Dejian Zhao, PhD
Associate Research Scientist in GeneticsCards
About
Research
Publications
2026
IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis
Zhong W, Ricci-Azevedo R, Wang S, Cooper S, Ma J, Swartzwelter B, Xhafi F, Zhao D, Gao H, Shah V, Liangpunsakul S, Ouyang X, Mehal W, Cao S, Sun Z, Peiffer B, Iwakiri Y, Vassallo R, Liu M. IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis. Hepatology Communications 2026, 10: e0967. PMID: 42275578, PMCID: PMC13263083, DOI: 10.1097/hc9.0000000000000967.Peer-Reviewed Original ResearchRegulation of chromatin dynamics by a calcium-dependent nucleoskeleton
González M, Rodrigues M, Diprima S, Zhao D, Bassani T, Fernandez C, Kruglov E, Nathanson M, Gomes D. Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton. Journal Of Biological Chemistry 2026, 302: 113104. PMID: 42103234, PMCID: PMC13254598, DOI: 10.1016/j.jbc.2026.113104.Peer-Reviewed Original ResearchPharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish
Jamadagni P, Dai Y, Liu Y, Mendes H, Pruitt A, Khan S, Yang L, Huang T, Huang X, Deans P, Zhao D, Xu G, Liu Y, Li N, Wu W, Fitzpatrick S, Neelakantan U, Chen T, Szialta C, Jin D, Lacadie C, Umlauf S, Papademetris X, Surovtseva Y, Brennand K, Wang Z, Hoffman E. Pharmaco-behavioral profiling identifies suppressors of autism gene–associated phenotypes in zebrafish. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2518846123. PMID: 41838920, PMCID: PMC13012064, DOI: 10.1073/pnas.2518846123.Peer-Reviewed Original Research
2025
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis
Bacchiocchi A, Mak M, Khan Z, Gong X, Sznol M, Na Z, Su H, Chan L, Yan Q, Zhao D, Mortlock R, Knight J, Slavoff S, Halaban R. LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis. Oncogene 2025, 44: 3974-3984. PMID: 40885854, PMCID: PMC12500468, DOI: 10.1038/s41388-025-03538-2.Peer-Reviewed Original ResearchAuto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan
Jeong D, Lee D, Kim S, Jeoung S, Zhao D, Knight J, Lam T, Jin J, Lee H, Hochstrasser M, Ryu H. Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan. Nature Communications 2025, 16: 3735. PMID: 40254622, PMCID: PMC12009981, DOI: 10.1038/s41467-025-58925-w.Peer-Reviewed Original ResearchSrsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis
Yang X, Zhang X, Tian Y, Yang J, Jia Y, Xie Y, Cheng L, Chen S, Wu L, Qin Y, Zhao Z, Zhao D, Wei Y. Srsf3-Dependent APA Drives Macrophage Maturation and Limits Atherosclerosis. Circulation Research 2025, 136: 985-1009. PMID: 40160097, DOI: 10.1161/circresaha.124.326111.Peer-Reviewed Original Research
2024
TET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchUp-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchAuto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan.
Ryu HY, Jeong DW, Kim SY, Jeoung SW, Zhao D, Knight J, Lam T, Jin JH, Lee HS, Hochstrasser M. Auto-sumoylation of the Ubc9 E2 SUMO-conjugating Enzyme Extends Cellular Lifespan. Res Sq 2024 PMID: 38562857, DOI: 10.21203/rs.3.rs-4016606/v1.Peer-Reviewed Original ResearchASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts
Hu B, Wiesehöfer M, de Miguel F, Liu Z, Choi J, Melnick M, Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen D, Politi K. ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts. Cancer Research 2024, 84: 1303-1319. PMID: 38359163, PMCID: PMC11142404, DOI: 10.1158/0008-5472.can-23-0438.Peer-Reviewed Original Research
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