Zachary Gursky, PhD
About
Research
Publications
2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2022
Representation of prefrontal axonal efferents in the thalamic nucleus reuniens in a rodent model of fetal alcohol exposure during third trimester
Smith IF, Gursky ZH, Klintsova AY. Representation of prefrontal axonal efferents in the thalamic nucleus reuniens in a rodent model of fetal alcohol exposure during third trimester. Frontiers In Behavioral Neuroscience 2022, 16: 993601. PMID: 36160686, PMCID: PMC9493097, DOI: 10.3389/fnbeh.2022.993601.Peer-Reviewed Original ResearchMedial prefrontal cortexFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensRodent modelsNucleus reuniensBinge alcohol exposureThird-trimester exposureFetal alcohol exposurePostnatal day 4Alcohol spectrum disordersLong-Evans ratsExecutive functioningAE animalsTrimester exposureThird trimesterDisynaptic pathwayMPFC neuronsAxons synapseFemale ratsMale ratsAxon terminalsAxonal projectionsControl animalsHippocampal cellsCharacterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging
Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1813-1826. PMID: 35673963, PMCID: PMC9536121, DOI: 10.1177/0271678x221105668.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseCerebral small vessel diseaseT2W magnetic resonance imagesSHRSP ratsPerivascular spacesClinical relevanceMagnetic resonance imagesVessel diseaseSeverity of SVDGadoteric acidWistar-Kyoto control ratsHypertensive stroke-prone ratsStroke-prone ratsHuman post-mortem tissueT2-weighted magnetic resonance imagesMonths of ageT1-weighted imagingMagnetic resonance imagingPost-mortem tissueVivo magnetic resonance imagingPrimary endpointHyperintense lesionsProne ratsWKY ratsUnderlying pathophysiologyRat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult
Gursky ZH, Klintsova AY. Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult. Alcohol And Alcoholism 2022, 57: 413-420. PMID: 35258554, PMCID: PMC9270984, DOI: 10.1093/alcalc/agac008.Peer-Reviewed Original ResearchConceptsBrain growth spurtBlood alcohol concentrationPeak blood alcohol concentrationAlcohol exposureThalamic nucleus reuniensRat modelNucleus reuniensSubstantial neuron lossBinge alcohol exposureFetal alcohol spectrum disordersGestational alcohol exposureNon-neuronal cellsLife-long changesAlcohol spectrum disordersNeuron lossIntragastric intubationRat pupsThalamic damageAE groupBehavioral alterationsCell lossLow dosesPrefrontal cortexUnbiased stereological estimationGrowth spurtSustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus. Fluids And Barriers Of The CNS 2022, 19: 20. PMID: 35248089, PMCID: PMC8898469, DOI: 10.1186/s12987-022-00319-x.Peer-Reviewed Original ResearchConceptsGlymphatic transportIntracranial pressureMagnetic resonance imagingNasal cavityCribriform plateMouse modelFluid homeostasisOlfactory bulb hypoplasiaDistinct mouse modelsNormal intracranial pressureAquaporin-4 expressionKnock-out (KO) miceWild-type littermatesConditional knockout miceChronic rhinitisCommon findingSeparate cohortAQP4 expressionAQP4 polarizationKnockout miceHydrocephalusResonance imagingConclusionsThe combinationGadoteric acidBrain morphometry
2021
Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking
Gursky ZH, Klintsova AY. Changes in Representation of Thalamic Projection Neurons within Prefrontal-Thalamic-Hippocampal Circuitry in a Rat Model of Third Trimester Binge Drinking. Brain Sciences 2021, 11: 323. PMID: 33806485, PMCID: PMC8001051, DOI: 10.3390/brainsci11030323.Peer-Reviewed Original ResearchFetal alcohol spectrum disordersAlcohol exposureMedial prefrontal cortexVentral hippocampusProjection neuronsShort-term alcohol exposureLong-Evans rat pupsPrefrontal cortexBrain growth spurtThalamic projection neuronsDevelopmental alcohol exposureAlcohol spectrum disordersThalamic nucleus reuniensExecutive functioningRE neuronsNeuron lossThird trimesterThalamic connectivityRat modelRat pupsHippocampal circuitryRodent modelsBinge drinkingNucleus reuniensNeuron numberExecutive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders
Gursky ZH, Savage LM, Klintsova AY. Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders. Behavioural Brain Research 2021, 405: 113208. PMID: 33640395, PMCID: PMC8005484, DOI: 10.1016/j.bbr.2021.113208.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBehavior, AnimalBinge DrinkingCentral Nervous System DepressantsCognitive DysfunctionDisease Models, AnimalEthanolExecutive FunctionFemaleFetal Alcohol Spectrum DisordersHypothalamusMaleNerve NetPrefrontal CortexPregnancyPregnancy Trimester, ThirdRatsRats, Long-EvansThalamusConceptsExecutive functioningFetal alcohol spectrum disordersNovel object recognitionPrenatal alcohol exposureBehavioral impairmentsSpectrum disorderAlcohol spectrum disordersPrefrontal cortexObject recognitionBehavioral flexibility tasksSpontaneous alternationPlus-maze taskMedial prefrontal cortexAlcohol exposureThalamic nucleus reuniensAlcohol-exposed ratsLong-Evans rat pupsFlexibility taskReversal learningDiscrimination learningSham intubationsBehavioral alterationsDevelopmental alcoholAssociative memoryMaze task
2020
Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function
Savage LM, Nunes PT, Gursky ZH, Milbocker KA, Klintsova AY. Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function. Neuropsychology Review 2020, 31: 447-471. PMID: 32789537, PMCID: PMC7878584, DOI: 10.1007/s11065-020-09450-8.Peer-Reviewed Original ResearchConceptsAlcohol-related brain damageBrain damageAlcohol use disorderMidline thalamusAlcohol-related cognitive dysfunctionCognitive dysfunctionDistinct thalamocortical pathwaysAlcohol-related damageLoss of neuronsThalamo-cortical circuitsDevelopmental ethanol exposureBehavioral outcomesCognition functionCentral brain structuresBehavioral interventionsLimbic nucleiThalamic pathologyThalamocortical pathwaysEthanol exposureThalamic damageUse disordersAnimal modelsThalamusBrain structuresFlexible adaptationPostnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat
Gursky ZH, Johansson JR, Klintsova AY. Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat. International Journal Of Developmental Neuroscience 2020, 80: 558-571. PMID: 32681672, PMCID: PMC8246316, DOI: 10.1002/jdn.10051.Peer-Reviewed Original ResearchConceptsPostnatal alcohol exposureEarly postnatal alcohol exposureAlcohol exposureAdolescent exerciseCerebellar volumeMicroglial densityCerebellar microgliaRodent modelsAberrant cerebellar connectivityMicroglia-specific proteinsFetal alcohol spectrum disordersPotential therapeutic effectsDevelopmental alcohol exposurePostnatal day 42Female Long-EvansAlcohol spectrum disordersExercise interventionMicroglial dysfunctionNeuroimmune dysfunctionNeuroimmune cellsNeuroimmune functionVoluntary exerciseTherapeutic effectMicrogliaCerebellar connectivitySingle-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens
Gursky ZH, Spillman EC, Klintsova AY. Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens. Neuroscience 2020, 435: 124-134. PMID: 32251710, PMCID: PMC7236664, DOI: 10.1016/j.neuroscience.2020.03.046.Peer-Reviewed Original ResearchConceptsFetal alcohol spectrum disordersAlcohol exposureThalamic nucleus reuniensCell lossAlcohol administrationFemale Long-Evans rat pupsNucleus reuniensApoptotic cell deathNon-neuronal cell numbersThird trimester alcohol exposureLong-Evans rat pupsCell deathPostnatal alcohol exposureAlcohol-exposed animalsFunction of hippocampusDevelopmental alcohol exposurePostnatal day 7Evans rat pupsEarly life stressAlcohol spectrum disordersCell numberCell type-dependent mannerNeuron lossRat pupsRodent models