Xingguang Luo, MD
Associate Research Scientist in PsychiatryCards
Appointments
Psychiatry
Primary
Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Titles
Assistant Professor, Psychiatry
Contact Info
About
Titles
Associate Research Scientist in Psychiatry
Assistant Professor, PsychiatryAppointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Assistant Professor (2006-2012)
- Yale University School of Medicine (2012)
- Post-doc (2000-2003)
- Yale University (2003)
- MD
- Shanghai Medical University (2000)
Research
Overview
NIH R01: Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
NIH R21: Deep sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
NIH R21: Post-GWAS transcriptome-wide LncRNA profiling in alcoholism
Medical Subject Headings (MeSH)
Behavior and Behavior Mechanisms; Mental Disorders; Psychiatry and Psychology
ORCID
0000-0003-3585-042X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingguang Luo's published research.
Publications Timeline
A big-picture view of Xingguang Luo's research output by year.
Research Interests
Research topics Xingguang Luo is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Joel Gelernter, MD
John Krystal, MD
Heping Zhang, PhD
Lingeng Lu, MD, PhD
Bao-Zhu Yang, PhD
175Publications
4,070Citations
Mental Disorders
Publications
2024
Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesPhenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder
Guo X, Luo X, Zhang Y, Yu Z, Tan Z, Cao L, Ji J, Wang X, Wang K, Wang Z, Li C, Tan Y, Luo X. Phenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder. Asian Journal Of Psychiatry 2024, 98: 104145. PMID: 38959548, DOI: 10.1016/j.ajp.2024.104145.Peer-Reviewed Original ResearchSerum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchAltmetricConceptsYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathwayCorrelation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor typeDoes Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?
Jiao Q, Dong Y, Ma X, Ji S, Liu X, Zhang J, Sun X, Li D, Luo X, Zhang Y. Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatric Disease And Treatment 2024, 20: 353-361. PMID: 38415074, PMCID: PMC10898600, DOI: 10.2147/ndt.s453447.Peer-Reviewed Original ResearchConceptsHDRS-17 total scoreFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMajor depressive disorderHDRS-17FED patientsCPT-IPCognitive functionBaseline cognitive functionTotal scoreDepressive disorderFirst-episodeDrug-naivePatients' responses to antidepressant treatmentFunctioning Assessment Short Test total scoreResponse to antidepressant treatmentHamilton Depression Rating ScaleFunctioning Assessment Short Test scoreConsensus Cognitive BatteryDepression Rating ScaleAssociated with worse cognitive functionSpeed of processingHamilton Anxiety ScaleDrug-naive patientsInterpersonal relationship domain
2023
Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Yang K, Du R, Yang Q, Zhao R, Fan F, Chen S, Luo X, Tan S, Wang Z, Yu T, Tian B, Le T, Li C, Tan Y. Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence. Brain Imaging And Behavior 2023, 18: 331-342. PMID: 38078981, DOI: 10.1007/s11682-023-00838-7.Peer-Reviewed Original ResearchRNA m6A methylation in psychiatric disorders.
Mao Q, Luo J, Luo X, Zhu X, Wang K, Zuo L, Zhang Y, Luo X. RNA m6A methylation in psychiatric disorders. EC Psychology And Psychiatry 2023, 12 PMID: 38145106, PMCID: PMC10745284.Peer-Reviewed Original ResearchConceptsMajor psychiatric disordersPsychiatric disordersM6A modificationM6A methyltransferase METTL3Synaptic protein synthesisInflammatory infiltrationImmune infiltrationRNA m6A methylationTherapeutic targetM6A regulatorsAlzheimer's diseaseNeuropsychiatric disordersMethyltransferase METTL3Subtype classificationPromising targetDiseaseDisordersM6A methylationInfiltrationCritical roleProtein synthesisReviewPathogenesisComprehensive reviewPreventionCorrelation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchCitationsConceptsImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivityRegional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrusImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanism
Academic Achievements and Community Involvement
activity Reviewer
Peer Review Groups and Grant Study SectionsDetailsDescription1. Archive of General Psychiatry (2007-) 2. Molecular Psychiatry (2007-) 3. Biological Psychiatry (2006-) 4. Pharmacogenetics and Genomics (2006-) 5. Neuropsychopharmacology (2007-) 6. Drug and Alcohol Dependence (2006-) 7. American Journal of Medical Genetics B (2007-) 8. Psychiatric Genetics (2005-) 9. Neuroscience Letters (2005-) 10. Methods and Findings (2006-) 11. Alcohol Research & Health (2006-) 12. Alcoholism: Clinical and Experimental Research (2007-) 13. Genes, Brain and Behavior (2007-) 14. Schizophrenia research (2008-) 15. Psychopharmacology (2008-) 16. Alcohol - An International Biomedical Journal (2008-) 17. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2008-) 18. Journal of Personality 19. BMC Psychiatry (2009-) 20. Addiction Biology (2010-) 21. Diabetes Research and Clinical Practice (2010-) 22. PLoS One (2011-) 23. The International Journal of Neuropsychopharmacology (2011-) 24. Journal of Clinical Psychiatry (2012-) 25. Human Psychopharmacology: Clinical and Experimental (2012-)
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