Sarah Slavoff
Associate Professor Tenure of Chemistry and of Molecular Biophysics and BiochemistryCards
About
Research
Publications
Featured Publications
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
Na Z, Dai X, Zheng SJ, Bryant CJ, Loh KH, Su H, Luo Y, Buhagiar AF, Cao X, Baserga SJ, Chen S, Slavoff SA. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Molecular Cell 2022, 82: 2900-2911.e7. PMID: 35905735, PMCID: PMC9662605, DOI: 10.1016/j.molcel.2022.06.035.Peer-Reviewed Original ResearchNascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor
Cao X, Khitun A, Harold CM, Bryant CJ, Zheng SJ, Baserga SJ, Slavoff SA. Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor. Nature Chemical Biology 2022, 18: 643-651. PMID: 35393574, PMCID: PMC9423127, DOI: 10.1038/s41589-022-01003-9.Peer-Reviewed Original ResearchAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
Cao X, Khitun A, Luo Y, Na Z, Phoodokmai T, Sappakhaw K, Olatunji E, Uttamapinant C, Slavoff SA. Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nature Communications 2021, 12: 508. PMID: 33479206, PMCID: PMC7820019, DOI: 10.1038/s41467-020-20841-6.Peer-Reviewed Original ResearchAlternative SplicingAmino Acid SequenceBase SequenceBiological TransportCell MembraneDown-RegulationEndoplasmic ReticulumHEK293 CellsHumansMembrane ProteinsMutationPhosphatidylinositol 3-KinasesPhosphatidylinositol 4,5-DiphosphateProtein BindingProto-Oncogene Proteins c-aktRibosomal ProteinsSignal TransductionTOR Serine-Threonine Kinases
2026
Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics
Wacholder A, Deutsch E, Kok L, van Dinter J, Lee J, Wright J, Leblanc S, Jayatissa A, Jiang K, Arefiev I, Cao K, Bourassa F, Trifiro F, Bassani-Sternberg M, Baranov P, Bogaert A, Chothani S, Fierro-Monti I, Fijalkowska D, Gevaert K, Hubner N, Mudge J, Ruiz-Orera J, Schulz J, Vizcaíno J, Prensner J, Brunet M, Martinez T, Slavoff S, Roucou X, Choudhary J, van Heesch S, Moritz R, Carvunis A. Author Correction: Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics. Nature Communications 2026, 17: 4882. PMID: 42230598, PMCID: PMC13230955, DOI: 10.1038/s41467-026-73431-3.Commentaries, Editorials and LettersExpanding the human proteome with microproteins and peptideins
Deutsch E, Kok L, Mudge J, Valls C, Jungreis I, Ruiz-Orera J, Sun Z, Kusebauch U, Fierro-Monti I, Abelin J, Alba M, Aspden J, Bandyopadhyay S, Banerjee K, Baranov P, Bazzini A, Bourassa F, Bruford E, Calviello L, Carr S, Carvunis A, Chothani S, Clauwaert J, Dean K, Faridi P, Frankish A, Goodale A, Green T, Hubner N, Ingolia N, Kellis M, Magrane M, Martin M, Martinez T, Menschaert G, Ohler U, Orchard S, Potter A, Rackham O, Rees M, Root D, Roth J, Roucou X, Sialana F, Slavoff S, Świrski M, Tierney J, Trifiro F, Valen E, Vasylieva V, Wacholder A, Wang S, Wang L, Weissman J, Wu W, Xie Z, Choudhary J, Bassani-Sternberg M, Vizcaíno J, Ternette N, Brunet M, Moritz R, Prensner J, van Heesch S. Expanding the human proteome with microproteins and peptideins. Nature 2026, 654: 813-825. PMID: 42092140, PMCID: PMC13275300, DOI: 10.1038/s41586-026-10459-x.Peer-Reviewed Original ResearchAn expanded reference catalog of translated open reading frames for biomedical research
Chothani S, Ruiz-Orera J, Tierney J, Swirski M, Tjeldnes H, Kok L, Clauwaert J, Deutsch E, Alba M, Aspden J, Baranov P, Bazzini A, Bruford E, Brunet M, Cardon T, Carvunis A, Casola C, Choudhary J, Dean K, Faridi P, Fierro-Monti I, Fournier I, Frankish A, Gerstein M, Hubner N, Jiang Y, Kellis M, Martinez T, Menschaert G, Ni P, Orchard S, Roucou X, Rozowsky J, Salzet M, Siragusa M, Slavoff S, Ternette N, Vizcaino J, Wacholder A, Wu W, Xie Z, Yang Y, Moritz R, Valen E, Mudge J, van Heesch S, Prensner J, Rackham O. An expanded reference catalog of translated open reading frames for biomedical research. Nucleic Acids Research 2026, 54: gkag234. PMID: 41873765, PMCID: PMC13010147, DOI: 10.1093/nar/gkag234.Peer-Reviewed Original ResearchCommunity benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics
Wacholder A, Deutsch E, Kok L, van Dinter J, Lee J, Wright J, Leblanc S, Jayatissa A, Jiang K, Arefiev I, Cao K, Bourassa F, Trifiro F, Bassani-Sternberg M, Baranov P, Bogaert A, Chothani S, Fierro-Monti I, Fijalkowska D, Gevaert K, Hubner N, Mudge J, Ruiz-Orera J, Schulz J, Vizcaíno J, Prensner J, Brunet M, Martinez T, Slavoff S, Roucou X, Choudhary J, van Heesch S, Moritz R, Carvunis A. Community benchmarking and evaluation of human unannotated microprotein detection by mass spectrometry based proteomics. Nature Communications 2026, 17: 1241. PMID: 41559053, PMCID: PMC12865046, DOI: 10.1038/s41467-025-68002-x.Peer-Reviewed Original Research
2025
Translon: a single term for translated regions
Świrski M, Tierney J, Albà M, Andreev D, Aspden J, Atkins J, Bassani-Sternberg M, Berry M, Biffo S, Boris-Lawrie K, Borodovsky M, Brierley I, Brook M, Brunet M, Bujnicki J, Caliskan N, Calviello L, Carvunis A, Cate J, Cenik C, Chang K, Chen Y, Chothani S, Choudhary J, Clark P, Clauwaert J, Cooley L, Dassi E, Dean K, Diaz J, Dieterich C, Dikstein R, Dinman J, Dmitriev S, Dontsova O, Dunham C, Eswarappa S, Farabaugh P, Faridi P, Fierro-Monti I, Firth A, Gatfield D, Gebauer F, Gelfand M, Gray N, Green R, Hill C, Hou Y, Hübner N, Ignatova Z, Ivanov P, Iwasaki S, Johnson R, Jomaa A, Jovanovic M, Jungreis I, Kellis M, Kieft J, Kochetov A, Koonin E, Korostelev A, Kufel J, Kulakovskiy I, Kurian L, Lafontaine D, Larsson O, Loughran G, Lukeš J, Mariotti M, Martens-Uzunova E, Martinez T, Matsumoto A, McManus J, Medenbach J, Melnikov S, Menschaert G, Merchante C, Mikl M, Miller W, Mühlemann O, Namy O, Nedialkova D, Nosek J, Orchard S, Ozretić P, Pertea M, Pervouchine D, Romão L, Ron D, Roucou X, Rubtsova M, Ruiz-Orera J, Saghatelian A, Salzberg S, Seale L, Seoighe C, Sergiev P, Shah P, Shirokikh N, Slavoff S, Sonenberg N, Stasevich T, Szczesny R, Tamm T, Tchórzewski M, Topisirovic I, Tremblay M, Tuller T, Ulitsky I, Valášek L, Van Damme P, Viero G, Vizcaino J, Vogel C, Wallace E, Weissman J, Westhof E, Whiffin N, Wilson D, Xie Z, Yewdell J, Yordanova M, Yu C, Yurchenko V, Zagrovic B, Valen E, Baranov P. Translon: a single term for translated regions. Nature Methods 2025, 22: 2002-2006. PMID: 40890551, DOI: 10.1038/s41592-025-02810-3.Commentaries, Editorials and LettersLZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis
Bacchiocchi A, Mak M, Khan Z, Gong X, Sznol M, Na Z, Su H, Chan L, Yan Q, Zhao D, Mortlock R, Knight J, Slavoff S, Halaban R. LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis. Oncogene 2025, 44: 3974-3984. PMID: 40885854, PMCID: PMC12500468, DOI: 10.1038/s41388-025-03538-2.Peer-Reviewed Original ResearchThe ERVK3‑1 Microprotein Interacts with the HUSH Complex
Jayatissa A, Jaunbocus N, Erkalo B, Jiang K, Zheng S, Su H, Yan L, Choi J, Vaughan J, Bacchiocchi A, Na Z, Cao X, Halaban R, Saghatelian A, Craft J, Chen Y, Slavoff S. The ERVK3‑1 Microprotein Interacts with the HUSH Complex. Biochemistry 2025, 64: 3372-3381. PMID: 40699144, PMCID: PMC12339190, DOI: 10.1021/acs.biochem.5c00023.Peer-Reviewed Original Research