Kallol Gupta, PhD

Trained as a chemist, I was introduced to the world of biology through the aquatic route, where my goal was to uncover the molecular diversity present in the venoms of marine cone snails and understand how it impairs the functions of key ion channels and transporters. This introduced me to the world of membrane proteins and fascinated me.

I subsequently moved to the University of Oxford as a Fellow of the 1851 Royal Commission. My research led to a transformative advancement that enabled top-down mass spectrometric (MS) analysis of membrane protein-lipid complexes. The application of this approach yielded an atomistic understanding of how lipids act as key signaling molecules that regulate the structural and functional organization of membrane proteins.

In the Fall of 2018, I crossed the pond to start my own lab at Yale. Combining native mass spectrometry with an array of orthogonal chemical biology and experimental and computational approaches, our lab is focused on developing platforms that enable quantitative analysis of macromolecular protein complexes directly from the cellular environment. Applying this, the lab aims to understand how the spatiotemporal organization of membrane proteins and lipids regulates cellular physiology. For more, check out https://www.theguptalab.com/