Veronica Chiang, MD, FAANS
Professor of NeurosurgeryCards
Additional Titles
Assistant Dean for Admissions, Medical Education
Associate Vice Chair of Academic Affairs
Director, Stereotactic Radiosurgery
Director, Gamma Knife Center, YNHH
Director, Stereotactic Radiosurgery Fellowship
Administrative Support
Publications Overview
- 281 Publications
- 14,275 Citations
- 93 Yale Co-Authors
Additional Titles
Assistant Dean for Admissions, Medical Education
Associate Vice Chair of Academic Affairs
Director, Stereotactic Radiosurgery
Director, Gamma Knife Center, YNHH
Director, Stereotactic Radiosurgery Fellowship
Administrative Support
Publications Overview
- 281 Publications
- 14,275 Citations
- 93 Yale Co-Authors
Additional Titles
Assistant Dean for Admissions, Medical Education
Associate Vice Chair of Academic Affairs
Director, Stereotactic Radiosurgery
Director, Gamma Knife Center, YNHH
Director, Stereotactic Radiosurgery Fellowship
Administrative Support
Publications Overview
- 281 Publications
- 14,275 Citations
- 93 Yale Co-Authors
About
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Titles
Professor of Neurosurgery
Assistant Dean for Admissions, Medical Education; Associate Vice Chair of Academic Affairs; Director, Stereotactic Radiosurgery; Director, Gamma Knife Center, YNHH; Director, Stereotactic Radiosurgery Fellowship
Biography
Dr Chiang leads the Brain Metastasis Program at Yale. This Program is comprised of a multi-disciplinary group of physicians in the specialty areas of Medical Oncology, Radiation Oncology, Neurosurgery, Radiology, Pathology and Neuro-Oncology. This nationally unique program is specifically dedicated to the coordinated clinical management of patients with Brain Metastases as well as the performance of basic science, translational and clinical trial research in this area. This group meets at least once weekly at a CME-accredited Tumor Boardto discuss both the clinical and potential research pertinent to the management of our cancer patients with brain and spine metastases. Watch a video with Dr. Veronica Chiang>>
As the lead Neurosurgeon in this Program, Dr Chiang specializes in:
- Standard neurosurgical management of brain metastases.
- Gamma Knife radiosurgery treatment of brain metastases. This focused radiation tool can be used both as first line treatment, as well as salvage following whole brain radiation therapy and or prior radiosurgery. Particular interest in melanoma and lung cancer.
- The management of post-radiosurgery complications – tumor regrowth versus adverse radiation effects (radiation induced inflammation)
- Clinical Trials using novel immunotherapies for treatment of brain metastases (Clinical Trials.gov: Identifier # NCT02085070)
Dr Chiang has joint appointments in the Departments of Neurosurgery and Radiation Oncology here at Yale University School of Medicine. As the Medical Director of the Gamma Knife Center since 2006, Dr Chiang has participated in state and national discussions regarding the development of guidelines for the radiosurgical management of brain metastases. She is known nationally and internationally for her research on the clinical as well as radiological outcomes of radiosurgical treatment of brain metastases. (ClinicalTrials.gov Identifier #:NCT02005614). She has also extensively published on the efficacy and outcome of radiosurgery for many other brain lesions.
In addition, she is the director of the Yale New Haven Hospital Radiosurgery Fellowship Program for Neurosurgery and Radiation Oncology.
Laser Thermal Ablation (LTA)
LTA is the use of heat emitted from a laser fiber to treat lesions in the brain. It is a cutting edge, minimally invasive technology that allows neurosurgeons to treat lesions inside the skull through a small incision visualized in real time using MRI monitoring. (link to Monteris website – MyBrainTumorOptions.com).
As one of the first and longest users of MRI-guided LTA in the USA, Dr Chiang now has over a decade of experience treating a variety of brain tumors and is a national leader in the use of LTA treatment for brain metastases that have regrown following radiosurgery where no other treatment options have been available.
She was the lead investigator on a clinical trial studying quality of life in patients with brain metastases regrowing after radiosurgery and the impact of LTA (LAASR study – Identifier #: NCT01651078) and a key participant in the LAANTERN data repository.
Dr Chiang uses microsurgery, gamma knife radiosurgery and LTA in conjunction with targeted and immunotherapies in the multidisciplinary treatment of all solid organ cancer types especially including breast cancer, lung cancer and melanoma. In collaboration with these disease teams she participates in ongoing clinical trials to improve management and outcome for brain metastases patients.
Appointments
Office of the Dean, School of Medicine
Assistant DeanDualNeurosurgery
ProfessorPrimaryTherapeutic Radiology
ProfessorSecondary
Other Departments & Organizations
- Brain Tumor Surgery
- Center for Brain & Mind Health
- DNA Damage and Genome Integrity
- Gamma Knife Center
- Gamma Knife Radiosurgery
- Neurosurgery
- Office of the Dean, School of Medicine
- Slayman House Affiliates
- SPORE in Lung Cancer
- Therapeutic Radiology
- Yale Cancer Center
- Yale Medicine
- Yale Ventures
Education & Training
- Resident
- Yale University School of Medicine (2000)
- Fellow
- Johns Hopkins University School of Medicine (2000)
- Fellow
- Yale-New Haven Hospital (1994)
- MD
- University of Western Australia (1992)
- BMedSci
- University of Western Australia
Research
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Overview
Medical Research Interests
ORCID
0000-0003-1882-3876
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Harriet Kluger, MD
James B. Yu, MD, MHS, FASTRO
Amit Mahajan, MD
Lucia Jilaveanu, MD, PhD
Sarah Goldberg, MD, MPH
Anna Arnal Estape, PhD, BS
Brain Neoplasms
Radiosurgery
Neoplasm Metastasis
Neurosurgery
Publications
2025
Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy
Landazuri P, Cheng J, Leuthardt E, Kim A, Southwell D, Fecci P, Neimat J, Sun D, Lega B, Panov F, Chiang V, Abel T, Ben-Haim S, Piccioni D, Shih J, Palys V, Rodriguez A, Bandt S, Petronio J, Lacroix M, Baumgartner J. Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy. JAMA Neurology 2025, 82: 915-924. PMID: 40622685, PMCID: PMC12235534, DOI: 10.1001/jamaneurol.2025.1897.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLaser interstitial thermal therapyDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsySeizure outcomeInterstitial thermal therapyTemporal lobe epilepsyFollow-upProcedural outcomesSafety dataQuality of lifeLobe epilepsyIntensive care unit timeMonths of follow-upAssociated with seizure outcomeYears of follow-upProspective multicenter registryPostsurgical seizure outcomeMesial temporal sclerosisIntensive care unitThermal therapyQuality of life improvementQuality of life scoresInternational League Against EpilepsyLength of stayMagnetic resonance imagingOutcome Evaluation of Volume-Staged Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations.
Mantziaris G, Hajikarimloo B, Tos S, Pikis S, Chan J, Sneed P, McDermott M, Seymour Z, Grills I, Nabeel A, Reda W, Tawadros S, Abdelkarim K, El-Shehaby A, Emad R, Bin-Alamer O, Lunsford L, Niranjan A, Peker S, Samanci Y, Lee C, Yang H, Sheehan D, Sheehan K, Liscak R, Chytka T, Alzate J, Kondziolka D, Meng Y, Martinez Moreno N, Martinez Álvarez R, Hallan D, Fritch C, Jareczek F, Sciscent B, Mathieu D, Carrier L, Abdelsalam A, Starke R, Benjamin C, Almeida T, Pratap Singh S, Tripathi M, Speckter H, Lazo E, Chen C, Esquenazi Y, Becerril-Gaitan A, Amsbaugh M, Blanco A, Upadhyay R, Palmer J, Franzini A, Picozzi P, Lanterna L, Bowden G, Peterson J, Warnick R, Chiang V, Ishaque M, Protopapa M, Sheehan J. Outcome Evaluation of Volume-Staged Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations. Neurosurgery 2025 PMID: 40788018, DOI: 10.1227/neu.0000000000003682.Peer-Reviewed Original ResearchAltmetricConceptsSingle-session stereotactic radiosurgeryArteriovenous malformationsVS-SRSPrescription doseObliteration rateFavorable outcomeStereotactic radiosurgeryAdverse radiation effect ratesVolume-staged stereotactic radiosurgeryMedian prescription doseAdverse radiation effectsMulticenter retrospective cohortArteriovenous malformation nidusClinical follow-upCerebral arteriovenous malformationsReduced treatment volumesNidus volumeMedian agePatient yearsDiffuse nidusRetrospective cohortRepeated TreatmentFollow-upTreatment volumeTreatment planningBIOM-05 CHARACTERIZATION OF TUMOR-DERIVED DNA MUTATIONS, COPY NUMBER CHANGES, AND METHYLATED FRAGMENTS WITHIN CEREBROSPINAL FLUID AND PLASMA FROM PATIENTS UNDERGOING SURGERY FOR LUNG CANCER BRAIN METASTASIS
Dolezal D, Chande S, Kandigian S, Huang Y, Walsh M, Arnal-Estapé A, Bonora G, Du P, Squatrito M, Cross D, Blondin N, Goldberg S, Jia S, Chiang V, Nguyen D. BIOM-05 CHARACTERIZATION OF TUMOR-DERIVED DNA MUTATIONS, COPY NUMBER CHANGES, AND METHYLATED FRAGMENTS WITHIN CEREBROSPINAL FLUID AND PLASMA FROM PATIENTS UNDERGOING SURGERY FOR LUNG CANCER BRAIN METASTASIS. Neuro-Oncology Advances 2025, 7: ii7-ii7. PMCID: PMC12342479, DOI: 10.1093/noajnl/vdaf123.025.Peer-Reviewed Original ResearchConceptsCopy number variantsLeptomeningeal diseaseCerebrospinal fluidDifferentially methylated fragmentsSurgical managementManagement of brain metastasesNon-small cell lung cancerMarkers associated with disease progressionGenome-wide copy number variantsCell lung cancerCopy number changesCell-free DNACNS progressionCtDNA levelsBrain metastasesMRD assaysCtDNA mutationsOverall survivalCtDNA methylationTumor fractionLung cancerUltradeep sequencingDisease progressionDNA methylation assaysAberrant methylationTRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES
Lu B, Yahsi B, Gu J, Coburn J, Kasbe M, Arnal-Estape A, Sohn K, Whitehead K, Mosharraf M, Nguyen D, Zhao H, Lucca L, Schalper K, Chiang V, Hafler D, Lee M. TRLS-11 UNCOVERING ANTIGEN-SPECIFICITY OF INTRATUMORAL CD8+ T CELLS IN NON-SMALL CELL LUNG CANCER BRAIN METASTASES. Neuro-Oncology Advances 2025, 7: ii36-ii36. PMCID: PMC12342607, DOI: 10.1093/noajnl/vdaf123.134.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCD8+ T cellsIntratumoral T cellsPatient lung tumorsT cellsBrain metastasesAntigen-SpecificTumor reactivityClonal repertoireNon-small cell lung cancer brain metastasisIntratumoral CD8+ T cellsPublic antigensTumor-infiltrating T cellsCD8+ T cellsAntitumor T-cell functionDegree of clonal expansionT-cell receptor (TCR) sequencingT-cell therapyImmune-modulating therapiesTumor-associated antigensCell lung cancerT cell functionAntigenic reactivitySomatic single-nucleotide variantsResected tumorInternational multicenter study of stereotactic radiosurgery for bladder cancer brain metastases
Perron R, Iorio-Morin C, Chytka T, Simonova G, Chiang V, Singh C, Niranjan A, Wei Z, Lunsford L, Peker S, Samanci Y, Peterson J, Ross R, Rusthoven C, Lee C, Yang H, Yener U, Sheehan J, Kondziolka D, Mathieu D. International multicenter study of stereotactic radiosurgery for bladder cancer brain metastases. Journal Of Neuro-Oncology 2025, 174: 235-241. PMID: 40249513, DOI: 10.1007/s11060-025-05039-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCancer brain metastasesInternational Radiosurgery Research FoundationStereotactic radiosurgeryBrain metastasesBrain metastases treated with stereotactic radiosurgeryFollow-upStudy of stereotactic radiosurgeryTime of stereotactic radiosurgeryEvaluate stereotactic radiosurgeryFractionated stereotactic radiosurgeryMedian marginal doseNon-urothelial histologyBrain metastasis diagnosisAdverse radiation effectsImaging follow-upInternational multicenter studyMarginal doseResults103 patientsMedian KPSTumor controlSystemic metastasesLeptomeningeal disseminationMedian survivalSurgical resectionCorticosteroid intakeImproved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment
Sperduto P, Marqueen K, Chang E, Li J, Davies M, Ebner D, Breen W, Lamba N, Shih H, Edwards D, Kim M, Mahal A, Rahman R, Ankrah N, Boggs D, Lewis C, Hyer D, Buatti J, Johri F, Soliman H, Masucci L, Roberge D, Aneja S, Chiang V, Phuong C, Braunstein S, Dajani S, Sachdev S, Wan Z, Niedzwiecki D, Vaios E, Kirkpatrick J, Pasetsky J, Wang T, Kutuk T, Kotecha R, Ross R, Rusthoven C, Nakano T, Tawbi H, Mehta M. Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment. Journal Of Clinical Oncology 2025, 43: 1910-1919. PMID: 40245362, PMCID: PMC12119226, DOI: 10.1200/jco-24-01351.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGraded Prognostic AssessmentMelanoma brain metastasesPrognostic factorsPrognostic assessmentAbsence of extracranial metastasesGPA 0Multi-institutional retrospective databaseTreatments associated with survivalAnalysis of prognostic factorsMedian follow-up timeModern multimodality therapyKarnofsky performance statusClinical trial eligibilityBrain metastasesExtracranial metastasesMedian survivalMelanoma patientsMultimodal therapyPerformance statusMultidisciplinary treatmentImproved survivalRetrospective databaseTrial eligibilityTherapeutic modalitiesClinical trialsPhase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases
Weiss S, Djureinovic D, Wei W, Tran T, Austin M, Markowitz J, Eroglu Z, Khushalani N, Hegde U, Cohen J, Sznol M, Anderson G, Johnson B, Piteo C, Mahajan A, Adeniran A, Jilaveanu L, Goldberg S, Chiang V, Forsyth P, Kluger H. Phase II Trial of Pembrolizumab in Combination With Bevacizumab for Untreated Melanoma Brain Metastases. Journal Of Clinical Oncology 2025, 43: 1685-1694. PMID: 40048689, PMCID: PMC12058415, DOI: 10.1200/jco-24-02219.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMelanoma brain metastasesOverall survivalBrain metastasesAnti-vascular endothelial growth factor therapyMedian intracranial progression-free survivalFour-year OS ratesIntracranial progression-free survivalResponse rateCirculating angiopoietin-2Median overall survivalTrial of pembrolizumabYears of pembrolizumabDose of bevacizumabProgression-free survivalPhase II trialGrowth factor therapyAdverse event ratesAssociated with responseOS ratesPD-1Radiation necrosisLocal therapyOn-therapyMetastatic tumorsFactor therapyThe Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients
Antonios J, Adenu-Mensah N, Theriault B, Millares-Chavez M, Huttner A, Aboian M, Chiang V. The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients. Clinical And Translational Neuroscience 2025, 9: 10. DOI: 10.3390/ctn9010010.Peer-Reviewed Original ResearchCitationsConceptsCentral vein signRadiation necrosisTumor progressionDiagnosis of radiation necrosisDifferentiate RNCerebral radiation necrosisIntracranial metastatic diseaseCancer therapy responseMetastatic cancer patientsNon-invasive markerMetastatic diseaseSurgical biopsyTherapy responsePredictive markerPatient cohortPrimary treatmentRadiological toolsCancer patientsRadiological imagingTreatment decisionsPerivascular spacesPatientsTreatmentNecrosisMarkersSurvival of patients with metastatic renal cell carcinoma with or without brain metastases.
Hurwitz M, Considine B, Hasson N, Savion Gaiger N, Nelson M, Chiang V, Kluger H, Braun D, Schoenfeld D, Sznol M, Leapman M. Survival of patients with metastatic renal cell carcinoma with or without brain metastases. Journal Of Clinical Oncology 2025, 43: 476-476. DOI: 10.1200/jco.2025.43.5_suppl.476.Peer-Reviewed Original ResearchCitationsConceptsMetastatic renal cell carcinomaImmune checkpoint inhibitorsClear cell RCCRenal cell carcinomaImmune checkpoint inhibitor therapyMetastatic clear cell RCCBrain metastasesOverall survivalCell carcinomaImmune checkpoint inhibitor eraPrevalence of brain metastasesMultivariate Cox proportional hazards modelAssociated with poor survivalMedian overall survivalAssociated with poor prognosisCompare overall survivalImproved overall survivalAdverse prognostic indicatorDevelopment of BMSurvival of patientsKaplan-Meier analysisYale Cancer CenterRetrospective cohort studyCox proportional hazards modelsProportional hazards model
2024
Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment
Singh K, Abdou H, Panth N, Chiang V, Buono F, Schwartz N, Mahajan A. Comparing the Accuracy and Reliability of ABC/2 and Planimetry for Vestibular Schwannoma Volume Assessment. Otology & Neurotology 2024, 46: 196-200. PMID: 39792983, DOI: 10.1097/mao.0000000000004392.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsTumor volume assessmentABC/2 methodVestibular schwannomaVolume assessmentPlanimetry methodTumor volumeTumor volume changesFollow-up scansOverestimate tumor volumePatients' quality of lifeTumor sizeRetrospective reviewIntracranial tumorsImprove clinical decision makingSubgroup analysisVolumetric assessmentTumorClinical decision makingQuality of lifePatients' qualityPatientsClinical settingPlanimetryImaging techniquesPositive correlation
Clinical Trials
Current Trials
Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
HIC ID1603017333RoleSub InvestigatorPrimary Completion Date06/20/2026Recruiting Participants
Academic Achievements & Community Involvement
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Honors
honor First Class Honours (Thesis degree BMedSci)
01/01/1991UnknownDetailsUnited Stateshonor Asthma Foundation of Australia Scholarship
01/01/1990UnknownDetailsUnited Stateshonor National Health and Medical Research Council of Australia Medical Undergraduate Scholarship
01/01/1988UnknownDetailsUnited States
Clinical Care
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Overview
Veronica Chiang MD, a neurosurgeon and director of the Gamma Knife Center at Yale New Haven Hospital, specializes in treating metastatic cancer to the brain using a multidisciplinary approach. She offers both standard neurosurgical surgery as well as cutting edge procedures such as laser thermocoagulation. In addition, she specializes in the use of radiosurgery. This technique allows doctors to transmit radiation directly to tumor cells and avoid radiating healthy brain cells, which can help improve patients’ quality of life after treatment.
Dr. Chiang acknowledges that brain surgery can be a big step for patients and provides as much information about the procedure as possible. “Knowledge helps people deal with how scary it might feel,” she says.
In addition to treating patients, Dr. Chiang conducts research on managing patient care through multidisciplinary approaches, and how technologies like thermocoagulation and radiosurgery can help patients with brain metastases. “The neurological system is one of the last areas where there’s very little known about it. I love learning about it and figuring out how to improve patient’s lives,” she says.
Clinical Specialties
Fact Sheets
Gamma Knife Radiosurgery
Learn More on Yale MedicineMetastatic Brain Tumors
Learn More on Yale MedicineRadiation Therapy with Gamma Knife
Learn More on Yale MedicinePrimary Brain Tumors
Learn More on Yale Medicine
Board Certifications
Neurological Surgery
- Certification Organization
- AB of Neurological Surgery
- Latest Certification Date
- 2014
- Original Certification Date
- 2003
Yale Medicine News
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News
- December 22, 2025
Clinical Trials Target Brain Metastases
- September 29, 2025
Yale's Review of Advances in Oncology: Highlights from the ASCO Annual Meeting 2025
- May 09, 2025
Medical Marvels: Gamma Knife Treatment for Brain Cancer and New Uses for Lupus Antibodies
- December 13, 2024
Ten Years of Advances: The Story of an ALK-Positive Lung Cancer Survivor
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Contacts
Administrative Support
Locations
Yale Neurosurgery
Academic Office
Tompkins Memorial Pavilion
789 Howard Avenue, Ste 4th Floor
New Haven, CT 06519
Fax
203.785.2098Appointments
203.785.2808Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.