Marc David Normandin, PhD
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation
Borchers L, Dan R, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, El Fakhri G, Normandin M, Pizzagalli D. Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation. Molecular Psychiatry 2025, 1-9. PMID: 40926089, DOI: 10.1038/s41380-025-03218-3.Peer-Reviewed Original ResearchResting-state functional connectivityMajor depressive disorderChildhood sexual abuseDopamine transporter availabilityDepressive disorderPathophysiology of Major Depressive DisorderStriatal dopamine transporter availabilitySexual abuseReward-related regionsSeed-based RSFCVentral tegmental areaDA dysregulationVentral striatumMDD episodeTegmental areaFrontostriatal pathwaysUnmedicated individualsChildhood maltreatmentNeuroimaging investigationsFunctional connectivityTransporter availabilityTreatment targetMRI studiesAbuseCo-occurrenceIn vivo 3D myocardial membrane potential mapping in humans using PET/MRI
Bijari F, Han P, Marin T, Lee W, Chemli Y, Gertsenshteyn I, Mounime I, Djebra Y, Chi D, Normandin M, Ma C, Fakhri G. In vivo 3D myocardial membrane potential mapping in humans using PET/MRI. EJNMMI Research 2025, 15: 93. PMID: 40715686, PMCID: PMC12297085, DOI: 10.1186/s13550-025-01287-7.Peer-Reviewed Original ResearchMembrane potentialExtracellular volume fraction measurementsExtracellular volume fraction mappingBolus-plus-infusion protocolT1 mapping sequencesVolume of distributionWritten Informed ConsentCardiac PET/MR imagingRigid image registrationHumans in vivoContrast agent injectionPET motion correctionFree breathingTracer volume of distributionImage registrationBolus injectionCardiac MRMitochondrial membrane potentialCardiac diseaseHealthy subjectsPET/MR imagingImaging studiesTreatment monitoringAgent injectionPET tracersQuantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240.
Xia Y, Dhaynaut M, Chemli Y, Lois C, Hanseeuw B, Thibault E, Groot C, Ossenkoppele R, Johnson K, El Fakhri G, Normandin M, Guehl N. Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [18F]MK6240. Journal Of Nuclear Medicine 2025, 66: 1299-1306. PMID: 40533354, PMCID: PMC12320581, DOI: 10.2967/jnumed.125.270165.Peer-Reviewed Original Research3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy
Jee K, Bijari F, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kang J, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G. 3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy. Radiotherapy And Oncology 2025, 206: s3543-s3544. DOI: 10.1016/s0167-8140(25)01927-9.Peer-Reviewed Original Research273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation
Dan R, Borchers L, Belleau E, Kaiser R, Clegg R, Goer F, Pechtel P, Beltzer M, Wooten D, Fakhri G, Normandin M, Pizzagalli D. 273. Dopaminergic Frontostriatal Pathways in Major Depressive Disorder and Childhood Sexual Abuse: A Multimodal Neuroimaging Investigation. Biological Psychiatry 2025, 97: s208. DOI: 10.1016/j.biopsych.2025.02.511.Peer-Reviewed Original ResearchPO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY
Kang J, Bijari F, Jee K, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Fakhri G, Levine R, Lehmann H. PO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY. Heart Rhythm 2025, 22: s484. DOI: 10.1016/j.hrthm.2025.03.1230.Peer-Reviewed Original ResearchPET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET Mapping of Receptor Occupancy Using Joint Direct Parametric Reconstruction. IEEE Transactions On Biomedical Engineering 2025, 72: 1057-1066. PMID: 39446540, PMCID: PMC11875991, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugsSelective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils
Lee S, Pearson T, Dhaynaut M, MacDonagh A, Wey H, Wilks M, Roth B, Hooker J, Normandin M. Selective Mu-Opioid Receptor Imaging Using 18F‑Labeled Carfentanils. Journal Of Medicinal Chemistry 2025, 68: 1632-1644. PMID: 39772615, DOI: 10.1021/acs.jmedchem.4c02287.Peer-Reviewed Original ResearchConceptsMu-opioid receptorsPositron emission tomographyIn vivo PET scansCarbon-11Neurobiological studiesCopper-mediated radiofluorinationMu-opioidReceptor imagingPET scansBrain uptakeFavorable pharmacokineticsImaging evaluationHigh molar activityMass doseEmission tomographyHalf-life of fluorine-18Synthetic opioidsFluorine-18Half-lifeIn vitro binding assaysBinding assaysClinical research useMolar activityCarfentanilResearch use
2024
Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner
Chemli Y, Marin T, Orehar M, Dolenec R, Normandin M, Gascón D, Gola A, Grogg K, Pavón G, Razdevsek G, Pestotnik R, Fakhri G. Integration of a continuously varying image-space PSF for a dual-panel ultra-high TOF-PET scanner. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10656225.Peer-Reviewed Original ResearchGaussian mixture modelGaussian process regressionPoint spread functionAccurate image reconstructionMaximum likelihood estimation maximizationShift-variant convolutionsImage reconstructionMixture modelProcess regressionEstimation maximizationTime-of-flight (TOFPanel architectureSpread functionArchitectureParameter interpolationHigh resolution time-of-flight (TOFTOF-PET scannerBrain phantomFitting processPositron emission tomography scannerSimulated point sourcesConvolutionAlgorithmEffective diagnosisSize benefitsDeciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics
Hong J, Bae S, Cavinato L, Seifert R, Ryhiner M, Rominger A, Erlandsson K, Wilks M, Normandin M, El-Fakhri G, Choi H, Shi K. Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics. Theranostics 2024, 14: 7122-7139. PMID: 39629134, PMCID: PMC11610134, DOI: 10.7150/thno.99516.Peer-Reviewed Original Research
News
News
Get In Touch
Contacts
Academic Office Number
Mailing Addresses
Yale University
801 Howard Avenue, PO Box 208048
New Haven, CT 06520
United States
Yale University
100 Church Street South, Room D127
New Haven, CT 06519
United States
Locations
100 Church Street South
Academic Office
Ste D, Rm 127
New Haven, CT 06519
801 Howard Avenue
Lab
New Haven, CT 06519