Qin Li, MD
Associate Research ScientistCards
About
Research
Publications
2023
A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma
Chen Z, Ge L, Xu S, Li Q, Zhou L. A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma. Scientific Reports 2023, 13: 9921. PMID: 37337018, PMCID: PMC10279685, DOI: 10.1038/s41598-023-36720-1.Peer-Reviewed Original ResearchConceptsPyroptosis-related genesTumor-infiltrating immune cellsTumor mutational burdenLung adenocarcinomaImmune cellsMutational burdenPrognostic signaturePyroptosis-related gene signatureTumor microenvironmentGene Expression Omnibus (GEO) cohortSelection operator CoxImmune cell infiltrationRole of pyroptosisIndependent prognostic biomarkerTumor immune microenvironmentCox regression modelImmune checkpoint regulatorsCancer-related deathCancer Genome Atlas (TCGA) databaseSpearman correlation analysisFuture studiesImmune microenvironmentCell infiltrationLUAD patientsCommon causeIntegrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer
Chen Z, Yu F, Zhu B, Li Q, Yu Y, Zong F, Liu W, Zhang M, Wu S. Integrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer. Medicine 2023, 102: e33192. PMID: 36897674, PMCID: PMC9997791, DOI: 10.1097/md.0000000000033192.Peer-Reviewed Original ResearchConceptsMRNA ceRNA networkEndogenous RNA (ceRNA) networkCeRNA networkMessenger RNAsRNA networkLncRNA-miRNACompetitive endogenous RNA (ceRNA) networkLong non-coding RNAsPotential ceRNA networksNon-coding RNAsFunctions of DEmRNAsCancer-related processesCancer Genome AtlasGenome analysisGene OntologyKyoto EncyclopediaDevelopment of NSCLCGene Expression Omnibus (GEO) cohortNovel insightsGenome AtlasSurvival packageExpression levelsIntegrated analysisDEmRNAsMiRNAs
2022
A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms
Ma R, Wang X, Li Q, Cai H, Luo X. A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms. Journal Of Helminthology 2022, 96: e90. PMID: 36573372, DOI: 10.1017/s0022149x22000773.Peer-Reviewed Original Research
2021
An update: the emerging evidence of complement involvement in COVID-19
Li Q, Chen Z. An update: the emerging evidence of complement involvement in COVID-19. Medical Microbiology And Immunology 2021, 210: 101-109. PMID: 33811541, PMCID: PMC8019074, DOI: 10.1007/s00430-021-00704-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeCOVID-19 patientsCOVID-19Pre-clinical samplesRespiratory distress syndromePotential treatment optionCoronavirus disease 2019Host immune responseMultiorgan failureComplement involvementSystemic inflammationDistress syndromeSevere patientsOrgan damageKidney failureTreatment optionsInflammatory responseTissue injuryDisease 2019Immune responseAnimal modelsMultiple organsAbnormal activationInnate immunityComplement inhibitorsLong noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state
Omote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.Peer-Reviewed Original ResearchConceptsTerminal differentiation-induced lncRNANormal human bronchial epithelial cellsTINCR overexpressionCell differentiationNotch genesTissue developmentBronchial epithelial cellsExtracellular matrix organizationCell phenotypeRNA sequencing analysisNumerous biological functionsRole of lncRNAsCell differentiation stateEpithelial cellsHuman bronchial epithelial cellsCiliated cell differentiationStaufen1 proteinNovel regulatorBasal cell phenotypeDownstream regulatorsRNA immunoprecipitationBiological functionsCritical regulatorDifferential expressionDifferentiation state
2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDeliveryCorrection to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. Correction to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 560. PMID: 32736603, PMCID: PMC7395387, DOI: 10.1186/s12879-020-05300-3.Peer-Reviewed Original ResearchA pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 525. PMID: 32689953, PMCID: PMC7372874, DOI: 10.1186/s12879-020-05250-w.Peer-Reviewed Original ResearchConceptsLoop-mediated isothermal amplificationBacterial meningitisFunnel plotPublication biasHigh mortality rateLAMP assayWeb of ScienceSROC curvePooled analysisMortality rateClinical practiceDiagnostic accuracyMajor causeMeningococcusNeisseria meningitidisSummary receiverCharacteristic curveMeningitisReliable diagnosisDeeks' funnel plotIsothermal amplificationDepressed areasOriginal studyMeningitidisBacterial culturePooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis
Chen YZ, Sun LC, Wen YH, Li ZW, Fan SJ, Tan HK, Qiu M, Pan ZY, Li Q, Zhao YZ, Li ZX, Guo XG. Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis. Bioscience Reports 2020, 40: bsr20191312. PMID: 31778149, PMCID: PMC6946622, DOI: 10.1042/bsr20191312.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFMTB/RIFTuberculous meningitisPositive likelihood ratioNegative likelihood ratioDiagnostic odds ratioOdds ratioEarly diagnosisCerebrospinal fluidCSF samplesPooled sensitivityLikelihood ratioReceiver operator characteristic curveOverall pooled sensitivityOperator characteristic curveExtrapulmonary tuberculosisDiagnostic delayPooled analysisSummary receiver operator characteristic curveDiagnostic efficacyClinical diagnosisMeningitisPooled specificityRelevant studiesDiagnosis
2019
Transcriptional regulatory model of fibrosis progression in the human lung
McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAdvanced fibrosisAlveolar surface densityFibrosis progressionLung fibrosisHuman lungDynamic Regulatory Events MinerExtent of fibrosisIPF lungsPulmonary fibrosisControl lungsIPF tissueB lymphocytesFibrosisLungLinear mixed-effects modelsMixed-effects modelsGene expression changesSystems biology modelsDifferential gene expression analysisGene expression analysisProgressionGene expression networksRNA sequencingBiology models
News
News
- November 28, 2023
Yale Cancer Center Experts Present New Research at Hematology Annual Meeting
- July 27, 2022
New Appointments & Promotions Within Department of Internal Medicine
- April 15, 2020
Dr. Qin Li Orchestrates Donation of PPE for Yale-PCCSM
- November 18, 2019Source: Pulmonary Fibrosis News
Model of Pulmonary Fibrosis Details Gene Changes at Specific Disease Stages, Study Reports