Hao Xu
Postgraduate Associate in ImmunobiologyAbout
Research
Publications
2025
METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell
Ding C, Yang X, Liu H, Roulis M, Chen H, Chen Y, Xu H, Gao Y, Zhong J, Li H, Ye Y, Cai W, Hu W, Wang Z. METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell. Journal Of Molecular Cell Biology 2025, 17: mjae060. PMID: 39762134, PMCID: PMC12309382, DOI: 10.1093/jmcb/mjae060.Peer-Reviewed Original ResearchSelf-RenewalStem cellsMaturation of goblet cellsDifferentiation of Lgr5Ulcerative colitisHomeostasis of intestinal epitheliumColonic stem cellsGoblet cellsSpontaneous inflammationIntestinal dysplasiaColonic mucosaUC treatmentLgr5Epithelium integrityDepletion of METTL3Intestinal epitheliumTherapeutic targetInflammationDifferentiation capacityMETTL3 expressionUC samplesMETTL3 levelsExpression levelsM6A methylationCells
2022
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. RNA m6A demethylase ALKBH5 regulates the development of γδ T cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2203318119. PMID: 35939687, PMCID: PMC9388086, DOI: 10.1073/pnas.2203318119.Peer-Reviewed Original ResearchConceptsDemethylase ALKBH5Messenger RNAΓδ T cellsΓδ T cell biologyCommon posttranscriptional modificationΓδ T cell developmentT cell biologyT cell developmentCell precursorsT cell precursorsMammalian cellsRNA modificationsPosttranscriptional modificationsTissue homeostasisCell biologyT cellsTarget genesCheckpoint roleCell developmentM6A demethylase ALKBH5ALKBH5Γδ T-cell originΓδ T cell repertoireCell populationsEarly developmentm6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway
Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB. m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway. Science Advances 2022, 8: eabl5723. PMID: 35333576, PMCID: PMC8956260, DOI: 10.1126/sciadv.abl5723.Peer-Reviewed Original ResearchConceptsMucosal barrier dysfunctionInflammatory bowel diseaseBarrier dysfunctionColonic epithelial cellsColonic mucosal barrier dysfunctionEpithelial cellsStem cellsNF-κB pathwayPotential therapeutic targetEpithelial cell deathEpithelial cell homeostasisSevere colitisBowel diseaseColonic stem cellsTherapeutic targetMouse colonStem cell apoptosisDysfunctionMajor causeCell apoptosisImportant modulatorPathological processesAntiapoptotic pathwaysSpecific deletionCell homeostasis
2021
m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
Zhou J, Zhang X, Hu J, Qu R, Yu Z, Xu H, Chen H, Yan L, Ding C, Zou Q, Ye Y, Wang Z, Flavell RA, Li HB. m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity. Science Advances 2021, 7: eabg0470. PMID: 34134995, PMCID: PMC8208713, DOI: 10.1126/sciadv.abg0470.Peer-Reviewed Original ResearchAlkB homolog 5T cell-specific ablationT cellsMRNA stabilityCell-specific ablationMethyladenosine (m6 A) modificationHomolog 5Pathogenicity of CD4Messenger RNAErasersProtein expressionAdoptive transfer colitisExperimental autoimmune encephalomyelitisHomeostasis of CD4T cell responsesSpecific roleT cell pathogenicityCentral nervous system