Weizhe Zhong
Postdoctoral AssociateAbout
Research
Publications
2026
IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis
Zhong W, Ricci-Azevedo R, Wang S, Cooper S, Ma J, Swartzwelter B, Xhafi F, Zhao D, Gao H, Shah V, Liangpunsakul S, Ouyang X, Mehal W, Cao S, Sun Z, Peiffer B, Iwakiri Y, Vassallo R, Liu M. IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis. Hepatology Communications 2026, 10: e0967. PMID: 42275578, PMCID: PMC13263083, DOI: 10.1097/hc9.0000000000000967.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsAlcohol-associated hepatitisCD8 T cellsCD8 tissue-resident memory T cellsLiver sinusoidal endothelial cellsMemory T cellsT cell interactionsT cellsSingle-cell RNA sequencingCD8 T cell subsetsLipopolysaccharide-induced liver injuryCD8 TRM cellsT cell subsetsT cell receptor stimulationActivation-induced cell deathIn vitro co-cultureBlood immune cellsIn vivo neutralizationCell deathProinflammatory cytokine productionInflammatory liver conditionSinusoidal endothelial cellsSevere AHTRM cellsPI3K-Akt pathway
2025
New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting
Tschann M, Vachharajani V, Redmond E, Hoisington A, Cohen S, New-Aaron M, Llorente C, Paloczi J, Keating C, Rungratanawanich W, Burnham E, Callaci J, Raju P, Zhong W, Mandal A, Zimmerly J, Nuncio A, Mandrekar P, McCullough R, McMahan R, Wyatt T, Yeligar S, Kovacs E, Choudhry M. New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 2025, 126: 1-10. PMID: 40267994, PMCID: PMC12177220, DOI: 10.1016/j.alcohol.2025.04.002.Peer-Reviewed Original ResearchConceptsAlcohol and Immunology Research Interest GroupResearch Interest GroupHealth sciences campusEffects of alcohol useOrgan dysfunctionImpact of alcoholEmergency careCardiovascular healthTissue injuryYear's meetingHost immunityAlcohol useOrgan functionSciences CampusInflammationGut microbiomeInterest groupsSessionsImmunity
2024
41. Liver sinusoidal endothelial cells exhibit a tolerance-like innate immune memory in response to priming by interferons
Zhong W, Swartzwelter B, Xhafi F, Liu M. 41. Liver sinusoidal endothelial cells exhibit a tolerance-like innate immune memory in response to priming by interferons. Alcohol 2024, 121: 219-220. DOI: 10.1016/j.alcohol.2024.10.044.Peer-Reviewed Original Research