Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSuhas Ganesh
Assistant Professor (Adjunct) of PsychiatryAbout
Research
Publications
2026
Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure.
D’Souza D, Cortes-Briones J, Raj J, Ganesh S, Vidya K, Krishna Tikka S, Shreekantiah U, Singh N, Murthy P, Urrutia-Gandolfo J, Ram D, Sharma P, Sinha V, Goyal N. Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure. American Journal Of Psychiatry 2026, appiajp20250726. PMID: 42231079, DOI: 10.1176/appi.ajp.20250726.Peer-Reviewed Original ResearchFirst-episode psychosisCannabis exposureMood symptomsCannabis useBehavioral presentationAbsence of group differencesPresentation of first-episode psychosisCortical E/I balanceCognitive test performanceRates of psychosisStandard inpatient treatmentNew-onset psychosisNegative symptomsPsychosis exacerbationPsychosis symptomsIllness courseAssociated with relapseIllness recurrencePsychosisCognitive testsCognitive functionSymptom ScaleE/I balanceGroup differencesInpatient treatment52. Neurodevelopment Dysregulation Underlies Pathogenesis of Bipolar Disorder
Paul P, Udupa M, Lakshana D, Vishnu V, Mythri S, Anand L, Almas M, Varshini A, Ravikumar K, Bindu K, Ashitha S, Phalnikar K, Sukumaran S, Ganesh S, Guttal V, Muralidharan B, Purushottam M, Jain S, Sud R, Viswanath B. 52. Neurodevelopment Dysregulation Underlies Pathogenesis of Bipolar Disorder. Biological Psychiatry 2026, 99: s97-s98. DOI: 10.1016/j.biopsych.2026.03.232.Peer-Reviewed Original Research
2024
A Novel Homozygous Variant in CPLANE1 Gene in a Patient with Developmental Deficits
Shankarappa B, Prasad V, Kumar S, Rao R, Royal A, Swamy M, Prasad P, Murthy A, Ganesh S, Viswanath B, Jain S, Purushottam M, Thyloth M. A Novel Homozygous Variant in CPLANE1 Gene in a Patient with Developmental Deficits. Molecular Syndromology 2024, 16: 87-92. PMID: 39911166, PMCID: PMC11793906, DOI: 10.1159/000541167.Peer-Reviewed Original ResearchOral-facial-digital syndromeOrofacial anomaliesRare syndromeJoubert syndromeOral-facial-digital syndrome type 1Features of Joubert syndromeClinical exome sequencingWild-type alleleRural community clinicsStructural chromosomal abnormalitiesSubstitution of glycineMild developmental delayX-linked dominant inheritanceAutosomal recessive inheritanceMutation databaseChromosomal microarrayDevelopmental deficitsExome sequencingGenetic analysisOrofacial featuresRare subtypeSanger sequencingChromosomal abnormalitiesExon 5Gene c.Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder
Phalnikar K, Srividya M, Mythri S, Vasavi N, Ganguly A, Kumar A, S P, Kalia K, Mishra S, Dhanya S, Paul P, Holla B, Ganesh S, Reddy P, Sud R, Viswanath B, Muralidharan B. Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder. Oxford Open Neuroscience 2024, 3: kvae007. PMID: 38638145, PMCID: PMC11024480, DOI: 10.1093/oons/kvae007.Peer-Reviewed Original ResearchPatient organoidsNeural stem cellsBipolar disorderStem cellsTranscriptome analysis of controlPatient-derived organoidsFamilial bipolar disorderMigration defectsNeural stem cell culturesDysregulation of genesFamilial BDBD patientsCausative genetic variantsSox2-positiveNeurodevelopmental aberrationsNeurodevelopmental anomaliesIPSC-derived cerebral organoidsProgenitor proliferationStem cell culturesAbnormal positionPatientsNeuronal migrationCortical organoidsMolecular deficitsCycling progenitorsHybrid Tele-cognitive Behavioural Therapy (Ht-CBT) for Obsessive-compulsive Disorder: An Innovation Integrating In-person and Online Psychotherapy
Ganesh S, Sharma L, Das B. Hybrid Tele-cognitive Behavioural Therapy (Ht-CBT) for Obsessive-compulsive Disorder: An Innovation Integrating In-person and Online Psychotherapy. Indian Journal Of Psychological Medicine 2024, 46: 276-278. PMID: 38699761, PMCID: PMC11062316, DOI: 10.1177/02537176231219768.Peer-Reviewed Original ResearchPsychopharmacological Treatment of Schizophrenia
Singh N, Ganesh S, D'Souza D. Psychopharmacological Treatment of Schizophrenia. 2024, 729-737. DOI: 10.1016/b978-0-323-95702-1.00177-9.BooksAntipsychotic drugsPositive symptoms of schizophreniaPharmacological treatment of schizophreniaTreatment-resistant schizophreniaPharmacological treatmentSymptoms of schizophreniaTreatment of schizophreniaAcute psychotic episodeNeuroleptic malignant syndromeNegative symptomsPositive symptomsExtrapyramidal symptomsPsychotic episodeCognitive deficitsCognitive symptomsMalignant syndromeSchizophreniaPrevent relapseSide effectsMaintenance treatmentLong-actingDopamineAssociated with significant side effectsMedication adherenceProportion of patients
2023
The Acute Effects of Cannabinoids in Patients with Psychotic Illness
Ganesh S, Henquet C, Sewell R, Kuepper R, Ranganathan M, D’Souza D. The Acute Effects of Cannabinoids in Patients with Psychotic Illness. 2023, 225-239. DOI: 10.1017/9781108943246.023.Peer-Reviewed Original ResearchMental illnessMental health teamsHealth policy implicationsHigh-potency cannabisStages of neurodevelopmentPotential adverse effectsAcute effectsHealth teamsPsychotic illnessImpact of exposureCannabis dependenceAdverse effectsIllnessCannabisCannabinoidsSynthetic cannabinoidsPsychosisNew research findingsAssociationComplex associationPatientsNeurodevelopmentPutative modelSchizophreniaPeripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles
Ganesh S, Lam T, Garcia-Milian R, D'Souza D, Nairn A, Elgert K, Eitan E, Ranganathan M. Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles. The World Journal Of Biological Psychiatry 2023, 24: 603-613. PMID: 36994633, PMCID: PMC10471733, DOI: 10.1080/15622975.2023.2197039.Peer-Reviewed Original ResearchConceptsNeuron-derived extracellular vesiclesLabel-free quantification mass spectrometryProteomic studiesCannabis use disorderExtracellular vesiclesMass spectrometry proteomic analysisDifferential proteomic profilesAdapter proteinProteomic analysisPost-synaptic densityPeripheral signatureMolecular basisProteomic profilesProteinMarkers of neuropathologyBrain tissue samplesSynaptic pathologyVesiclesSynaptic integrityImmunoaffinity methodUse disordersFunctional integrityImportant insightsNeuropathologyPilot study
2022
Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
Ganesh S, Vemula A, Bhattacharjee S, Mathew K, Ithal D, Navin K, Nadella R, Viswanath B, Sullivan P, Jain S, Purushottam M. Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes. Scientific Reports 2022, 12: 21128. PMID: 36476812, PMCID: PMC9729597, DOI: 10.1038/s41598-022-25664-7.Peer-Reviewed Original ResearchConceptsSequence kernel association testKernel association testWhole-exome sequencing studiesExome sequencing studiesUnique genesGenetic architectureCase-control association analysisDeleterious variantsSequencing studiesWhole-exome sequencingMendelian syndromesAssociation analysisCriteria of rarityPleiotropic influenceGenesWES studyFunctional consequencesSignificant overrepresentationGenetic pleiotropyExome sequencingAffected individualsFamilyImportant insightsUnrelated controlsAssociation Test
2020
Association of SLC1A1 Gene Polymorphism With Obsessive Compulsive Disorder in a Sample From Southern India
Shukla T, Nadella R, J. R, Ganesh S, Nestadt G, Purushottam M, Jain S, Reddy Y, Viswanath B. Association of SLC1A1 Gene Polymorphism With Obsessive Compulsive Disorder in a Sample From Southern India. Experimental And Clinical Psychopharmacology 2020, 28: 617-621. PMID: 31985241, DOI: 10.1037/pha0000348.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment responseAge of onsetSRI treatment responseSignificant associationClinical parametersMini International Neuropsychiatric InterviewGenotype/allele frequenciesSymptom dimensionsSpecialty OCD clinicAdequate trialFull respondersNeuropsychiatric InterviewHealthy controlsBrain volumeGene polymorphismsOCD clinicDisease severityCase-control association analysisSymptom severityOCD patientsOCD casesGenotype frequenciesCompulsive disorderAssociation