Edward Schrom, PhD
Associate Research ScientistDownloadHi-Res Photo
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I invent mathematical algorithms, build statistical models, and write robust software to maximize insights from data.
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Associate Research Scientist
Biography
Professionally, I am a data scientist in the most precise sense: I build quantitative algorithms, models, and inference tools with the utmost rigor and care to extract real understanding from data. My primary academic focus is the emergence of individual-scale immune functioning and its population-scale consequences from the dynamic interactions of cells and molecules. This broad theme has informed a variety of my study areas, including evolutionary processes, spatial tumor architecture, and vaccination response, as I have advanced from a Ph.D. student at Princeton University to a post-doctoral researcher at the NIH to a data scientist at the CDC to an Associate Research Scientist here at the Yale School of Medicine. Personally, my passions range more broadly, including my Christian faith, my family and community, the great outdoors, all things athletic, and much more.
Last Updated on December 02, 2025.
Appointments
Immunobiology
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Special Volunteer
- National Institute of Allergy and Infectious Disease (2025)
- Post-Doctoral Fellow
- National Institute of Allergy and Infectious Disease (2024)
- PhD
- Princeton University, Ecology and Evolutionary Biology (2020)
- MA
- Princeton University, Ecology and Evolutionary Biology (2017)
- BA
- University of Virginia, Mathematics (2015)
- BS
- University of Virginia, Biology (2015)
Research
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My recent work in immunobiology addresses immunological responses to vaccination, spatial architecture of solid tumors, and dynamic lymphocyte signaling circuits. My interests and past work vary more broadly, from clinical trial design to wildlife conservation genomics to cybersecurity.
Overview
Medical Research Interests
Computational Biology; Data Analysis; Immunoinformatics; Information Theory; Nonlinear Dynamics; Systems Biology
Public Health Interests
Statistical Computing; Vaccines; Evolution; Immunology; Infectious Diseases; Modeling; Cancer; Bayesian Statistics; Bioinformatics
ORCID
0000-0002-1793-6433
Research at a Glance
Publications Timeline
A big-picture view of Edward Schrom's research output by year.
16Publications
163Citations
Publications
2025
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML
Gui G, Bingham M, Herzog J, Wong-Rolle A, Dillon L, Goswami M, Martin E, Reeves J, Kim S, Bahrami A, Degenhardt H, Zaki G, Divakar P, Schrom E, Calvo K, Hourigan C, Hansen K, Zhao C. Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML. Science Advances 2025, 11: eadw4871. PMID: 40632867, PMCID: PMC12239967, DOI: 10.1126/sciadv.adw4871.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute myeloid leukemiaAllogeneic hematopoietic stem cell transplantationGraft-versus-leukemia effectRelapsed acute myeloid leukemiaHematopoietic stem cell transplantationStem cell transplantationTumor microenvironment analysisImmune cell enrichmentLigand-receptor analysisClinical responseImmunotherapy treatmentCell transplantationNontransplant settingMyeloid leukemiaImmune cellsNiche remodelingMicroenvironment analysisImmune interactionsTherapeutic strategiesCell enrichmentLeukemiaLeukemia cellsImmunotherapySpatial transcriptomicsSingle-cell spatial transcriptomicsThe IBEX Knowledge-Base: A central resource for multiplexed imaging techniques
Radtke A, Anidi I, Arakkal L, Arroyo-Mejias A, Beuschel R, Börner K, Chu C, Clark B, Clatworthy M, Colautti J, Coscia F, Croteau J, Denha S, Dever R, Dutra W, Fritzsche S, Fullam S, Gerner M, Gola A, Gollob K, Hernandez J, Hor J, Ichise H, Jing Z, Jonigk D, Kandov E, Kastenmüller W, Koenig J, Kortekaas R, Kothurkar A, Kreins A, Lamborn I, Lin Y, Morais K, Lunich A, Luz J, MacDonald R, Makranz C, Maltez V, McDonough J, Moriarty R, Ocampo-Godinez J, Olyntho V, Oxenius A, Padhan K, Remmert K, Richoz N, Schrom E, Shang W, Shi L, Shih R, Speranza E, Stierli S, Teichmann S, Veres T, Vierhout M, Wachter B, Wade-Vallance A, Williams M, Zangger N, Germain R, Yaniv Z. The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques. PLOS Biology 2025, 23: e3003070. PMID: 40106489, PMCID: PMC12135934, DOI: 10.1371/journal.pbio.3003070.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsSpatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels
Schrom E, McCaffrey E, Sreejithkumar V, Radtke A, Ichise H, Arroyo-Mejias A, Speranza E, Arakkal L, Thakur N, Grant S, Germain R. Spatial Patterning Analysis of Cellular Ensembles (SPACE) finds complex spatial organization at the cell and tissue levels. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412146122. PMID: 39903116, PMCID: PMC11831171, DOI: 10.1073/pnas.2412146122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSpatial patterns of cellsPatterns of co-occurrenceSpatial pattern analysisInformation theoretic frameworkComplex spatial organizationPatterns of cellsTranscriptomic methodsSingle imageRandom assortmentR packageCellular ensemblesSpatial patternsTissue organizationQuantitative gradientPattern ensemblesSpatial organization
2024
550 PD-1-mediated inhibition is critical to the development and maintenance of high affinity stem-like CD8+ T cells in the tumor draining lymph node
Hor J, Schrom E, Wong-Rolle A, Vistain L, Shang W, Dong Q, Zhao C, Jin C, Germain R. 550 PD-1-mediated inhibition is critical to the development and maintenance of high affinity stem-like CD8+ T cells in the tumor draining lymph node. 2024, a624-a624. DOI: 10.1136/jitc-2024-sitc2024.0550.Peer-Reviewed Original Research3D extension of spatial patterning analysis of cellular ensembles (SPACE) to extract parameters for dynamic tumor modeling
Sreejithkumar V, Schrom E, Germain R. 3D extension of spatial patterning analysis of cellular ensembles (SPACE) to extract parameters for dynamic tumor modeling. The Journal Of Immunology 2024, 212: 0245_4416-0245_4416. DOI: 10.4049/jimmunol.212.supp.0245.4416.Peer-Reviewed Original ResearchPD-1/cDC1 axis in the tumor draining lymph node regulates stem-like CD8+ T cell differentiation
Hor J, Schrom E, Germain R. PD-1/cDC1 axis in the tumor draining lymph node regulates stem-like CD8+ T cell differentiation. The Journal Of Immunology 2024, 212: 1456_5371-1456_5371. DOI: 10.4049/jimmunol.212.supp.1456.5371.Peer-Reviewed Original ResearchConceptsCD8+ T cellsTumor-draining LNStem-like CD8+ T cellsT cellsPD-1Stem-like cellsCheckpoint therapyActivated CD8+ T cellsCD8+ T cell subsetsPD-1/PD-L1 signalingStem-like T cellsXCR1+ dendritic cellsCD8+ T cell differentiationTumor-draining lymph nodesPD-1 expressionIn vivo blockadeT cell expansionT cell subsetsDraining Lymph NodesT cell differentiationIntramural Research ProgramDraining LNTumor regressionEffector differentiationDendritic cells
2023
579-D Multiplex imaging of ovarian carcinoma reveals spatial cell interaction patterns predictive of immunotherapy responses
Padhan K, Lee J, Giudice E, Schrom E, Radtke A, Gupta N, An D, Huang T, Germain R. 579-D Multiplex imaging of ovarian carcinoma reveals spatial cell interaction patterns predictive of immunotherapy responses. 2023, a1805-a1805. DOI: 10.1136/jitc-2023-sitc2023.0579-d.Peer-Reviewed Original ResearchTCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways
Chan W, Cao Y, Zhao X, Schrom E, Jia D, Song J, Sibener L, Dong S, Fernandes R, Bradfield C, Smelkinson M, Kabat J, Hor J, Altan-Bonnet G, Garcia K, Germain R. TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. Journal Of Experimental Medicine 2023, 220: e20231242. PMID: 37796477, PMCID: PMC10555889, DOI: 10.1084/jem.20231242.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPD-1-mediated inhibitionPD-1 inhibitionSignaling pathwayCheckpoint blockadeCheckpoint therapyPD-1PD-L1Diverse signaling pathwaysCD80 expressionInhibitory receptorsPresenting cellsT cellsCancer therapyTCR ligandsTCRSite(s)Inhibitory effectTherapySuppressive effectPotencyInhibitionLigand qualityPathwayCD80CD28Challenges in cybersecurity: Lessons from biological defense systems
Schrom E, Kinzig A, Forrest S, Graham A, Levin S, Bergstrom C, Castillo-Chavez C, Collins J, de Boer R, Doupé A, Ensafi R, Feldman S, Grenfell B, Halderman J, Huijben S, Maley C, Moses M, Perelson A, Perrings C, Plotkin J, Rexford J, Tiwari M. Challenges in cybersecurity: Lessons from biological defense systems. Mathematical Biosciences 2023, 362: 109024. PMID: 37270102, DOI: 10.1016/j.mbs.2023.109024.Peer-Reviewed Original ResearchCitationsAltmetric
2022
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells
Johansen K, Golec D, Huang B, Park C, Thomsen J, Preite S, Cannons J, Garçon F, Schrom E, Courrèges C, Veres T, Harrison J, Nus M, Phelan J, Bergmeier W, Kehrl J, Okkenhaug K, Schwartzberg P. A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells. Science Signaling 2022, 15: eabl9169. PMID: 35857633, PMCID: PMC9637254, DOI: 10.1126/scisignal.abl9169.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, CDCell AdhesionCell Adhesion MoleculesClustered Regularly Interspaced Short Palindromic RepeatsGTPase-Activating ProteinsIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1MicePhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesT-LymphocytesConceptsLFA-1 activationPI3KNegative regulatorProduct phosphatidylinositol 3,4,5-trisphosphateLFA-1-mediated adhesionIntegrin lymphocyte function-associated antigen-1Binding of LFA-1 to ICAM-1Inside-out signalingPhosphatidylinositol 3,4,5-trisphosphateT cell receptorPI3K effectorsPrimary mouse T cellsPhosphoinositide 3-kinaseLFA-1CRISPR screensT cellsRap1 activationGuide RNAsMultiple proteinsICAM-1RASA3Mouse T cellsT cell migrationRap1PI3
Academic Achievements & Community Involvement
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activity Spatial Patterning Analysis of Cell Ensembles: Discovering Spatial Relationships among Cell Types in Tissues
09/10/2024 - 09/12/2024Oral PresentationStanford Spatial Biology SummitDetailsPresented remotely.Collaboratorsactivity Spatial Patterning Analysis of Cell Ensembles: A General Framework for Characterizing Spatial Relationships Among Cell Types in Tissues
06/05/2023 - 06/05/2023LectureNorthwestern University Feinberg School of Medicine Division of Pulmonary and Critical Care Medicine Research-in-Progress SeminarDetailsPresented remotely.activity Spatial Patterning Analysis of Cell Ensembles: A General Framework for Characterizing Spatial Relationships Among Cell Types in Tissue
04/18/2023 - 04/21/2023Poster PresentationCold Spring Harbor Labs Meeting on Systems ImmunologyDetailsCold Spring Harbor, NY, United StatesCollaboratorsactivity Nautilus
2023 - 2023Media PresenceAuthoractivity Workshop Participant
06/08/2022 - 06/10/2022OtherDistributed Computing Perspectives on Theoretical ImmunologyDetailsSanta Fe, NM, United States
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