Ilan Harpaz-Rotem, PhD, ABPP
Glenn H. Greenberg Professor of Psychiatry and of PsychologyDownloadHi-Res Photo
Cards
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
About
Copy Link
Titles
Glenn H. Greenberg Professor of Psychiatry and of Psychology
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Positions outside Yale
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Biography
Dr. Harpaz-Rotem is a Professor of Psychiatry and of Psychology at Yale University. He is a clinical psychologist who, for many years, has conducted research and provided treatment to individuals exposed to trauma. Dr. Harpaz-Rotem serves as an investigator at the National Center for PTSD, and he also directs the evaluation of VA PTSD treatment programs at the Department of Veterans Affairs, Northeast Program Evaluation Center, Office of Mental Health and Suicide Prevention, VA Central Office. Research into how to modify traumatic memories and their associated emotions is one of the core questions that guide his work.
Last Updated on December 15, 2022.
Appointments
Psychiatry
ProfessorPrimaryDepartment of Psychology
ProfessorSecondary
Other Departments & Organizations
- All Institutions
- Center for Brain & Mind Health
- Department of Psychology
- Harpaz-Rotem Lab
- MR Core
- Psychiatry
- Psychology Section
- VA National Center for PTSD
- VA-Yale Clinical Neurosciences PTSD Research Program
- Wu Tsai Institute
- Yale Ventures
Education & Training
- Postdoc
- NIH NRSA Postdoctoral Fellowship Yale University Department of Psychiatry (2004)
- PhD
- New School for Social Research (2002)
- Clinical training
- University of California at Davis School of Medicine (2002)
- Clinical training
- Albert Einstein School of Medicine Bronx Lebanon Hospital (2001)
- Clinical training
- New York University Medical Center & Bellevue Hospital (2000)
- Clinical training
- Beth Israel Medical Center (1998)
Research
Copy Link
Overview
Medical Research Interests
Afghanistan; Anxiety Disorders; Biomarkers, Pharmacological; Depression; Iraq; Magnetic Resonance Imaging; Mental Health Services; Positron Emission Tomography Computed Tomography; Psychiatry; Psychotherapy; Stress Disorders, Post-Traumatic; Veterans
ORCID
0000-0002-6066-9406- View Lab Website
Harpaz-Rotem PTSD Treatment & Research Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ilan Harpaz-Rotem's published research.
Publications Timeline
A big-picture view of Ilan Harpaz-Rotem's research output by year.
Research Interests
Research topics Ilan Harpaz-Rotem is interested in exploring.
Jack Tsai
Or Duek, PhD
John Krystal, MD
Tobias Spiller, MD
Ifat Levy, PhD
Robert Pietrzak, PhD, MPH
202Publications
5,972Citations
Stress Disorders, Post-Traumatic
Veterans
Magnetic Resonance Imaging
Psychotherapy
Mental Health Services
Depression
Publications
2026
Associations Between Mental Health Conditions and Adverse Pregnancy Outcomes Among Active‐Duty Servicewomen
Manzo L, Hall C, Combellick J, Harpaz‐Rotem I, Phillips A, Burrell M, Kiang C, Womack J. Associations Between Mental Health Conditions and Adverse Pregnancy Outcomes Among Active‐Duty Servicewomen. Paediatric And Perinatal Epidemiology 2026 PMID: 41878886, DOI: 10.1111/ppe.70139.Peer-Reviewed Original ResearchConceptsMental health conditionsMental health diagnosesAdverse pregnancy outcomesHealth conditionsActive-duty servicewomenAssociation of mental health diagnosesHealth diagnosisPregnancy outcomesRisk ratioConfidence intervalsPoisson regression modelsRisk of preterm birthLive-birth pregnanciesMilitary populationDemographic characteristicsActive-dutyCivilian womenGestational diabetesPregnancy complicationsRegression modelsPreterm birthHigh riskComorbid diagnosesOutcomesRiskRelationship between rumination and symptoms of posttraumatic stress disorder – a cross-sectional network analysis
Zhabenko O, Ben-Zion Z, Raffelhüschen P, Burrer A, Seifritz E, Just S, Preller K, Duek O, Paterson M, Pietrzak R, Joormann J, Spiller T, Harpaz-Rotem I. Relationship between rumination and symptoms of posttraumatic stress disorder – a cross-sectional network analysis. Frontiers In Psychiatry 2026, 17: 1786768. DOI: 10.3389/fpsyt.2026.1786768.Peer-Reviewed Original ResearchConceptsSymptoms of posttraumatic stress disorderItem levelPosttraumatic Stress Disorder ChecklistAdult survivorsSurvivors of traumatic eventsCross-sectional network analysisMaintenance of PTSDGeneralized anxiety disorderRepetitive Thinking QuestionnairePosttraumatic stress disorderSymptoms of PTSDPatient Health QuestionnaireRisk-taking behaviorRTQ-10Hyperarousal clustersIntrusive memoriesAnxiety disordersPTSD symptomsRepetitive thoughtsPCL-5Stress disorderMood clusterCognitive processesGAD-7Thinking QuestionnaireNeural Correlates of Social Cognitive Functioning in Borderline Personality Disorder and Posttraumatic Stress Disorder: A Scoping Review
Samonek K, Basol E, Estrada S, Davydovska T, Funaro M, Harpaz-Rotem I. Neural Correlates of Social Cognitive Functioning in Borderline Personality Disorder and Posttraumatic Stress Disorder: A Scoping Review. Chronic Stress 2026, 10 DOI: 10.1177/24705470261427216.Peer-Reviewed Original ResearchConceptsBorderline personality disorderPosttraumatic stress disorderNeurobiology of social cognitionSocial cognitive functioningSocial cognitionTheory of mindPersonality disorderStress disorderNeural correlatesCo-occurrence of borderline personality disorderCognitive functionSocial perceptionThreat-relevant cuesComorbid samplePrefrontal hypoactivationComorbid presentationsEmotional processingFMRI findingsNeurobiological mechanismsBehavioral abnormalitiesTemporoparietal regionPosterior temporalCognitionDisordersNeurobiologyChildhood Maltreatment and Deviations from Normative Brain Structure: A Mega-Analysis of 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD Working Groups
Wang H, Liu Z, Pozzi E, Hussain A, Sigar P, Abdallah C, Alexander N, Baker J, Bauer J, Blackford J, Cisler J, Connolly C, Cotton A, Daniels J, Dannlowski U, Densmore M, deRoon-Cassini T, Dima D, Du Plessis S, Etkin A, Fani N, Fisch L, Fitzgerald J, Frodl T, Fu C, Gonul A, Gordon E, Gotlib I, Goya-Maldonado R, Groenewold N, Grotegerd D, Hahn T, Hamilton J, Han L, Harpaz-Rotem I, Haswell C, Herringa R, Herzog J, Ipser J, Jahanshad N, Jovanovic T, Kaufman M, Kircher T, Konowski M, Koopowitz S, Krug A, Krystal J, Lanius R, Larson C, Lazarov A, Lebois L, Leehr E, Levy I, Li M, Manthey A, Maron-Katz A, McIntosh A, McLaughlin K, Meinert S, Mwangi B, Nelson S, Nenadić I, Neria Y, Neufeld R, Ojha A, Olatunji B, Olson E, Opel N, Peverill M, Ressler K, Ross M, Rosso I, Sacchet M, Sambrook K, Schmahl C, Seedat S, Shenton M, Sicorello M, Sierk A, Soares J, Stein D, Stein F, Stein M, Suarez-Jimenez B, Théberge J, Thomopoulos S, Tomas C, Usemann P, van den Heuvel L, van Rooij S, Walter H, Walter M, Wang X, Whalley H, Winter N, Wu M, Xie H, Yang T, Zhu X, Zilcha-Mano S, Zunta-Soares G, Frangou S, Thompson P, Salminen L, Sun D, Morey R, Stevens J, Schmaal L, Ho T. Childhood Maltreatment and Deviations from Normative Brain Structure: A Mega-Analysis of 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD Working Groups. Biological Psychiatry 2026 PMID: 41791639, DOI: 10.1016/j.biopsych.2026.02.016.Peer-Reviewed Original ResearchAltmetricConceptsMajor depressive disorderPosttraumatic stress disorderChildhood maltreatmentSubcortical volumesCortical thicknessWhole-brain MRI dataMedial orbitofrontal cortexMiddle frontal regionsAssociated with large volumesOrbitofrontal cortexDepressive disorderTransdiagnostic effectsStress disorderNeuroanatomical alterationsBrain morphometryPutamen volumeIsthmus cingulateParietal regionsBrain structuresFrontal regionsOccipital cortexMega-AnalysisEntorhinal cortexAdverse experiencesAssociated with elevated riskThreading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale
Cheng A, Konova A, Powers A, Corlett P, Levy I, Gu X, Huys Q, Pushkarskya H, Fineberg S, Hauser T, Bzdok D, Harpaz-Rotem I, Babuscio T, Nichols L, Zhao Y, Sharma M, Meeker D, Xu H, Rutledge R, Pearlson G, Pittenger C, Yip S. Threading the needle: Practical considerations for merging theory-driven computational psychiatry with data-driven analytics to enhance precision health at scale. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41763489, DOI: 10.1016/j.bpsc.2026.02.009.Peer-Reviewed Original ResearchConceptsComputational psychiatryLongitudinal trajectoriesLongitudinal dataParsing heterogeneityDiagnostic boundariesBehavioral tasksPsychiatric disordersPsychiatric diagnosticsDimensional approachLongitudinal courseSymptom trajectoriesCognitive processesDiagnostic categoriesPsychiatryIndividual changesUnderlying mechanismsClinical research methodsClinical researchHiTOPRDoCIndividualsClinical realityDisordersSymptomsTaskPerinatal mental health conditions among U.S. active component service women, 2016-2022.
Manzo L, Hall C, Harpaz-Rotem I, Phillips A, Womack J, Combellick J. Perinatal mental health conditions among U.S. active component service women, 2016-2022. MSMR Medical Surveillance Monthly Report 2026, 32: 36-43. PMID: 41687061, PMCID: PMC12965757.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsActive duty service womenMental health conditionsPerinatal mental health conditionsPrevalence of mental health conditionsHealth conditionsYear postpartumService womenInternational ClassificationYear prior to pregnancyNon-Hispanic blacksClinical Modification diagnosis codesInternational Classification of DiseasesStressor-related disordersClassification of diseasesSuicidal ideationDepressive disorderMaternal mortalityLive-born deliveriesDiagnosis codesPostpartum periodActive component service womenPregnancy startPanic disorderPostpartumMilitary rankFinding Common Ground on Conceptualization and Treatment: Reply to , , , and
Rubenstein A, Doran J, Duek O, Harpaz-Rotem I. Finding Common Ground on Conceptualization and Treatment: Reply to , , , and. American Psychologist 2026, 81: 121-122. PMID: 41609609, DOI: 10.1037/amp0001638.Peer-Reviewed Original ResearchTracking facial emotion expressions during prolonged exposure therapy in a ketamine-enhanced PTSD treatment trial
Davydovska T, Abrgiel M, Harpaz-Rotem I. Tracking facial emotion expressions during prolonged exposure therapy in a ketamine-enhanced PTSD treatment trial. Neuroscience Applied 2026, 5: 106615. DOI: 10.1016/j.nsa.2025.106615.Peer-Reviewed Original Research
2025
The exposure continuum model: A theoretical framework for understanding exposure across trauma-centered psychotherapies
Rubinstein D, Korem N, Bullard D, Harpaz-Rotem I. The exposure continuum model: A theoretical framework for understanding exposure across trauma-centered psychotherapies. Journal Of Anxiety Disorders 2025, 117: 103107. PMID: 41371190, DOI: 10.1016/j.janxdis.2025.103107.Peer-Reviewed Original ResearchConceptsTrauma-focused therapyExposure therapyNeurobiological mechanismsTrauma typesIndividual differencesSymptom severityTrauma treatmentExposure componentPsychotherapyTherapeutic settingData-driven explorationTreatment approachesExposure techniqueTherapistsTraumaSymptomsTheoretical frameworkExposureTheoretical paperTherapeutic approachesCliniciansTherapySeverityTreatmentDimensionsDissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures
Ben-Zion Z, Basol E, Simon A, Abargil M, Samonek K, Paterson M, Spiller T, Duek O, Just S, Preller K, Keynan J, Admon R, Liberzon I, Shalev A, Hendler T, Levy I, Joormann J, Scheinost D, Harpaz-Rotem I. Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures. Biological Psychiatry 2025 PMID: 41319905, PMCID: PMC12784315, DOI: 10.1016/j.biopsych.2025.11.016.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPosttraumatic stress disorderConnectome-based predictive modelingEmotional painSymptom networksNeural signaturesSymptom severityStudy 1PTSD dimensionsPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder symptomsSubjective ratingsTrauma-exposed individualsTrauma-related psychopathologyDiverse symptom presentationsPost-traumaRatings of fearMechanism-based interventionsCentral executiveEmotional reactivityDSM-5PCL-5Distressing memoriesStress disorderDefault-modeCentral symptoms
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
IRB ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsUsing Neuroimaging to track symptom change in PTSD treatment
IRB ID2000025892RolePrincipal InvestigatorPrimary Completion Date07/31/2029Recruiting ParticipantsImaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
IRB ID1005006735RoleSub InvestigatorPrimary Completion Date12/31/2016Recruiting ParticipantsGenderMaleAge18 years - 55 yearsImaging mGluR5 and synaptic density in psychiatric disorders
IRB ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 yearsIntensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy (PTSD)
IRB ID1509016530RolePrincipal InvestigatorPrimary Completion Date08/01/2030Recruiting ParticipantsGenderBothAge21 years - 70 years
Academic Achievements & Community Involvement
Copy Link
Honors
honor Distinguished Mentorship Award
11/11/2022National AwardInternational Society for Traumatic Stress Studies (ISTSS)DetailsUnited States
News & Links
Copy Link
News
- January 13, 2026
More Than Just Fear: A New Profile of Post-traumatic Stress Disorder
- October 20, 2025
Understanding PTSD and Dissociation in Wartime: Direct and Indirect Trauma Exposure
- September 18, 2025
Yale Scientists Seek to Uncover Neural and Genomic Mechanisms that Drive Anxiety
- March 10, 2025Source: Yale News
Machine Learning Model Predicts PTSD Symptom Severity Over Time
Get In Touch
Copy Link
Contacts
Academic Office Number
Mailing Address
Psychiatry
300 George Street
New Haven, CT 06511
United States
Locations
300 George Street
Academic Office
Rm 836
New Haven, CT 06511