Timothy Quan, MD
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About
Biography
Dr. Quan graduated with a B.S. from Yale College and a M.D. from S.U.N.Y. Health Science Center at Brooklyn. He completed his residency in Internal Medicine Primary Care and fellowship in Rheumatology through the Yale School of Medicine. His current research interests include investigating the role of viruses in autoimmunity and the molecular and cellular basis of fibrosis.
Appointments
Rheumatology
Assistant Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- SUNY at Brooklyn (1996)
- BS
- Yale (1990)
Research
Overview
Dr. Quan’s project, The Role of Dendritic Cells in Interstitial Lung Disease Associated with Rheumatoid Arthritis, tests a new model which examines fibrosis in the context of well known inflammatory cells, myeloid dendritic cells (mDC), that may link inflammation to fibrosis. Myeloid dendritic cells promote fibrosis by producing collagen and are thus key players in interstitial lung disease associated with rheumatoid arthritis.
Research at a Glance
Yale Co-Authors
Frequent collaborators of Timothy Quan's published research.
Publications Timeline
A big-picture view of Timothy Quan's research output by year.
Shawn Cowper, MD
Insoo Kang, MD
Joseph Craft, MD
Richard Bucala, MD, PhD
6Publications
968Citations
Publications
2007
Culture and Analysis of Circulating Fibrocytes
Quan T, Bucala R. Culture and Analysis of Circulating Fibrocytes. 2007, 135: 423-434. DOI: 10.1385/1-59745-401-x:423.Peer-Reviewed Original ResearchCulture and Analysis of Circulating Fibrocytes
Quan TE, Bucala R. Culture and Analysis of Circulating Fibrocytes. Methods In Molecular Medicine 2007, 135: 423-434. PMID: 17951676, DOI: 10.1007/978-1-59745-401-8_28.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPeripheral bloodDifferent mammalian speciesMammalian speciesMatrix proteinsHematopoetic originPeripheral blood fibrocytesCultured cellsFlow cytometry analysisUnique surface phenotypeCell surface markersModel systemCirculating FibrocytesWound repairCytometry analysisBlood fibrocytesMononuclear cellsSurface phenotypeWound chambersGrowth characteristicsCellsBuffy coatFibrocytesSurface markersBloodSpecies
2006
The role of circulating fibrocytes in fibrosis
Quan TE, Cowper SE, Bucala R. The role of circulating fibrocytes in fibrosis. Current Rheumatology Reports 2006, 8: 145-150. PMID: 16569374, DOI: 10.1007/s11926-006-0055-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPulmonary fibrosisFunctions of fibrocytesAreas of inflammationSerum amyloid PTissue repair responseFibrocyte traffickingInflammatory cytokinesPeripheral bloodMalignant potentialFibrotic lesionsStromal responseIL-1Skin lesionsPathologic fibrosisNew therapiesAmyloid PHypertrophic scarsTissue damageMatrix metalloproteinasesFibrosisRemodeling responseTumor invasionFibrocytesContractile myofibroblastsExperimental model
2004
Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies
Kang I, Siperstein R, Quan T, Breitenstein ML. Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies. Clinical Rheumatology 2004, 23: 509-515. PMID: 15801070, DOI: 10.1007/s10067-004-0937-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnti-dsDNA AbsLow titer ANAsANA titersDsDNA AbsImmunofluorescence patternDsDNA antibodiesAnti-extractable nuclear antigensLow titersHigh titer ANAHomogeneous patternUtility of ageANA test resultsFemale preponderanceANA patternsDecreased frequencyLogistic regressionTitersNuclear antigenROC curveCurve areaPatientsAntibodiesAgeANAAssociationCirculating fibrocytes: collagen-secreting cells of the peripheral blood
Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. The International Journal Of Biochemistry & Cell Biology 2004, 36: 598-606. PMID: 15010326, DOI: 10.1016/j.biocel.2003.10.005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNephrogenic fibrosing dermopathyAntigen-presenting cellsNaïve T cellsNew disease entityPresentation of antigensImportant etiopathogenic roleRenal insufficiencyUnique cell populationFibrosing disorderLocal tissue environmentImmunological markersInflammatory cytokinesPeripheral bloodEtiopathogenic roleFibrotic lesionsGranuloma formationAntigen presentationDisease entityT cellsHypertrophic scarsMatrix metalloproteinasesRemodeling responseFibrocytesContractile myofibroblastsCollagen-secreting cellsDefective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus
Kang I, Quan T, Nolasco H, Park SH, Hong MS, Crouch J, Pamer EG, Howe JG, Craft J. Defective Control of Latent Epstein-Barr Virus Infection in Systemic Lupus Erythematosus. The Journal Of Immunology 2004, 172: 1287-1294. PMID: 14707107, DOI: 10.4049/jimmunol.172.2.1287.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdultB-Lymphocyte SubsetsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCytomegalovirusEpitopes, T-LymphocyteEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansLeukocytes, MononuclearLupus Erythematosus, SystemicLymphocyte CountMaleMiddle AgedSeverity of Illness IndexViral LoadVirus LatencyConceptsSystemic lupus erythematosusEBV viral loadT cell responsesViral loadT cellsIFN-gammaCell responsesEBV infectionLupus erythematosusHealthy controlsEBV-specific T-cell responsesVirus-specific T cell responsesLatent Epstein-Barr virus (EBV) infectionEBV-specific immune responsesEpstein-Barr virus infectionAltered T-cell responsesDefective controlFrequency of CD69HLA-A2 tetramersTetramer-positive CD8Latent EBV infectionEBV-specificImmunosuppressive medicationsDisease activityLupus patients