Heping Zhang, PhD
Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive SciencesCards
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
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Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
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About
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Titles
Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive Sciences
Affiliated Faculty, Yale Institute for Global Health
Biography
Dr. Zhang published over 420 research articles and monographs in theory and applications of statistical methods and in several areas of biomedical research including epidemiology, genetics, child and women health, mental health, substance use, and reproductive medicine. He directed a training program in mental health research that was funded by the NIMH. He directs the Collaborative Center for Statistics in Science that coordinates the Reproductive Medicine Network to evaluate treatment effectiveness for infertility. He is a fellow of the American Statistical Association and a fellow of the Institute of Mathematical Statistics. He was named the 2008 Myrto Lefokopoulou distinguished lecturer by Harvard School of Public Health and a Medallion Award and Lecturer by the Institute of Mathematical Statistics. In 2011, he received the Royan International Award on Reproductive Health. Dr. Zhang was the president of the International Chinese Statistical Association in 2019. He is a former-editor of the Journal of the American Statistical Association - Applications and Case Studies. He was the recipient of the 2022 Neyman Award and Lecture by the Institute of Mathematical Statistics and the 2023 Distinguished Achievement Award by the International Chinese Statistical Association. He was selected as a 2023 Highly Cited Researcher in cross field by Web of Science. He received the Samuel S. Wilks Award by the American Statistical Association in 2026.
Appointments
Biostatistics
ProfessorPrimaryChild Study Center
ProfessorSecondaryStatistics
ProfessorSecondary
Other Departments & Organizations
- Big Data Summer Immersion at Yale
- Biostatistics
- Center for Brain & Mind Health
- Child Study Center
- Collaborative Center for Statistics in Science (C2S2)
- Computational Biology and Biomedical Informatics
- Global Health Studies
- High Performance Computation
- Public Health Data Science and Data Equity
- Statistics
- Stress & Addiction Clinical Research Program
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Institute for Global Health
- Yale School of Public Health
- Yale Ventures
- YSPH Global Health Concentration
Education & Training
- PhD
- Stanford University (1991)
Research
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Overview
- Analysis of Genomic Data for Complex Traits
- Data Coordination Center for Reproductive Medicine
- Clinical Trials for Infertility Treatments
Medical Research Interests
Public Health Interests
ORCIDs
- View Lab Website
Collaborative Center for Statistics in Science
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Joel Gelernter, MD
Hao Huang, MD, MPH
Xingguang Luo, MD
James Leckman, MD, PhD
Fangbai (Janet) Sun, MPH
Hugh Taylor, MD
Pregnancy
Infertility
Computational Biology
Genomics
Publications
2026
On the d-blocker number of k-ary n-cubes
Wu H, Zhang H. On the d-blocker number of k-ary n-cubes. Applied Mathematics And Computation 2026, 531: 130219. DOI: 10.1016/j.amc.2026.130219.Peer-Reviewed Original ResearchKappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [11C]EKAP PET imaging
Weiss E, Bartlett E, Naganawa M, Asch R, Hart-Derrick V, Miller R, Freeman D, Duraney E, Nabulsi N, Radhakrishnan R, Matuskey D, Huang Y, Enferadi M, Zhang H, Davis M. Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [11C]EKAP PET imaging. Biological Psychiatry 2026, s0006-3223(26)01356-9. PMID: 42373036, PMCID: PMC13626198, DOI: 10.1016/j.biopsych.2026.06.017.Peer-Reviewed Original ResearchAltmetricGenetically Informed Brain Parcellation Through Structured Multi-Task Modeling
Yao Y, Hu Y, Wang S, Dai W, Liu Z, Zhang H. Genetically Informed Brain Parcellation Through Structured Multi-Task Modeling. Journal Of The American Statistical Association 2026, ahead-of-print: 1-14. DOI: 10.1080/01621459.2026.2657607.Peer-Reviewed Original ResearchCCR2 Enhances Anti-Intracellular Bacterial Infection by Modulating Macrophage Pyroptosis to Rebalance Th Immune Responses
Yang S, Yu J, Zeng J, Sun R, Tuo Y, Tan L, Zhang H, Li J, Che X, Bai H. CCR2 Enhances Anti-Intracellular Bacterial Infection by Modulating Macrophage Pyroptosis to Rebalance Th Immune Responses. Microorganisms 2026, 14: 1339. PMID: 42354963, PMCID: PMC13306128, DOI: 10.3390/microorganisms14061339.Peer-Reviewed Original ResearchStructure-aware retinal disentanglement reveals the genetic architecture of ocular and systemic diseases
Wei C, Zhang H, Huang R, Cai Z, Wu H, Zhong C, Zhang J, Yang X, Sun L, Wang X, Chen Z, Wu H, Liu Y, Tan H. Structure-aware retinal disentanglement reveals the genetic architecture of ocular and systemic diseases. PLOS Digital Health 2026, 5: e0001376. PMID: 42139265, PMCID: PMC13178874, DOI: 10.1371/journal.pdig.0001376.Peer-Reviewed Original ResearchAltmetricPromoting APC function of B cells via reprogramming the fatty acid metabolism enhances anticancer immunity in metastatic ovarian cancer
Zhang H, Yu C, Du W, Li H, Liu Z, Li X, Yue Y, Wang B, Wang H, Ouyang Y, Wu H, Feng X, Yu J, Liu Y, Ji B, Cai S, Zhang H, Deng W. Promoting APC function of B cells via reprogramming the fatty acid metabolism enhances anticancer immunity in metastatic ovarian cancer. Cancer Immunology, Immunotherapy 2026, 75: 145. PMID: 41984099, PMCID: PMC13083572, DOI: 10.1007/s00262-026-04387-y.Peer-Reviewed Original ResearchHDAC6 Promotes Host Defense Against Chlamydial Lung Infections by Regulating M2-Th2 Responses
Yu J, Yang S, Zha X, Tuo Y, Sun R, Zhang H, Tan L, Bai H. HDAC6 Promotes Host Defense Against Chlamydial Lung Infections by Regulating M2-Th2 Responses. International Journal Of Molecular Sciences 2026, 27: 3009. PMID: 41977198, PMCID: PMC13073687, DOI: 10.3390/ijms27073009.Peer-Reviewed Original ResearchBall Impurity: Measuring Heterogeneity in General Metric Spaces
Che M, Li T, Pan W, Wang X, Zhang H. Ball Impurity: Measuring Heterogeneity in General Metric Spaces. Journal Of The American Statistical Association 2026, ahead-of-print: 1-13. DOI: 10.1080/01621459.2025.2595733.Peer-Reviewed Original ResearchArginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth
Zhao W, Wang G, Wang P, Ma B, Liu B, Fu Y, Tang Y, Duan X, Zhou K, Zhang J, Zhu W, Zhang H, Yu Y. Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth. Oncogene 2026, 45: 1220-1233. PMID: 41795022, DOI: 10.1038/s41388-026-03712-0.Peer-Reviewed Original ResearchCitationsAltmetricRegionalization of China’s PM2.5: A robust functional spatial clustering with angular depth
Wang T, Wang X, Guo X, Zhang H. Regionalization of China’s PM2.5: A robust functional spatial clustering with angular depth. The Annals Of Applied Statistics 2026, 20: 197-214. DOI: 10.1214/26-aoas2141.Peer-Reviewed Original ResearchCitations
Clinical Trials
Current Trials
FRIEND study- Fibroids and Unexplained Infertility Treatment with Epigallocatechin Gallate; A Natural CompounD in Green Tea
IRB ID2000032871RolePrincipal InvestigatorPrimary Completion Date05/31/2025Recruiting ParticipantsGenderFemaleAge18 years - 40 years
Academic Achievements & Community Involvement
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Activities
activity Connecticut Academy of Science and Engineering
07/01/2025 - PresentProfessional OrganizationsCouncil Memberactivity Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome (FreFro-PCOS)
01/01/2012 - 01/01/2014ResearchDetailsJinan, Shandong Sheng, ChinaAbstract/SynopsisFrom http://Clinicaltrials.gov: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age. However, the optimal infertility treatment for PCOS patients is still a matter of controversy. Despite producing more follicles and more oocytes than other women undergoing controlled ovarian hyperstimulation during an IVF cycle, women with PCOS have comparable or lower pregnancy rates. Additionally women with PCOS patients undergoing IVF have a higher risk of developing ovarian hyperstimulation syndrome (OHSS), which may be aggravated by pregnancy after an embryo transfer in a fresh cycle. Further women with PCOS are thought to have higher rates of later pregnancy complications including spontaneous abortion, pre-eclampsia, and preterm labor that may be related to impaired implantation in the superovulated endometrium. We propose a randomized clinical trial of elective embryo cryopreservation followed by a programmed cycle of endometrial preparation and frozen embryo transfer (FET) compared to fresh embryo transfer in women with PCOS undergoing in vitro fertilization (IVF).
Honors
honor Samuel S. Wilks Memorial Award
08/04/2026International AwardAmerican Statistical AssociationDetailsUnited Stateshonor Highly Cited Researcher in Cross Field
11/15/2023International AwardWeb of Sciencehonor Distinguished Achievement Award
08/09/2023International AwardInternational Chinese Statistical Associationhonor Neyman Award and Lecture
06/29/2022International AwardInstitute of Mathematical StatisticsDetailsUnited Stateshonor Royan International Research Award
09/08/2011International AwardRoyan InstituteDetailsUnited States
News
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News
- July 23, 2025
Digging into data science at the 38th Annual New England Statistical Symposium
- September 30, 2024
Pepper Center Awards Drive Aging and Dementia Studies
- August 17, 2023
Biostatistics leaders honored by ICSA
- November 28, 2022
Yale Biostatistician Heping Zhang Delivers Prestigious Neyman Lecture
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300 George Street
Academic Office
Ste 523
New Haven, CT 06511