Georges El Fakhri, PhD, DABR
Elizabeth Mears and House Jameson Professor of Radiology and Biomedical Imaging, Therapeutic Radiology and of Biomedical Informatics & Data ScienceCards
About
Research
Publications
2025
Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET
Zeng T, Najmaoui Y, Zhang J, Fontaine K, Hu Y, Chemli Y, Gallezot J, Sun C, Lu Y, Fakhri G, Carson R, Marin T. Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287015.Peer-Reviewed Original ResearchSpatially-varying point spread functionPoint spread functionAccurate point spread functionPSF modelConvergence behaviorImage qualityPoint spread function modelReconstruction toolboxPSF parametersHigh-activity regionsBrain-dedicated PET scannersDepth of interactionPoint-spread-function modelingField of viewSpatial resolutionHuman scansContrast recoverySpread functionPET systemPET scannerReal phantomBrain phantomMonte Carlo simulationsBrain positron emission tomographyCarlo simulationsPhysics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET
Chemli Y, Najmaoui Y, Normandin M, Fakhri G, Marin T, Ouyang J. Physics-Informed List-Mode Deep Image Prior Reconstruction with Motion Correction in 3D Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287851.Peer-Reviewed Original ResearchDeep Image PriorList-modeContrast recoveryMotion correctionList-mode eventsReconstructed activity distributionHoffman brain phantomNoise-resolution trade-offML-EM reconstructionLow-count dataResolution phantomBrain phantomBrain positron emission tomographySuper-resolution effectActivity distributionModel attenuationML-EMBack-projection operationsFine structureDown-sampled dataNegative log-likelihoodImage registrationUnsupervised regularizerBack-projectionImage priorsPerformance Evaluation of FastIC+ for sub-100 ps TOF-PET Module Development
Mazzanti D, Gomez S, Mauricio J, Alozy J, Auffray E, Bandi F, Campbell M, Cardona C, Dolenec R, Fakhri G, Fernandez-Tenllado J, Gola A, Guberman D, Lowis C, Majewski S, Manera R, Mariscal-Castilla A, Penna M, Pestotnik R, Paterno A, Portero S, Sanuy A, Silva J, Terragni G, Ballabriga R, Gascon D. Performance Evaluation of FastIC+ for sub-100 ps TOF-PET Module Development. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287230.Peer-Reviewed Original ResearchCoincidence time resolutionLYSO:CeTime-of-flight positron emission tomographyDouble-sided readoutTOF-PET applicationDepth of interactionApplication-specific integrated circuitTOF-PETCorrect parallax errorsSilicon photomultipliersDetector arrayTime-of-flightParallax errorCrystal arrayTime resolutionLong crystalsReference crystalLYSOFWHMPerformance evaluationPower consumptionCrystalIntegrated CircuitsCa crystalsScintillationImpact of TOF Resolution on Required Angular Coverage in PET: a Monte Carlo Study
Razdevsek G, Dolenec R, Orehar M, Fakhri G, Majewski S, Pestotnik R. Impact of TOF Resolution on Required Angular Coverage in PET: a Monte Carlo Study. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-1. DOI: 10.1109/nss/mic/rtsd57106.2025.11287018.Peer-Reviewed Original ResearchTime-of-flight resolutionTime-of-flightArtifact-free reconstructionAngular coverageNEMA image quality phantomAngular sampling requirementsTime-of-flight informationInter-crystal scatterImage quality phantomDepth of interactionOpen geometrySystematic Monte Carlo simulationsDerenzo phantomTOF resolutionImage qualityPET scannerMonte Carlo simulationsElongation artifactsPoint sourcesMonte Carlo studyCarlo simulationsLesion contrastSpatial resolutionImage noiseSystem geometryO119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY.
Depauw N, Bijari F, Garonna A, Kang J, Chemli Y, Deng H, Dhaynaut M, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian M, Fakhri G, Levine R, Lehmann H, Chen Y, Jee K. O119 / #388 EVALUATION OF CARDIO-RESPIRATORY-GATING FOR PROTON CARDIAC ABLATION: A LARGE-ANIMAL STUDY. International Journal Of Particle Therapy 2025, 17: 100875. DOI: 10.1016/j.ijpt.2025.100875.Peer-Reviewed Original ResearchNuclear Medicine AI in Action: The Bethesda Report (AI Summit 2024).
Rahmim A, Bradshaw T, Davidzon G, Dutta J, El Fakhri G, Ghesani M, Karakatsanis N, Li Q, Liu C, Roncali E, Saboury B, Yusufaly T, Jha A. Nuclear Medicine AI in Action: The Bethesda Report (AI Summit 2024). Journal Of Nuclear Medicine 2025, jnumed.125.269540. PMID: 41290370, DOI: 10.2967/jnumed.125.269540.Peer-Reviewed Original ResearchMulticenter PET Image Harmonization Using Style-Guided CycleGAN in Primary Central Nervous System Lymphoma : InStyleGAN
Arzur D, Marin T, Horowitz T, Kas A, El Fakhri G, Mhiri I, Rozenblum L. Multicenter PET Image Harmonization Using Style-Guided CycleGAN in Primary Central Nervous System Lymphoma : InStyleGAN. Lecture Notes In Computer Science 2025, 16164: 126-138. DOI: 10.1007/978-3-032-07904-6_12.Peer-Reviewed Original ResearchRobust deep learning modelAdaptive instance normalizationTarget modalityDeep learning modelsInstance NormalizationDistribution alignmentDomain shiftImage harmonizationModel generalizationLatent domainsLearning modelsComputational costNon-scalableCycleGANImage dataData pairsPrimary central nervous system lymphomaAcquisition settingsFrameworkCentral nervous system lymphomaPET dataDomainDataNervous system lymphomaHarmonized frameworkCentral Nervous System Biodistribution and Pharmacokinetics of Radiolabeled Tofersen in Rodents, Nonhuman Primates, and Humans.
Cook B, McLaren D, Sullivan J, El Fakhri G, Yokell D, Freeman M, Currier N, Oestergaard M, Dobson H, Hesterman J, Salem N, Nestorov I, Monine M, Martarello L, Evans K, Fradette S, Ferguson T, Graham D, Passamonti L. Central Nervous System Biodistribution and Pharmacokinetics of Radiolabeled Tofersen in Rodents, Nonhuman Primates, and Humans. Journal Of Nuclear Medicine 2025, jnumed.125.270731. PMID: 41233143, DOI: 10.2967/jnumed.125.270731.Peer-Reviewed Original ResearchSpinal cordAntisense oligonucleotidesNonhuman primatesBrain uptakeClinical effectsCentral nervous system biodistributionConclusion:Potential future treatment optionsRegional brain uptakeFuture treatment optionsTreatment of amyotrophic lateral sclerosisSOD1 geneHealthy human volunteersHuman dosimetry estimatesRadiation dose levelsSPECT/CT studiesSPECT/CT imagingSystemic biodistributionTofersenLumbar punctureLumbar spineBrain concentrationsDosimetry estimatesPreclinical studiesTherapeutic dosesYRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER
Najmaoui Y, Fontaine K, Fontaine D, Zhang J, Zeng T, Volpi T, Chemli Y, Gallezot J, Tétrault M, Carson R, Fakhri G, Marin T. YRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER. 2025, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287275.Peer-Reviewed Original ResearchOpen-sourcePeak-to-valley ratioMini-Derenzo phantomReconstruction platformResolution PET scannerImage reconstruction toolsPacket decodingDetector geometryGPU accelerationMemory usagePET scannerPET systemAccurate system modelMotion correctionScatter estimationVendor softwareReconstruction timeImage reconstructionPluginImage qualitySoftwareHuman datasetsSystem modelManufacturing softwareNon-human primatesLR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization
Djebra Y, Najmaoui Y, Chemli Y, Normandin M, Fakhri G, Ma C, Marin T. LR-PET: A Subspace-Based Dynamic PET Imaging via Explicit Non-Negative Low-Rank Factorization. 2025, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57106.2025.11286709.Peer-Reviewed Original Research
News
News
- November 10, 2025
NETS Awareness Day 2025
- June 16, 2025
Yale Announces New Biomedical Imaging Institute
- March 05, 2025
PET mapping of receptor occupancy using joint direct parametric reconstruction
- March 03, 2025
Trainee Zhen Li awarded at SPIE Medical Imaging 2025
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Radiology & Biomedical Imaging
330 Cedar ST, P.O. Box 208042
New Haven, CT 06520
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Jan 202626Monday
Yale Only Georges El Fakhri, PhD, DABR