Sunil Koundal
Research ScientistDownloadHi-Res Photo
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Yale School of Medicine
1 GILBERT ST, The anlyan center, N142
NEW HAVEN, Connecticut 06519
United States
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Titles
Research Scientist
Appointments
Anesthesiology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Post Doctoral associate
- Yale School of Medicine (2020)
- PhD
- Panjab University, Biophysics (2017)
- MSc
- Delhi University, Biomedical Sciences (2010)
- BSc
- Himachal University, Biotechnology (2008)
Research
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Overview
Medical Research Interests
Magnetic Resonance Imaging; Nuclear Magnetic Resonance, Biomolecular
Public Health Interests
Aging; Biomarkers; Metabolism; Metabolomics
ORCID
0000-0003-3969-1091
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sunil Koundal's published research.
Publications Timeline
A big-picture view of Sunil Koundal's research output by year.
Research Interests
Research topics Sunil Koundal is interested in exploring.
Helene Benveniste, MD, PhD
Zachary Gursky, PhD
Burhan Ozturk, MD
Hung-Mo Lin
Nikhil S. Malvankar
Alvaro Duque, PhD
16Publications
457Citations
Magnetic Resonance Imaging
Publications
2025
Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model
Gursky Z, Khan Z, Koundal S, Bhardwaj A, Melgarejo J, Xu K, Chen X, Lin H, Gu X, Lee H, Kipnis J, Dori Y, Tannenbaum A, Santambrogio L, Benveniste H. Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model. Journal Of Clinical Investigation 2025, 135: e182555. PMID: 40663395, PMCID: PMC12404751, DOI: 10.1172/jci182555.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDeep cervical lymph nodesLymph nodesContrast-enhanced magnetic resonance imagingDynamic contrast-enhanced magnetic resonance imagingCervical lymph nodesEvidence of hydrocephalusBlood-brain barrier leakageImpaired lymphatic drainageLow-grade inflammationLymphatic drainage pathwaysCerebral homeostasisMagnetic resonance imagingDCE-MRILymphatic drainageIntracranial pressureLymphatic vesselsMeningeal lymphatic vesselsLong-term mechanical stressResonance imagingBarrier leakageRatsSolute clearanceGlymphatic influxDrainage pathwaysAge groups
2024
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin H, Van Nostrand W, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease. IScience 2024, 27: 111463. PMID: 39720539, PMCID: PMC11667077, DOI: 10.1016/j.isci.2024.111463.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2023, 3: 1603-1603. PMID: 38001312, DOI: 10.1038/s43587-023-00544-5.Peer-Reviewed Original ResearchCitationsAltmetricContinuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus
Phan D, Dahl P, Koundal S, Pedram M, Deniz E, Benveniste H, Malvankar N, Kahle K. 195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus. Neurosurgery 2023, 69: 32-32. DOI: 10.1227/neu.0000000000002375_195.Peer-Reviewed Original ResearchCitationsConceptsVentricular dilationCongenital hydrocephalusCongenital brain malformationsHuman congenital hydrocephalusCerebrospinal fluid circulationNeural stem cell proliferationCortical hypoplasiaAqueductal obstructionBrain parenchymaBrain malformationsMouse modelHydrocephalus patientsNeurogenesis resultsVentricular expansionNeural stem cell fateCSF circulationIntracranial physiologyCSF flowGenetic subtypesPrimary physiological factorCSF dynamicsCell proliferationCSFSame point mutationHydrocephalusThe choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Robert S, Reeves B, Kiziltug E, Duy P, Karimy J, Mansuri M, Marlier A, Allington G, Greenberg A, DeSpenza T, Singh A, Zeng X, Mekbib K, Kundishora A, Nelson-Williams C, Hao L, Zhang J, Lam T, Wilson R, Butler W, Diluna M, Feinberg P, Schafer D, Movahedi K, Tannenbaum A, Koundal S, Chen X, Benveniste H, Limbrick D, Schiff S, Carter B, Gunel M, Simard J, Lifton R, Alper S, Delpire E, Kahle K. The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus. Cell 2023, 186: 764-785.e21. PMID: 36803604, PMCID: PMC10069664, DOI: 10.1016/j.cell.2023.01.017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPost-infectious hydrocephalusTLR4-dependent immune responseBlood-cerebrospinal fluid barrierSmall molecule pharmacotherapyCell cross talkPharmacological immunomodulationCytokine stormNeuroimmune disordersBrain infectionDrug treatmentImmune responseAcquired hydrocephalusHydrocephalus modelChoroid plexusFluid barrierHydrocephalusEpithelial cellsCSFMulti-omics investigationsCross talkHypersecretionHemorrhagePharmacotherapyImmunomodulationPlexus
2022
Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling
Lee H, Ozturk B, Stringer MS, Koundal S, MacIntosh BJ, Rothman D, Benveniste H. Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling. NeuroImage 2022, 261: 119512. PMID: 35882269, PMCID: PMC9969358, DOI: 10.1016/j.neuroimage.2022.119512.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsWater flowBlood perfusionLow-dose isofluraneCerebral blood flowClinical translational studiesAnti-diuretic hormoneContinuous arterial spinLevels of bloodMeasurement accuracyMagnetic resonance imagingArterial spin labelingCerebrospinal fluid productionAnesthetic regimensBalanced anesthesiaCerebral ventricleContinuous arterial spin labelingIsoflurane anesthesiaKey parametersSystemic administrationVentricular CSFImmune surveillanceArterial bloodBlood flowTissue perfusionChoroid plexusCharacterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging
Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1813-1826. PMID: 35673963, PMCID: PMC9536121, DOI: 10.1177/0271678x221105668.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmall vessel diseaseCerebral small vessel diseaseT2W magnetic resonance imagesSHRSP ratsPerivascular spacesClinical relevanceMagnetic resonance imagesVessel diseaseSeverity of SVDGadoteric acidWistar-Kyoto control ratsHypertensive stroke-prone ratsStroke-prone ratsHuman post-mortem tissueT2-weighted magnetic resonance imagesMonths of ageT1-weighted imagingMagnetic resonance imagingPost-mortem tissueVivo magnetic resonance imagingPrimary endpointHyperintense lesionsProne ratsWKY ratsUnderlying pathophysiologyStudies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy
Koundal S, Gandhi S, Khushu S. Studies on metabolic alterations due to hypobaric hypoxia in serum using NMR spectroscopy. Biomarkers 2022, 27: 562-567. PMID: 35532034, DOI: 10.1080/1354750x.2022.2076152.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHypobaric hypoxiaHypobaric hypoxia equivalentSerum metabolic changesPreclinical rat modelAmino acid metabolitesHigh-altitude hypoxiaHypoxia equivalentRat modelMetabolic alterationsHealth problemsKetone bodiesMultivariate analysisAcid metabolitesAltitude hypoxiaSerum samplesEarly detectionMetabolic changesHypoxiaMetabolism of membranePresent findingsSerumAlterationsCellular bioenergeticsPresent studyEnvironmental hypoxiaPublisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2022, 2: 454-454. PMID: 37118076, DOI: 10.1038/s43587-022-00223-x.Peer-Reviewed Original ResearchAltmetric
Academic Achievements & Community Involvement
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Honors
honor Travel grant
09/17/2024Other Award American College of NeuropsychopharmacologyDetailsUnited Stateshonor Magna Cum Laude Award
05/16/2019International AwardInternational Society for Magnetic Resonance in MedicineDetailsCanada
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Mailing Address
Yale School of Medicine
1 GILBERT ST, The anlyan center, N142
NEW HAVEN, Connecticut 06519
United States