on health. He completed his medical training at Case Western Reserve University School of Medicine, followed by an internship and residency at Yale New Haven Hospital. Dr. Pine further specialized with a clinical fellowship in hematology and oncology at Yale School of Medicine.
Clinical Specialties
Internal Medicine; Hematology
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