Ken Huaijin Loh, PhD, BSc

Assistant Professor in Comparative Medicine

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Appointments

Comparative Medicine

Primary

Contact Info

Yale University

PO Box 27391

West Haven, CT 06516-7392

United States

About

Titles

Assistant Professor in Comparative Medicine

Biography

Ken Loh is an Assistant Professor in the Department of Comparative Medicine in the Institute for Biomolecular Design and Discovery at Yale University’s West Campus. A native of Singapore, he received his B.S. in Chemistry from Harvey Mudd College in 2009 and earned his Ph.D in Chemistry with Alice Ting at MIT in 2016, developing chemical-enzymatic methodologies for tagging proteins in cells. Ken next received postdoctoral training with Jeffrey Friedman at Rockefeller University, studying the role of leptin in its regulation of sympathetic nerves in the fat organ, and joined the faculty at Yale in August of 2022. His lab is interested in studying brain-body interactions at a molecular length scale, using tools in chemical biology.

Last Updated on January 30, 2023.

Appointments

Comparative Medicine
Assistant Professor
Primary
Comparative Medicine

Education & Training

NIH Pathway to Independence K99 Fellow: The Rockefeller University (2022)

Helen Hay Whitney Postdoctoral Fellow: The Rockefeller University (2021)

PhD: Massachusetts Institute of Technology, Chemistry (2016)

BSc: Harvey Mudd College, Chemistry (2009)

Research

Overview

Medical Research Interests

Autonomic Nervous System; Biochemistry; Diabetes Mellitus; Neurobiology; Obesity; Peripheral Nervous System; Proteomics; Synapses

Public Health Interests

Metabolism

ORCID
0000-0002-2901-0750
Loh Laboratory
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Ken Huaijin Loh's published research.

Boby Mathew
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Sarah Slavoff
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Antonella Bacchiocchi
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Christian Felipe Ruiz, PhD
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Daniel McQuaid
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Jeremy B. Jacox, MD, PhD
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Publications

2026

Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling
Plucińska K, Wayne C, Sanford H, Mathew B, Ropek N, Adaniya S, Model C, Gómez-Banoy N, Morozova K, Cao X, Friedman J, Loh K, Cohen P, Vinogradova E. Cell-type-specific proximity labeling of organ secretomes reveals energy balance-dependent proteomic remodeling. Cell Reports 2026, 45: 117507. PMID: 42284144, DOI: 10.1016/j.celrep.2026.117507.
Peer-Reviewed Original Research
MeSH Keywords
Controlling distance, time and reactivity: Chemical principles of proximity labeling
Ruenkam T, Wang Z, Juvekar V, Loh K. Controlling distance, time and reactivity: Chemical principles of proximity labeling. Current Opinion In Chemical Biology 2026, 93: 102705. PMID: 42284692, PMCID: PMC13267857, DOI: 10.1016/j.cbpa.2026.102705.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
Garcia C, Venkat A, McQuaid D, Agabiti S, Tong A, Mathew B, Cardone R, Starble R, Ruiz C, Zheng C, Sogunro A, Jacox J, Loh K, Kibbey R, Krishnaswamy S, Muzumdar M. Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development. Nature Communications 2026, 17: 3292. PMID: 41760660, PMCID: PMC13066563, DOI: 10.1038/s41467-026-69821-2.
Peer-Reviewed Original Research
This study investigates how obesity-induced cholecystokinin (CCK) expression in pancreatic beta cells drives pancreatic cancer development by altering cellular signaling within the environment of arising tumors, suggesting potential therapeutic targets.
Full Summary

2017

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons
Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Systems 2017, 4: 242-250.e4. PMID: 28131823, PMCID: PMC5578869, DOI: 10.1016/j.cels.2017.01.002.
Peer-Reviewed Original Research

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Academic Achievements & Community Involvement

Honors

honor
2025 Collaborative Sciences Award
04/01/2025National AwardAmerican Heart Association
Details
honor
2024 ORAU Ralph E. Powe Junior Faculty Enhancement Award
05/29/2024National AwardORAU
Details
honor
Klingenstein-Simons Fellowship Award in Neuroscience
07/01/2023National AwardEsther A. & Joseph Klingenstein Fund
honor
NIH Pathway to Independence Award K99/R00
08/11/2021National AwardNIH/NIDDK
honor
Helen Hay Whitney Postdoctoral Fellowship
04/01/2018National AwardHelen Hay Whitney Foundation

Teaching & Mentoring

Mentoring

Rebecca Schelling
Graduate student
2024 - Present
Angela To
Graduate student
2024 - Present
Zhongjie Wang
Postdoc
2024 - Present
Vinayak Juvekar
Associate Research Scientist
2024 - Present

Willing and Available to Mentor
- Students

News

Get In Touch

Contacts

Mailing Address

Yale University

PO Box 27391

West Haven, CT 06516-7392

United States

Administrative Support

Laura Miller
Senior Administrative Assistant; Senior Administrator (Cardiology)

Locations

Institute of Biomolecular Design and Discovery
Academic Office
West Campus Molecular Innovations Center
600 West Campus Drive, Rm 312D
West Haven, CT 06516
Business Office
203.737.3870
Get Directions

Events

Oct 20265Monday

Yale Only
8:45 AM5:15 PM
Ken Huaijin Loh, PhD, BSc - Tamas Horvath, DVM, PhD - Juan Uribe Isaza - Maryann Platt - Jane Rebecca Taylor, PhD - Marc Claret - Marcela Carmona - Nicolas Renier - Priya Rajasaetupathy - Sho Aoki - Paul Muller - Anoj Ilanges
Yale and the World Symposium
Sponsored by Wu Tsai Institute, Cellular & Molecular Physiology, and Office of International Affairs
Sterling Hall of Medicine, B-Wing
Zoom link available for those who cannot attend in person.
https://yale.zoom.us/j/91398772020
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Appointments

Contact Info

Titles

Biography

Appointments

Comparative Medicine

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

Public Health Interests

ORCID

Loh Laboratory

Research at a Glance

Yale Co-Authors

Boby Mathew

Sarah Slavoff

Antonella Bacchiocchi

Christian Felipe Ruiz, PhD

Daniel McQuaid

Jeremy B. Jacox, MD, PhD

Publications

2026

2025

2023

2022

2020

2017

Honors

2025 Collaborative Sciences Award

2024 ORAU Ralph E. Powe Junior Faculty Enhancement Award

Klingenstein-Simons Fellowship Award in Neuroscience

NIH Pathway to Independence Award K99/R00

Helen Hay Whitney Postdoctoral Fellowship

Mentoring

Rebecca Schelling

Angela To

Zhongjie Wang

Vinayak Juvekar

Willing and Available to Mentor

News

Women’s Health Research at Yale Funds Projects on Obesity and Ovarian Aging, Diabetes, Cancers, and Autoimmunity

Grants Awarded at YCC • 2024

Contacts

Administrative Support

Locations

Institute of Biomolecular Design and Discovery

Events

Yale and the World Symposium