Taylor Adams

2025

• A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases

  Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 1-26. PMID: 40542107, DOI: 10.1038/s41551-025-01423-7.

  Peer-Reviewed Original Research

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• Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia

  Manning E, Ramachandra A, Sharma P, Nikola F, De Man R, Doddaballapur P, Raredon M, Szafron J, Baernthaler T, Justet A, Akingbesote N, Perry R, Adams T, Cavinato C, Yan X, Tellides G, Kaminski N, Humphrey J. Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3336-a3336. DOI: 10.1164/ajrccm.2025.211.abstracts.a3336.

  Peer-Reviewed Original Research

• The Potential Role of miR205 and miR205HG in Pulmonary Fibrosis

  Anderson S, Johad K, Ahangari F, Justet A, Adams T, Yan X, Kaminski N. The Potential Role of miR205 and miR205HG in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4662-a4662. DOI: 10.1164/ajrccm.2025.211.abstracts.a4662.

  Peer-Reviewed Original Research

• Early IPF Is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche

  Justet A, Adams T, Khoury J, Balayev A, Abu Hussein N, Schupp J, Zhao A, Manning E, Ahangari F, Yan X, Ravaglia C, Tomassetti S, Poletti V, Kaminski N. Early IPF Is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7109-a7109. DOI: 10.1164/ajrccm.2025.211.abstracts.a7109.

  Peer-Reviewed Original Research

• The Potential Role of GPR87 in the Development of Pulmonary Fibrosis

  Khoury J, Ahangari F, Justet A, Adams T, Manning E, Mcdonough J, Anderson S, Nekola F, Beermann M, Bauer Y, Gomez J, Kaminski N. The Potential Role of GPR87 in the Development of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7110-a7110. DOI: 10.1164/ajrccm.2025.211.abstracts.a7110.

  Peer-Reviewed Original Research

• Single-cell Analysis Reveals Somatic Mutation Accumulation, Loss of Differentiation, and Increased Transcriptional Entropy in Aged Human Lungs

  De Man R, Cala Garcia J, Adams T, Nekola F, Moss B, Waich A, Rangel R, Anderson S, Mcdonough J, Raredon M, Yan X, Rosas I, Kaminski N. Single-cell Analysis Reveals Somatic Mutation Accumulation, Loss of Differentiation, and Increased Transcriptional Entropy in Aged Human Lungs. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5278-a5278. DOI: 10.1164/ajrccm.2025.211.abstracts.a5278.

  Peer-Reviewed Original Research

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• The Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease

  Manning E, Lee S, Ashadujjaman M, De Man R, Cai Z, Adams T, Raredon M, Ramachandra A, Cavinato C, Heerdt P, Singh I, Choudhary G, Yan X, Bellini C, Tellides G, Humphrey J, Kaminski N. The Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2891-a2891. DOI: 10.1164/ajrccm.2025.211.abstracts.a2891.

  Peer-Reviewed Original Research

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• Applying Single-Cell Spatial Profiling to Assess Niches in Human Fibrotic Silica Lung

  Abu Hussein N, Adams T, Anderson S, Kramer M, Nekola F, Homer R, Najjar A, Sharma P, Rangel R, Yang L, Zhang Y, Yan X, Pertzov B, Kaminski N. Applying Single-Cell Spatial Profiling to Assess Niches in Human Fibrotic Silica Lung. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5093-a5093. DOI: 10.1164/ajrccm.2025.211.abstracts.a5093.

  Peer-Reviewed Original Research

• Applying single cell profiling to assess drug anti fibrotic properties in the human precision cut lung slice model of fibrosis

  Justet A, Mitash N, Pineda R, Adams T, Balayev A, Abu Hussein N, Ishizuka M, Kim H, Khoury J, Cala-García J, Ahangari F, Yan X, Kaminski N, Königshoff M. Applying single cell profiling to assess drug anti fibrotic properties in the human precision cut lung slice model of fibrosis. Revue Des Maladies Respiratoires 2025, 42: 223. DOI: 10.1016/j.rmr.2025.02.083.

  Peer-Reviewed Original Research

  Concepts

• Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks

  Kurbanov D, Ahangari F, Adams T, De Man R, Tang J, Carlon M, Abu Hussein N, Cortesi E, Zapata M, De Sadelaar L, Wuyts W, Vanaudenaerde B, Kaminski N, McDonough J. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l456-l462. PMID: 39970931, PMCID: PMC12169420, DOI: 10.1152/ajplung.00171.2024.

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  MeSH Keywords and Concepts