Xinran Liu, MD, PhD
Senior Research ScientistDownloadHi-Res Photo
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Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
Appointments
Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
Appointments
Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
About
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Titles
Senior Research Scientist
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Appointments
Neuroscience
Senior Research ScientistPrimary
Other Departments & Organizations
- Center for Cellular and Molecular Imaging
- Electron Microscopy
- Neuroscience
Education & Training
- Post doctoral training
- University of California San Diego (2000)
- PhD
- Nagoya University School of Medicine (1996)
- MD
- Shanghai Second Military Medical University (1985)
Research
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Overview
As one of the core facilities in the Medical School, We offer a wide range of services from conventional and immuno- electron microscopy to electron tomography. Our experienced staff routinely perform sample processing, sectioning and imaging for a set fee. Our facility is open to users who have had prior training in electron microscopy. The training on use of electron microscope and sample preparation is provided on a one-on-one basis throughout the year.
ORCID
0000-0002-1586-2151- View Lab Website
CCMI Electron Microscopy Core Facility
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xinran Liu's published research.
Publications Timeline
A big-picture view of Xinran Liu's research output by year.
Peter Cresswell, PhD, FRS
Thomas Biederer, PhD
Anthony Koleske, PhD
Carlos Fernandez-Hernando, PhD
Wonnie Ryu, MD, MPH
Christopher Bunick, MD, PhD
17Publications
1,103Citations
Publications
2025
All-optical visualization of specific molecules in the ultrastructural context of brain tissue
M’Saad O, Cairns A, Gulcicek J, Kasula R, Liao J, Kondratiuk I, Bewersdorf E, Kidd P, Falahati H, Gentile J, Niescier R, Watters K, Sterner R, Lee S, Guo X, Liu X, Desir G, De Camilli P, Rothman J, Koleske A, Biederer T, Kuan A, Bewersdorf J. All-optical visualization of specific molecules in the ultrastructural context of brain tissue. Nature Biotechnology 2025, 1-15. PMID: 41299044, DOI: 10.1038/s41587-025-02905-4.Peer-Reviewed Original ResearchCitationsAltmetricTUG protein acts through a disordered region to organize the early secretory pathway
Parchure A, Tejada H, Xi Z, Kim Y, Su M, Yan Y, Julca-Zevallos O, Alcázar-Román A, Villemeur M, Liu X, Toomre D, Raote I, Bogan J. TUG protein acts through a disordered region to organize the early secretory pathway. Nature Communications 2025, 16: 5518. PMID: 40593538, PMCID: PMC12218103, DOI: 10.1038/s41467-025-60691-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRegulation of GLUT4 traffickingEarly secretory pathwayMembrane trafficking pathwaysSoluble cargo proteinsCentral regulatorN-terminal regionBiomolecular condensates in vitroCondensates in vitroNetwork of tubulesCOPII vesiclesCOPI vesiclesCis-GolgiGolgi morphologyCargo proteinsGLUT4 traffickingSecretory pathwayTrafficking pathwaysIntermediate compartmentDisordered regionsDeletionProteinVesiclesCollagen secretionPathwayGolgi
2024
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell surface structuresLymphatic endothelial cellsPublished single-cell RNA-sequencingRNA-seq analysisScRNA-seq analysisSingle-cell RNA sequencingLymphatic systemEndothelial cellsInterleukin-7RNA-seqScRNA-seqExpressed genesRNA sequencingTranscriptomic changesLow abundanceI/R liver injuryGenesIsolation protocolLiver cell typesCell typesIsolation methodLiver of miceHuman liver specimensHeterozygous miceMouse liverCutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation.
Sengupta D, Galicia-Pereyra R, Han P, Graham M, Liu X, Arshad N, Cresswell P. Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation. The Journal Of Immunology 2024, 212: 1063-1068. PMID: 38353614, PMCID: PMC10948299, DOI: 10.4049/jimmunol.2200446.Peer-Reviewed Original ResearchConceptsCross-PresentationTransporter associated with Ag processingExogenous AgCD8-positive T lymphocytesAntigenic peptidesMHC-I moleculesDendritic cellsProteasomal deliveryT lymphocytesCytosolic proteasomeActive proteasomesEndocytic compartmentsTAP-independentLumen of phagosomesSubcellular compartmentsEndoplasmic reticulumEndolysosomal vesiclesMHC-IAg processingBind to MHC-IProteasome
2023
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis
Ahangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisMiR-33MiR-33 levelsSpecific genetic ablationBronchoalveolar lavage cellsNovel therapeutic approachesMitochondrial homeostasisFatty acid metabolismMacrophages protectsBleomycin injuryLavage cellsLung fibrosisHealthy controlsInflammatory responseTherapeutic approachesImmunometabolic responsesCholesterol effluxFibrosisFatal diseasePharmacological inhibitionSterol regulatory element-binding protein (SREBP) genesGenetic ablationMacrophagesEx vivo mouse
2022
Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings
Roy S, Sarhan J, Liu X, Murphy M, Bunick C, Choate K, Damsky W, McNiff J. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. British Journal Of Dermatology 2022, 188: 574-576. PMID: 36763786, DOI: 10.1093/bjd/ljac146.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVirus infectionUnusual clinical findingsElectron microscopy findingsEccrine epitheliumSquamous syringometaplasiaClinical findingsSitu hybridizationEccrine ductsMicroscopy findingsSyringometaplasiaUltrastructural characteristicsInfectionViral mRNAsFindingsPatientsHistopathologicalDiseaseEpitheliumProteasomal degradation within endocytic organelles can mediate antigen cross- presentation
Sengupta D, Graham M, Liu X, Cresswell P. Proteasomal degradation within endocytic organelles can mediate antigen cross- presentation. Molecular Immunology 2022, 150: 23. DOI: 10.1016/j.molimm.2022.05.080.Peer-Reviewed Original ResearchConceptsDendritic cellsMHC-I moleculesMouse bone marrow-derived dendritic cellsBone marrow-derived dendritic cellsMarrow-derived dendritic cellsAntigen processingConventional antigen processingMouse dendritic cellsMHC-I-peptide complexesSurface MHCMHCSurface expressionProteasome inhibitionPeptide loadingHuman B2Cell phagosomesCell typesActive proteasomesSpecific peptidesCellsPeptidesEndocytic compartmentsProteasomal degradationEndocytic pathwayRetro-2 alters Golgi structure
Yue X, Gim B, Zhu L, Tan C, Qian Y, Graham M, Liu X, Lee I. Retro-2 alters Golgi structure. Scientific Reports 2022, 12: 14975. PMID: 36056100, PMCID: PMC9438350, DOI: 10.1038/s41598-022-19415-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRetro-2Golgi apparatusGolgi structureER exit site proteinGolgi structural proteinsGolgi stacksER exitGolgi organizationIndividual cisternaeGolgiStructural proteinsProtein secretionPerinuclear areaUltra-structural studiesEM tomographyVesicular profilesHuman lung cellsPartial disassemblySyntaxin5ProteinCultured human lung cellsCell depletionDisassemblyUltrastructureCells
2021
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling
Kawamura Y, Murtada S, Gao F, Liu X, Tellides G, Humphrey J. Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. Journal Of The Mechanical Behavior Of Biomedical Materials 2021, 116: 104264. PMID: 33508556, PMCID: PMC7959590, DOI: 10.1016/j.jmbbm.2020.104264.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAortic dissectionMouse modelAortic wallCompensatory changesThoracic aortic dissectionMuscle-specific disruptionSmooth muscle cellsLoss of TGFβMedial integrityAortic ruptureClinical presentationMuscle cellsQuantitative histologyMatrix turnoverTGFβ receptorsDissectionWall stressTGFβType IIndividual subjectsSpecific disruptionVivo valuesExaminationRupture
2019
Parasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti
Mamoun C, Thekkiniath J, Kilian N, Lawres L, Gewirtz M, Abraham A, Graham M, Liu X, Ledizet M. Parasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti. The FASEB Journal 2019, 33: 649.2-649.2. DOI: 10.1096/fasebj.2019.33.1_supplement.649.2.Peer-Reviewed Original ResearchCitationsConceptsMajor morphogenetic changesImmunoelectron microscopy analysisB. microtiProtein exportPhylum ApicomplexaMorphogenetic changesSecreted proteinsCell fractionationIntraerythrocytic developmentCanonical motifsExport systemPlasma membraneErythrocyte cytoplasmMajor immunodominant antigenBabesia microtiParasitophorous vacuoleHost erythrocyteWorldwide geographic distributionMalaria-like illnessGeographic distributionMalaria parasitesCell environmentProteinFASEB JournalFull-text articles
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Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
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