Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMiriam Treggiari, MD, PhD, MPH
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Titles
Professor Adjunct
Vice Chair of Clinical Research, Anesthesiology
Biography
Dr. Miriam Treggiari is Professor and Vice Chair of Clinical Research in the Department of Anesthesiology at the Yale School of Medicine. Before joining Yale, she was Endowed Professor and Vice Chair for Research at the Oregon Health and Science University. She is an internationally recognized leader in the area of clinical and outcomes research in the perioperative setting with special emphasis in critically ill and neurocritical care patients.
Dr. Treggiari received her medical training in Italy and Switzerland. Following her anesthesiology residency, she completed a fellowship in Critical Care Medicine at the Geneva University Hospital, Switzerland. She earned an MPH in Epidemiology at the University of Washington, School of Public Health and Community Medicine. In 2007, she completed a PhD in Epidemiology at the University of Washington.
Last Updated on April 07, 2025.
Appointments
Education & Training
- PhD
- University of Washington, Epidemiology (2007)
- MPH
- University of Washington, Epidemiology (2002)
- Fellow
- Geneva University Hospitals (1998)
- Resident
- Geneva University Hospitals (1997)
- MD
- University of Pavia (1990)
Research
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Overview
Medical Research Interests
Anesthesiology; Critical Care; Epidemiology; Perioperative Care
ORCID
0000-0003-4639-3682
Research at a Glance
Yale Co-Authors
Frequent collaborators of Miriam Treggiari's published research.
Publications Timeline
A big-picture view of Miriam Treggiari's research output by year.
Research Interests
Research topics Miriam Treggiari is interested in exploring.
Hung-Mo Lin
Jinlei Li, MD, PhD
Emily Sharp, PhD, ABPP
Amit Bardia, MD
Christopher Tormey, MD
Clark Fisher, MD, PhD
162Publications
7,312Citations
Critical Care
Perioperative Care
Anesthesiology
Publications
2026
Antibiotic De-escalation and 30-day mortality in patients with suspected bacterial culture-negative Sepsis
Ohnuma T, Fuller M, Balamurugan P, Moehring R, Krishnamoorthy V, Raghunathan K, Treggiari M. Antibiotic De-escalation and 30-day mortality in patients with suspected bacterial culture-negative Sepsis. Journal Of Critical Care 2026, 95: 155646. PMID: 42224805, DOI: 10.1016/j.jcrc.2026.155646.Peer-Reviewed Original ResearchConceptsAntibiotic de-escalationCulture-negative sepsisAssociated with 30-day mortalityRetrospective cohort studyDe-EscalationCohort study of adult patientsRetrospective cohort study of adult patientsStudy of adult patientsSOFA score changesAnti-MRSA antibioticsCrude 30-day mortality rateNegative bacterial culturesDays of onsetMultivariate regression analysisSeverity of illnessCommunity-onset sepsisAntibiotic changeSOFA scoreAdult patientsDay 1SepsisAntimicrobial stewardshipDay 3PatientsInclusion criteriaGlucocorticoid-Enhanced Fascial Plane and Peripheral Nerve Blocks Versus Periarticular and Local Infiltration Analgesia in Total Hip Arthroplasty: A Prospective Randomized Controlled Trial.
Li J, Rubin L, Krishnan R, Blessing M, Townsend D, Tung W, Zhao X, Treggiari M, He Z, Dai F, Lin H, Leslie M. Glucocorticoid-Enhanced Fascial Plane and Peripheral Nerve Blocks Versus Periarticular and Local Infiltration Analgesia in Total Hip Arthroplasty: A Prospective Randomized Controlled Trial. Journal Of Bone And Joint Surgery-American Volume 2026 PMID: 42127167, DOI: 10.2106/jbjs.25.01476.Peer-Reviewed Original ResearchConceptsOral morphine milligram equivalentsLateral femoral cutaneous nerve blockAnterior quadratus lumborum blockPostoperative day 1Postoperative dayLocal infiltration analgesiaBrief Pain InventoryOpioid consumptionDexamethasone sodium phosphatePatient-Reported Outcomes Measurement Information SystemMethylprednisolone acetateNo significant differenceInfiltration analgesiaPrimary outcomeSecondary outcomesProspective randomized controlled trialsSerum glucoseWhite blood-cell countDaily opioid consumptionTotal hip arthroplastyMorphine Milligram EquivalentsDescription of levels of evidencePostoperative day 2Significant differenceFasting serum glucoseStepwise clinical and diagnostic strategy for coma of unknown origin
Silva S, Treggiari M, Citerio G, Stevens R, De Lucia M, Newcombe V, Thibaut A, Weiss N, Sonneville R. Stepwise clinical and diagnostic strategy for coma of unknown origin. Intensive Care Medicine 2026, 52: 729-746. PMID: 42059919, PMCID: PMC13221429, DOI: 10.1007/s00134-026-08418-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPathophysiology of comaEvaluation of comaTreatable etiologiesDiagnostic challengeClinical outcomesBrain systemsClinical examinationAdvanced MRIDiagnostic strategiesBrain dysfunctionDiagnostic algorithmPersonalized managementLaboratory investigationsEarly decision-makingComaDiagnosisConsciousness frameworkAcute-care settingAssociation of blood pressure variability with clinical and biomarker outcomes in moderate to severe TBI: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Kulkarni A, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V. Association of blood pressure variability with clinical and biomarker outcomes in moderate to severe TBI: A TRACK-TBI study. Journal Of Clinical Neuroscience 2026, 149: 111994. PMID: 41915974, DOI: 10.1016/j.jocn.2026.111994.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBlood pressure variabilityIn-Hospital MortalityBrain injury biomarkersAverage real variabilityDisability Rating ScaleInjury biomarkersTraumatic brain injuryPrognostic valueSurrogate markerAssociation of blood pressure variabilitySecondary outcomesAssociated with higher hs-CRP levelsHigher hs-CRP levelsMarker of autonomic dysfunctionBPV metricsPrognostic value of blood pressure variabilityOdds of in-hospital mortalityHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyTransforming clinical researchModerate to severe traumatic brain injuryModerate-to-severe TBIPressure variabilityTRACK-TBI861: ANTIBIOTIC DE-ESCALATION AND 30-DAY MORTALITY IN CULTURE-NEGATIVE SEPSIS
Ohnuma T, Fuller M, Balamurugan P, Krishnamoorthy V, Raghunathan K, Treggiari M. 861: ANTIBIOTIC DE-ESCALATION AND 30-DAY MORTALITY IN CULTURE-NEGATIVE SEPSIS. Critical Care Medicine 2026, 54 DOI: 10.1097/01.ccm.0001185440.81983.b1.Peer-Reviewed Original Research20: THE ROLE OF BLOOD-BRAIN BARRIER DYSFUNCTION IN INTENSIVE CARE UNIT DELIRIUM
Popowicz P, Takla J, Timko N, Bennett M, Adams M, Simon J, Serbanescu M, Elebasy M, Hassan R, Muehlbauer M, Bain J, Hsia B, Chand S, Monten K, Teshome S, Al-Qudsi O, Mendelson B, Sasannejad C, Treggiari M, Devinney M. 20: THE ROLE OF BLOOD-BRAIN BARRIER DYSFUNCTION IN INTENSIVE CARE UNIT DELIRIUM. Critical Care Medicine 2026, 54 DOI: 10.1097/01.ccm.0001182272.48754.4c.Peer-Reviewed Original ResearchInternational Position Paper on Outcome Selection After Aneurysmal Subarachnoid Hemorrhage
Andersen C, Fernie G, Presseau J, Shea B, Marti M, Hostettler I, Rahmani R, Iona T, English S, McIntyre L, Delaney A, Chassé M, Saigle V, McCoy M, Marshall S, Fergusson D, Graham I, Brehaut J, Turgeon A, Lauzier F, Tugwell P, Zha X, Talbot P, Muscedere J, Marshall J, Thavorn K, Griesdale D, Clouthier R, Fitzgerald E, Haines J, Porteous R, Tuttle A, Jahromi B, May S, Ng V, Christenson M, Buckley C, Galea I, Nicholson M, Amin-Hanjani S, Treggiari M, Abdulazim A, Hugelshofer M, Suarez J, Houlton J, Chou S, Chen P, Cuadrado-Godia E, Donaldson L, Saliterman M, Smart A, Miller L, Nelson S, Farnsworth S, Mayer S, Hasan D, Dreier J, Bhagat H, Chandra R, Owens L, Busl K, Vergouwen M. International Position Paper on Outcome Selection After Aneurysmal Subarachnoid Hemorrhage. Stroke 2026, 57: 560-567. PMID: 41498145, PMCID: PMC12829493, DOI: 10.1161/strokeaha.125.053470.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAltmetricMeSH Keywords and ConceptsConceptsHealth-related qualityHealth-related quality of lifeDomains of healthCore Domain SetMultidisciplinary working groupQuality of lifePrioritization surveyHealth outcomesHealth researchOutcome selectionInternational multidisciplinary working groupConsensus processConsensus meetingPosition statementInternational position statementsHealthConsensus methodologyResearch leadersAneurysmal subarachnoid hemorrhageFunctional outcomesConsensus definitionInternational position papersWorking GroupDomain settingOutcomes
2025
Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial
Treggiari M, Sharp E, Ohnuma T, Fajardo E, Aydin A, Akhtar S, Kampp M, Hashemaghaie M, Potnis A, Gugel T, Simon J, Curry L, Adams K, Darji B, Sureshanand S, Hintz R, Lorzano S, Johnson C, Yanez N. Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial. The Lancet Respiratory Medicine 2025, 14: 141-150. PMID: 41319662, PMCID: PMC12858053, DOI: 10.1016/s2213-2600(25)00294-2.Peer-Reviewed Original ResearchThis study investigates the long-term safety and efficacy of polyurethane-cuffed endotracheal tubes with subglottic suction in emergency intubation, showing no reduction in ventilator-associated pnemonia or improvement in patient outcomes, suggesting potential laryngeal injury risks.A Randomized Controlled Trial of Intrathecal 1% Chloroprocaine Versus 0.75% Hyperbaric Bupivacaine for Short Obstetric Procedures
Togioka B, Tekkali P, Ye S, Rakshe S, Yanez D, Treggiari M. A Randomized Controlled Trial of Intrathecal 1% Chloroprocaine Versus 0.75% Hyperbaric Bupivacaine for Short Obstetric Procedures. Cureus 2025, 17: e97173. PMID: 41426866, PMCID: PMC12714325, DOI: 10.7759/cureus.97173.Peer-Reviewed Original ResearchConceptsExternal cephalic versionTransvaginal cerclage placementPostpartum bilateral tubal ligationCephalic versionBilateral tubal ligationDuration of motor blockCerclage placementTubal ligation surgeryObstetric proceduresBladder catheterizationRandomized Controlled TrialsDischarge readinessKnee flexionMotor blockTubal ligationLigation surgeryHyperbaric bupivacaineMethods Single-centerPostanesthesia care unit dischargePrimary endpointSecondary endpointsSingle-centerSpinal anesthesiaIntrathecal bupivacaineSpinal failureEarly Use of Cryoprecipitate Versus Plasma and Clinical Outcomes in Major Spine Surgery
Depuru A, La J, Treggiari M, Guinn N. Early Use of Cryoprecipitate Versus Plasma and Clinical Outcomes in Major Spine Surgery. Journal Of Clinical Medicine 2025, 14: 7441. PMID: 41156308, PMCID: PMC12564965, DOI: 10.3390/jcm14207441.Peer-Reviewed Original ResearchConceptsPacked red blood cellsTotal blood productsSpine surgeryCryoprecipitate groupOne-year mortalityBlood productsICU-LOSLength of stayBlood lossPostoperative dayH-LOSHospital lengthICU lengthMajor spine surgeryBlood product transfusionHospital length of stayICU length of stayTreatment of coagulopathyRetrospective cohort studyAssociated with higher oddsDischarged to homeProduct transfusionAdult patientsClinical outcomesRed blood cells
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