Luke Brown, PhD
Postdoctoral AssociateAbout
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Featured Publications
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
Granton E, Brown L, Defaye M, Moazen P, Almblad H, Randall T, Rich J, Geppert A, Abdullah N, Hassanabad M, Hiroki C, Farias R, Nguyen A, Schubert C, Lou Y, Andonegui G, Iftinca M, Raju D, Vargas M, Howell P, Füzesi T, Bains J, Kurrasch D, Harrison J, Altier C, Yipp B. Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection. Cell 2024, 187: 1874-1888.e14. PMID: 38518773, DOI: 10.1016/j.cell.2024.03.001.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormone neuronsLung infection modelParaventricular hypothalamic nucleusSecondary to inflammationVirulent Escherichia coliSensory neuron responsesBiofilm pathogensHormone neuronsLung infectionFemale miceSensory neuronsHypothalamic nucleiInfection modelBehavioral alterationsNeuronal responsesSickness behaviorLungInflammationSigns of sicknessGram-negative bacteriaBiofilm exopolysaccharideInfectionImpact of exopolysaccharidesHypothermiaAcute stress response
2025
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Hiroki C, Hassanabad M, Defaye M, Sarden N, Bartlett A, Farias R, Nguyen A, Guerrero-Fonseca I, Yoon G, Brown L, Ma C, Yang H, Belke D, Fatehi Hassanabad A, McCoy C, Rosin N, Orton D, Fedak P, Vallance B, Yu H, Jacobson K, Khan N, Altier C, Kelly M, Yipp B. Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis. Immunity 2025, 58: 2054-2068.e6. PMID: 40449484, DOI: 10.1016/j.immuni.2025.05.002.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNeutrophil extracellular trapsPulmonary fibrosisNeutrophil recruitmentGenetic deletionVasoactive intestinal peptide administrationFibrotic lung diseaseNeutrophil-mediated inflammationRegulation of inflammationNociceptor neuronsPathological tissue repairProgression of fibrotic lung diseasePharmacological ablationMurine modelHematopoietic cellsLung diseaseNociceptorsIntestinal peptideExtracellular trapsFibrosisAlveolar macrophagesImmune processesNervous systemTissue repairSiglec-F
2023
Neutrophil swarming: Is a good offense the best defense?
Brown L, Yipp B. Neutrophil swarming: Is a good offense the best defense? IScience 2023, 26: 107655. PMID: 37670784, PMCID: PMC10475518, DOI: 10.1016/j.isci.2023.107655.Peer-Reviewed Original Research
2022
Inflammatory platelet death drives sepsis
Brown L, Yipp B. Inflammatory platelet death drives sepsis. Nature Cardiovascular Research 2022, 1: 689-690. PMID: 35975232, PMCID: PMC9372963, DOI: 10.1038/s44161-022-00111-y.Peer-Reviewed Original ResearchSurfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut
Varon J, Arciniegas Rubio A, Amador-Munoz D, Corcoran A, DeCorte J, Isabelle C, Pinilla Vera M, Walker K, Brown L, Cernadas M, Bry L, Yang H, Kitsios G, McVerry B, Morris A, Lee H, Howrylak J, Englert J, Baron R. Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut. Critical Care Explorations 2022, 4: e0699. PMID: 35620769, PMCID: PMC9119639, DOI: 10.1097/cce.0000000000000699.Peer-Reviewed Original ResearchSurfactant protein DHeterozygous parentsEscherichia coli colonizationAbdominal sepsisCecal ligationAcademic medical centerProtein DGut colonizationProtein expressionMiceMedical CenterWestern blottingMouse gutBacteremiaCLPGreen fluorescent proteinSepsisMortalityCecal floraColonGutGut segmentsFluorescent proteinCecal contentsGallbladder
2021
Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli
Boucher E, Brown L, Lahiri P, Cobo E. Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli. Cell And Tissue Research 2021, 383: 1203-1208. PMID: 33496883, DOI: 10.1007/s00441-020-03362-y.Peer-Reviewed Original ResearchConceptsEndogenous functionsFunctions of cathelicidinsCathelicidin-deficient micePhagocytic cell lineFunction of phagocytic cellsEscherichia coliExogenous cathelicidinCationic peptidesHuman cathelicidinMurine cathelicidinLL-37CathelicidinImpaired phagocytosisCell linesPhagocytic cellsPeritoneal macrophagesMacrophagesPhagocytosisProtective effectMicePeritonitis
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