John D MacMicking, PhD

Associate Professor of Microbial Pathogenesis and of Immunobiology; Member, Yale Systems Biology Institute; Investigator, Howard Hughes Medical Institute

Contact Information

John D MacMicking, PhD

Mailing Address

  • Howard Hughes Medical Institute, Yale Systems Biology Institute, 850 West Campus Drive, ISTC 341

    West Haven, CT, 06516-7389

    United States

John D MacMicking
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Appointments

Biography

John MacMicking is a Howard Hughes Medical Institute (HHMI) Investigator. He trained in synthetic organic chemistry at the Australian National University (B.Sc, 1st Class Honors) where he conducted thesis work in the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the the John Curtin School of Medical Research.

He then came to the U.S. to pursue Ph.D studies with Carl Nathan in the Immunology program at Cornell University-Sloan-Kettering Institute in New York City before being selected as an HHMI Life Science Research Foundation Fellow at The Rockefeller University to conduct studies with John Mckinney.

His doctoral dissertation described the first knockout of an innate immune gene in mammals - inducible nitric oxide synthase (iNOS) - genetically engineered between 1992-1995. It served as an early paradigm for cell-autonomous immunity to infection. At Rockefeller University he computationally identified, physically mapped and began functionally characterizing a complete IFN-inducible GTPase superfamily in humans and mice as a new defense network operating against all pathogen classes. For these discoveries he has been named a Edward Mallinckrodt Jr Foundation Fellow (2004), Searle Scholar (2005), Cancer Research Institute Investigator (2006), Burroughs-Wellcome Fund Investigator (2008), CCFA Senior Research Awardee (2010), AAF Scholar (2014) and Kenneth Rainin Foundation Innovator (2014).

Dr. MacMicking was promoted to Associate Professor in 2010 and received Tenure in 2014. He was chosen as an HHMI Investigator in 2015 before moving to the Yale Systems Biology Institute in 2017. 

Education & Training

  • PhD
    Cornell University (1997)
  • BS
    Australian National Univ (1990)
  • Assistant Professor (Adjunct)
    The Rockefeller University
  • Research Associate
    The Rockefeller University
  • HHMI LSRF Fellow
    The Rockefeller University
  • Revson Biomedical Fellow
    The Rockefeller University

Activities

  • German Research Foundation (DFG)

    Bonn, Germany 2013
    International Reviewer, Life Sciences 2 Programme
  • French National Research Agency (ANR)
    Paris, France 2012
    International Reviewer, Programme Blanc International
  • Health Research Board of Ireland (HRB)
    Dublin, Ireland 2011
    International Reviewer, Translational Medicine Fellowships Programme
  • European Research Council (ERC)
    Brussels, Belgium 2011
    International Reviewer, European Union 7th Research Framework Advanced Grants Programme (FP7)
  • Medical Research Council (MRC)
    London, United Kingdom 2009
    International Reviewer, Strategic Grants Programme

Honors & Recognition

AwardAwarding OrganizationDate
Howard Hughes Medical Institute (HHMI) Investigator2015
Innovator Award, Kenneth Rainin Foundation2014
American Asthma Foundation (AAF) Scholar2014
Crohn’s and Colitis Foundation of America (CCFA) Senior Investigator Award2010
Burroughs Wellcome Fund (BWF) Investigator in the Pathogenesis of Infectious Disease Award2008
Cancer Research Institute (CRI) Investigator Award2006
Searle Scholar2005
Edward Mallinckrodt, Jr. Foundation Fellow2004
HHMI Life Science Research Foundation (LSRF) Fellow The Rockefeller University1998
Charles H. Revson Fellow in Biomedical ResearchThe Rockefeller University1997
Distinguished Student Commencement Speaker AwardCornell University-Sloan-Kettering Institute, New York, NY1997

Professional Service

OrganizationRoleDate
Cellular MicrobiologyEditorial Board2017 - Present
American Society of MicrobiologyPresident and President-Elect, Immunology Division2014 - 2016
NIAID, NIHStanding member, Immunity and Host Defense (IHD) Study Section2013 - 2015

Departments & Organizations