Yun Liang, PhD, DABR
Assistant Professor of Therapeutic RadiologyAbout
Research
Publications
2025
Preoperative Fractionated Stereotactic Radiosurgery for Brain Metastases: A Prospective Pilot Study at a Single Institution
Marwaha A, Shepard M, Liang Y, Yu A, Karlovits S, Wegner R. Preoperative Fractionated Stereotactic Radiosurgery for Brain Metastases: A Prospective Pilot Study at a Single Institution. Advances In Radiation Oncology 2025, 11: 101951. PMID: 41503286, PMCID: PMC12768855, DOI: 10.1016/j.adro.2025.101951.Peer-Reviewed Original ResearchWhole-brain radiation therapyRates of local controlDistant brain failurePreoperative stereotactic radiosurgeryStereotactic radiosurgeryLeptomeningeal diseaseSurgical resectionProspective pilot studyFollow-upGamma KnifeBrain metastasesLocal controlOverall survivalPostoperative MRIRates of distant brain failureRates of leptomeningeal diseaseRisk of leptomeningeal diseaseNon-small cell lung cancerRisk of local recurrencePredictor of overall survivalBrain failureFractionated stereotactic radiosurgeryLocal control rateMedian prescription dosePhase 2 protocol
2024
Patterns of failure after stereotactic radiosurgery for brain metastases from small cell lung cancer: outcomes in the immunotherapy era
Marwaha A, Liang Y, Shepard M, Yu A, Karlovits S, Wegner R. Patterns of failure after stereotactic radiosurgery for brain metastases from small cell lung cancer: outcomes in the immunotherapy era. Journal Of Neuro-Oncology 2024, 172: 177-183. PMID: 39643852, DOI: 10.1007/s11060-024-04895-w.Peer-Reviewed Original ResearchConceptsMonths local controlStereotactic radiosurgeryCell lung cancerBrain metastasesDistant failureImmunotherapy eraMedian doseExtracranial diseaseOverall survivalBrain failureBrain metastases treated with stereotactic radiosurgeryLung cancerMedian numberPatients treated with stereotactic radiosurgeryMedian dose of radiationRate of distant failureRisk of distant failureDevelopment of brain metastasesLocal control of diseasePredictor of local failureSmall cell lung cancerDistant brain failureDistant failure ratesMedian overall survivalType of immunotherapyRadiation-Induced Cognitive Decline: Challenges and Solutions
Shamsesfandabadi P, Patel A, Liang Y, Shepard M, Wegner R. Radiation-Induced Cognitive Decline: Challenges and Solutions. Cancer Management And Research 2024, 16: 1043-1052. PMID: 39183756, PMCID: PMC11345022, DOI: 10.2147/cmar.s441360.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRadiation-induced cognitive declineMagnetic resonance imagingHigh-risk patientsTargeting of cancer cellsStem cell therapyCentral nervous system cancerMechanism of injuryCognitive functionAdvanced imaging techniquesRadiation therapyNervous system cancersVulnerable brain areasProton therapyCell therapyEmergency therapySystem cancersAdvanced ageCancer cellsPre-existing conditionsTherapyMultidisciplinary care teamResonance imagingNeuroprotective agentsWhite matterBrain white matterCost of Treatment for Brain Metastases Using Data From a National Health Insurance
Crooks J, Dominic O, Shepard M, Yu A, Liang Y, Karlovits S, Wegner R. Cost of Treatment for Brain Metastases Using Data From a National Health Insurance. Advances In Radiation Oncology 2024, 9: 101438. PMID: 38567144, PMCID: PMC10985802, DOI: 10.1016/j.adro.2024.101438.Peer-Reviewed Original ResearchWhole-brain radiation therapyIntensity modulated radiation therapyStereotactic radiation therapyBrain metastasesStereotactic radiosurgeryRadiation therapyGamma Knife stereotactic radiosurgeryLinear accelerator SRSLinear accelerator stereotactic radiosurgeryRadiation techniquesTreated with radiationSignificant health care challengeTumor controlGamma KnifeHealth care insuranceRadiation modalitiesCost of treatmentSide effectsTherapyInsurance claims dataHealth insurance patientsPhysician componentClaims codesMetastasisCare insurance
2023
The 5-factor modified frailty index as a prognostic factor of stereotactic radiosurgery for metastatic disease to the brain.
Lucido T, Rajkumar S, Rogowski B, Meinert J, Elhamdani S, Liang Y, Karlovits S, Yu A, Wegner R, Shepard M. The 5-factor modified frailty index as a prognostic factor of stereotactic radiosurgery for metastatic disease to the brain. Journal Of Neurosurgery 2023, 140: 929-937. PMID: 37856413, DOI: 10.3171/2023.7.jns231214.Peer-Reviewed Original ResearchConceptsProgression-free survivalStereotactic radiosurgeryStereotactic radiosurgery treatmentBrain metastasesOverall survivalRadiation necrosisPrognostic factorsSingle-center retrospective cohort studyPredictive of shorter OSProgression-free survival ratesProgression-free survival intervalSymptomatic radiation necrosisKaplan-Meier analysisRetrospective cohort studyCox proportional hazards modelsPre-frailProportional hazards modelMetastatic diseaseShorter OSPre-frail patientsAdjuvant treatmentHigher frailty scoresCohort studyFrail patientsMFI-5Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma (HCC) With Single Photon Emission Computed Tomography (SPECT) Functional Treatment Planning in Patients With Advanced Hepatic Cirrhosis
Kirichenko A, Uemura T, Liang Y, Hasan S, Abel S, Renz P, Shamsesfandabadi P, Carpenter J, Yin Y, Thai N. Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma (HCC) With Single Photon Emission Computed Tomography (SPECT) Functional Treatment Planning in Patients With Advanced Hepatic Cirrhosis. Advances In Radiation Oncology 2023, 9: 101367. PMID: 38405302, PMCID: PMC10885583, DOI: 10.1016/j.adro.2023.101367.Peer-Reviewed Original ResearchStereotactic body radiation therapySingle-photon Emission Computed TomographyFunctional liver volumeFunctional treatment planningLiver volumeHepatocellular carcinomaEmission Computed TomographyComputed tomographyFunctional hepatic parenchymaTreatment planningCP B/CRadiation therapyLiver transplantationIncidence of radiation-induced liver diseaseFollow-upLiver stereotactic body radiation therapyIn-field local controlTreatment planning computed tomographyRadiation-induced liver diseaseLiver diseaseModel of end-stage liver diseaseLocal controlMonths of radiographic follow-upLiver Disease-Na scoreMedian time to transplant
2022
A Comparison of Single Fraction and Multi Fraction Radiosurgery on the Gamma Knife ICON: A Single Institution Review
Loftus J, Shepard M, Liang Y, Yu A, Karlovits S, Wegner R. A Comparison of Single Fraction and Multi Fraction Radiosurgery on the Gamma Knife ICON: A Single Institution Review. Advances In Radiation Oncology 2022, 8: 101161. PMID: 36845616, PMCID: PMC9943766, DOI: 10.1016/j.adro.2022.101161.Peer-Reviewed Original ResearchFractionated stereotactic radiosurgeryStereotactic radiosurgeryFraction SRSBrain metastasesLocal failurePatients treated with stereotactic radiosurgeryAssociated with local failureReview outcomes of patientsPredictors of worse survivalLocal controlDistant failure ratesGamma Knife IconIntact brain metastasesLarge volume tumorsBrain radiation therapyOutcomes of patientsBiologically Effective DoseKaplan-Meier analysisReceiver operating characteristic analysisPredictors of survivalMalignant solid tumorsReceiver operating characteristic curveOperating characteristic analysisFraction radiosurgeryRadiation therapyUtilization of neoadjuvant stereotactic radiosurgery for the treatment of brain metastases requiring surgical resection: a topic review
Rajkumar S, Liang Y, Wegner R, Shepard M. Utilization of neoadjuvant stereotactic radiosurgery for the treatment of brain metastases requiring surgical resection: a topic review. Journal Of Neuro-Oncology 2022, 160: 691-705. PMID: 36374399, DOI: 10.1007/s11060-022-04190-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain metastasesStereotactic radiosurgeryLeptomeningeal diseaseRadiation necrosisLocal recurrenceSurgical resection of brain metastasesTreatment strategiesClinical trialsResection of brain metastasesRisk of leptomeningeal diseaseRisk of symptomatic RNTreatment of brain metastasesAdjuvant stereotactic radiosurgeryNeoadjuvant stereotactic radiosurgeryProspective clinical trialExtra-cranial tumorsIII clinical trialsAlternative treatment strategiesSequence of surgerySymptomatic RNSurgical resectionRetrospective reviewCase seriesPre-operativelyTumor cellsA volume‐independent conformity index for stereotactic radiosurgery
Oh S, Awan M, Monroe J, Liang Y, Wegner R, Karlovits S, Machtay M, Lo S, Sloan A, Sohn J. A volume‐independent conformity index for stereotactic radiosurgery. Medical Physics 2022, 49: 2931-2937. PMID: 35315939, DOI: 10.1002/mp.15619.Peer-Reviewed Original ResearchConceptsConformity indexVolume dependenceTumor volumePrescription isodose lineSRS/SRT treatmentGaussian functionStereotactic radiosurgery/radiotherapyInfluence of tumor volumeIsodose lineLine contourGamma-knifePlanning acceptanceStereotactic radiosurgeryTarget contourTumor contoursTumorBrain tumorsConformal metricDependenceRadiosurgery/radiotherapySRS/SRTRadiosurgeryPatientsIndexDoseResection cavity dynamics and optimal timing of adjuvant stereotactic radiosurgery for resected brain metastases.
Rajkumar S, Liang Y, Shepard M, Williamson R, Yu A, Karlovits S, Rodney E. Resection cavity dynamics and optimal timing of adjuvant stereotactic radiosurgery for resected brain metastases. Journal Of Radiosurgery And SBRT 2022, 8: 247-255. PMID: 37416330.Peer-Reviewed Original ResearchLocal recurrenceLeptomeningeal diseaseCox proportional hazards modelsBrain metastasesSurgical resectionSRS groupSurgical resection of brain metastasesResection of brain metastasesProbability of local recurrenceAdjuvant stereotactic radiosurgeryNo grade 3Resected Brain MetastasesTime of SRSPredictors of OSOptimal timingPost-operative MRIWeeks of surgeryMann-Whitney U testProportional hazards modelMann-Whitney UAdjuvant SRSStereotactic radiosurgerySubtotal resectionLR rateResection cavity
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